Embleya_NPDC021375 - 56 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NPDC021375.ctg-0001 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene-precursor	246,593	267,684

NPDC021375.ctg-0003 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	T1PKS	17,138	158,792	Medium	ionostatin	PKS
Region 3.2	lanthipeptide-class-i	678,119	703,328

NPDC021375.ctg-0005 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 5.1	atropopeptide	165,415	186,458
Region 5.2	hydrogen-cyanide	239,345	252,084	Low	aborycin	ribosomal:RiPP
Region 5.3	T3PKS	367,693	408,748	High	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone/2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	PKS:Type III
Region 5.4	NRP-metallophore,NRPS	453,871	523,881	High	griseobactin	NRPS:Type I

NPDC021375.ctg-0006 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	RiPP-like	2,875	13,687
Region 6.2	terpene,betalactone	124,160	165,668	Low	hopene	terpene
Region 6.3	terpene	223,146	244,210
Region 6.4	T1PKS	415,207	488,020	Low	Neoabyssomicin B/Abyssomicin 2/Abyssomicin 4	PKS

NPDC021375.ctg-0007 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 7.1	NRPS-like,T1PKS	40,880	89,183
Region 7.2	NRPS,T1PKS	115,892	165,254	Medium	pactamide A/pactamide B/pactamide C/pactamide D/pactamide E/pactamide F	NRPS:Type I+PKS
Region 7.3	NI-siderophore,lanthipeptide-class-ii	251,541	291,051
Region 7.4	terpene,NRP-metallophore,NRPS	316,882	396,677	Low	madurastatin A2/madurastatin E1/madurastatin F/madurastatin G1/madurastatin A1	NRPS:Type I
Region 7.5	CDPS	429,047	449,823

NPDC021375.ctg-0008 (Embleya spp)

Region	Type	From	To
Region 8.1	terpene	13,767	36,510
Region 8.2	terpene	232,992	255,307
Region 8.3	HR-T2PKS,phosphonate	422,336	464,735

NPDC021375.ctg-0009 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 9.1	NAPAA,T1PKS,hglE-KS	1	64,379
Region 9.2	lanthipeptide-class-iv	122,907	145,870
Region 9.3	NI-siderophore	173,928	207,678	Low	schizokinen	NRPS:Type IV
Region 9.4	NI-siderophore	328,616	358,529

NPDC021375.ctg-0010 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	NI-siderophore	27,940	59,455	Low	peucechelin	NRPS:Type I
Region 10.2	NRPS,lanthipeptide-class-ii	60,391	115,972
Region 10.3	lanthipeptide-class-i	147,264	171,836
Region 10.4	NRPS	195,172	248,821
Region 10.5	terpene	390,115	405,638

NPDC021375.ctg-0011 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 11.1	T3PKS	15,915	57,024
Region 11.2	lanthipeptide-class-iii	107,438	130,035	High	SapB	ribosomal:RiPP:Lanthipeptide
Region 11.3	NRPS-like,NRPS	182,272	249,526	Medium	himastatin	NRPS:Type I
Region 11.4	NRPS	300,072	350,561

NPDC021375.ctg-0013 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 13.1	NRPS	92,405	146,085	Low	didemnin B/nordidemnin B/dehydrodidemnin B (aplidine)/didemnin X/didemnin Y	NRPS:Type I+PKS
Region 13.2	NRPS,NRPS-like	275,695	337,741	Low	vioprolide A/vioprolide B/vioprolide C/vioprolide D	NRPS:Type I

NPDC021375.ctg-0014 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 14.1	RiPP-like	50,958	63,243
Region 14.2	NRPS-like,benzoxazole,T1PKS	67,524	191,943	High	caboxamycin	other:shikimate-derived
Region 14.3	terpene	211,454	233,437

NPDC021375.ctg-0015 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 15.1	ectoine	21,894	32,292	High	ectoine	other:ectoine
Region 15.2	hglE-KS,NAPAA	58,971	133,750	Low	γ-poly-L-2,4-diaminobutyric acid	NRPS:Type I
Region 15.3	lassopeptide	146,394	168,923	Low	humidimycin	ribosomal:RiPP
Region 15.4	atropopeptide	181,907	202,989

NPDC021375.ctg-0018 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 18.1	NRPS-like,NRPS	106,366	160,418
Region 18.2	RRE-containing	207,048	223,023

NPDC021375.ctg-0019 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 19.1	NRPS-like	57,886	100,570
Region 19.2	terpene,NRPS,T1PKS	112,551	204,956	High	polyoxypeptin	NRPS:Type I+PKS

NPDC021375.ctg-0021 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 21.1	T1PKS	49,186	121,097	Medium	borrelidin	PKS
Region 21.2	azole-containing-RiPP	131,929	160,498

NPDC021375.ctg-0022 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 22.1	lanthipeptide-class-ii	56,826	84,841	Medium	birimositide	ribosomal:RiPP:Lanthipeptide

NPDC021375.ctg-0023 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 23.1	terpene-precursor	39,343	60,365

NPDC021375.ctg-0024 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 24.1	lanthipeptide-class-iv	55,245	91,318
Region 24.2	hydrogen-cyanide	117,556	130,696

NPDC021375.ctg-0026 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 26.1	T2PKS	1	72,478	High	spore pigment	PKS

NPDC021375.ctg-0027 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 27.1	NRPS	83,286	106,810	Low	depsibosamycin B/depsibosamycin C/depsibosamycin D	NRPS:Type I

NPDC021375.ctg-0029 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 29.1	butyrolactone	51,903	62,862

NPDC021375.ctg-0039 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 39.1	NRPS-like	8,819	33,430	Low	echinomycin	NRPS:Type I

NPDC021375.ctg-0043 (Embleya spp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 43.1	hglE-KS	1	21,849

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene-precursor	246,593	267,684
Region 3.1	T1PKS	17,138	158,792	Medium	ionostatin	PKS
Region 3.2	lanthipeptide-class-i	678,119	703,328
Region 5.1	atropopeptide	165,415	186,458
Region 5.2	hydrogen-cyanide	239,345	252,084	Low	aborycin	ribosomal:RiPP
Region 5.3	T3PKS	367,693	408,748	High	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone/2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	PKS:Type III
Region 5.4	NRP-metallophore,NRPS	453,871	523,881	High	griseobactin	NRPS:Type I
Region 6.1	RiPP-like	2,875	13,687
Region 6.2	terpene,betalactone	124,160	165,668	Low	hopene	terpene
Region 6.3	terpene	223,146	244,210
Region 6.4	T1PKS	415,207	488,020	Low	Neoabyssomicin B/Abyssomicin 2/Abyssomicin 4	PKS
Region 7.1	NRPS-like,T1PKS	40,880	89,183
Region 7.2	NRPS,T1PKS	115,892	165,254	Medium	pactamide A/pactamide B/pactamide C/pactamide D/pactamide E/pactamide F	NRPS:Type I+PKS
Region 7.3	NI-siderophore,lanthipeptide-class-ii	251,541	291,051
Region 7.4	terpene,NRP-metallophore,NRPS	316,882	396,677	Low	madurastatin A2/madurastatin E1/madurastatin F/madurastatin G1/madurastatin A1	NRPS:Type I
Region 7.5	CDPS	429,047	449,823
Region 8.1	terpene	13,767	36,510
Region 8.2	terpene	232,992	255,307
Region 8.3	HR-T2PKS,phosphonate	422,336	464,735
Region 9.1	NAPAA,T1PKS,hglE-KS	1	64,379
Region 9.2	lanthipeptide-class-iv	122,907	145,870
Region 9.3	NI-siderophore	173,928	207,678	Low	schizokinen	NRPS:Type IV
Region 9.4	NI-siderophore	328,616	358,529
Region 10.1	NI-siderophore	27,940	59,455	Low	peucechelin	NRPS:Type I
Region 10.2	NRPS,lanthipeptide-class-ii	60,391	115,972
Region 10.3	lanthipeptide-class-i	147,264	171,836
Region 10.4	NRPS	195,172	248,821
Region 10.5	terpene	390,115	405,638
Region 11.1	T3PKS	15,915	57,024
Region 11.2	lanthipeptide-class-iii	107,438	130,035	High	SapB	ribosomal:RiPP:Lanthipeptide
Region 11.3	NRPS-like,NRPS	182,272	249,526	Medium	himastatin	NRPS:Type I
Region 11.4	NRPS	300,072	350,561
Region 13.1	NRPS	92,405	146,085	Low	didemnin B/nordidemnin B/dehydrodidemnin B (aplidine)/didemnin X/didemnin Y	NRPS:Type I+PKS
Region 13.2	NRPS,NRPS-like	275,695	337,741	Low	vioprolide A/vioprolide B/vioprolide C/vioprolide D	NRPS:Type I
Region 14.1	RiPP-like	50,958	63,243
Region 14.2	NRPS-like,benzoxazole,T1PKS	67,524	191,943	High	caboxamycin	other:shikimate-derived
Region 14.3	terpene	211,454	233,437
Region 15.1	ectoine	21,894	32,292	High	ectoine	other:ectoine
Region 15.2	hglE-KS,NAPAA	58,971	133,750	Low	γ-poly-L-2,4-diaminobutyric acid	NRPS:Type I
Region 15.3	lassopeptide	146,394	168,923	Low	humidimycin	ribosomal:RiPP
Region 15.4	atropopeptide	181,907	202,989
Region 18.1	NRPS-like,NRPS	106,366	160,418
Region 18.2	RRE-containing	207,048	223,023
Region 19.1	NRPS-like	57,886	100,570
Region 19.2	terpene,NRPS,T1PKS	112,551	204,956	High	polyoxypeptin	NRPS:Type I+PKS
Region 21.1	T1PKS	49,186	121,097	Medium	borrelidin	PKS
Region 21.2	azole-containing-RiPP	131,929	160,498
Region 22.1	lanthipeptide-class-ii	56,826	84,841	Medium	birimositide	ribosomal:RiPP:Lanthipeptide
Region 23.1	terpene-precursor	39,343	60,365
Region 24.1	lanthipeptide-class-iv	55,245	91,318
Region 24.2	hydrogen-cyanide	117,556	130,696
Region 26.1	T2PKS	1	72,478	High	spore pigment	PKS
Region 27.1	NRPS	83,286	106,810	Low	depsibosamycin B/depsibosamycin C/depsibosamycin D	NRPS:Type I
Region 29.1	butyrolactone	51,903	62,862
Region 39.1	NRPS-like	8,819	33,430	Low	echinomycin	NRPS:Type I
Region 43.1	hglE-KS	1	21,849

No secondary metabolite regions were found in these records:: NPDC021375.ctg-0002 (Embleya spp); NPDC021375.ctg-0004 (Embleya spp); NPDC021375.ctg-0012 (Embleya spp); NPDC021375.ctg-0016 (Embleya spp); NPDC021375.ctg-0017 (Embleya spp); NPDC021375.ctg-0020 (Embleya spp); NPDC021375.ctg-0025 (Embleya spp); NPDC021375.ctg-0028 (Embleya spp); NPDC021375.ctg-0030 (Embleya spp); NPDC021375.ctg-0031 (Embleya spp); NPDC021375.ctg-0032 (Embleya spp); NPDC021375.ctg-0033 (Embleya spp); NPDC021375.ctg-0034 (Embleya spp); NPDC021375.ctg-0035 (Embleya spp); NPDC021375.ctg-0036 (Embleya spp); NPDC021375.ctg-0037 (Embleya spp); NPDC021375.ctg-0038 (Embleya spp); NPDC021375.ctg-0040 (Embleya spp); NPDC021375.ctg-0041 (Embleya spp); NPDC021375.ctg-0042 (Embleya spp); NPDC021375.ctg-0044 (Embleya spp); NPDC021375.ctg-0045 (Embleya spp); NPDC021375.ctg-0046 (Embleya spp); NPDC021375.ctg-0047 (Embleya spp); NPDC021375.ctg-0048 (Embleya spp); NPDC021375.ctg-0049 (Embleya spp); NPDC021375.ctg-0050 (Embleya spp); NPDC021375.ctg-0051 (Embleya spp); NPDC021375.ctg-0052 (Embleya spp); NPDC021375.ctg-0053 (Embleya spp); NPDC021375.ctg-0054 (Embleya spp); NPDC021375.ctg-0055 (Embleya spp); NPDC021375.ctg-0056 (Embleya spp); NPDC021375.ctg-0057 (Embleya spp); NPDC021375.ctg-0058 (Embleya spp); NPDC021375.ctg-0059 (Embleya spp); NPDC021375.ctg-0060 (Embleya spp); NPDC021375.ctg-0061 (Embleya spp); NPDC021375.ctg-0062 (Embleya spp); NPDC021375.ctg-0063 (Embleya spp); NPDC021375.ctg-0064 (Embleya spp); NPDC021375.ctg-0065 (Embleya spp)

Compact view

NPDC021375.ctg-0001 - Region 1 - terpene-precursor

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Location: 246,593 - 267,684 nt. (total: 21,092 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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Gene overview

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ClusterBlast

KnownClusterBlast

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Terpene

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

CDS_00231: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

CDS_00238: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

CDS_00239: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

Transferases: phosphorylase

CDS_00236: thiamine-phosphate pyrophosphorylase

smcogs: SMCOG1280: thiamine-phosphate pyrophosphorylase

Ligases: synthetase

CDS_00234: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000677.5	0.43	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001456.3	0.41	terpene	isorenieratene	Streptomyces argillaceus
BGC0000664.5	0.41	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000648.3	0.41	terpene	carotenoid	Myxococcus xanthus
BGC0000649.3	0.40	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000633.3	0.40	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.40	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0002345.2	0.40	other (other)	hydrogen cyanide	Pseudomonas fluorescens
BGC0001910.4	0.40	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000678.5	0.39	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000677.5	0.43	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001456.3	0.41	terpene	isorenieratene	Streptomyces argillaceus
BGC0000664.5	0.41	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000648.3	0.41	terpene	carotenoid	Myxococcus xanthus
BGC0000649.3	0.40	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000633.3	0.40	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.40	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0002345.2	0.40	other (other)	hydrogen cyanide	Pseudomonas fluorescens
BGC0001910.4	0.40	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000678.5	0.39	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

CDS_00234: PT_FPPS_like

Domain 1 (46 - 361): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.94 out of 24.78

Confidence: strong

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 24.24 out of 29.65

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.84 out of 36.53

Confidence: medium

Additional weak hits (5):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.47 out of 20.97

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.50 out of 21.55

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.18 out of 26.33

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.13 out of 28.19

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.02 out of 23.43

Confidence: weak

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
DmdR1	Iron(II)-dependent repressor
LexA variant 1	Repressor of DNA damage response
LexA variant 2	Repressor of DNA damage response

NPDC021375.ctg-0003 - Region 1 - T1PKS

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Location: 17,138 - 158,792 nt. (total: 141,655 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

CDS_01565: monooxygenase FAD-binding

smcogs: SMCOG1246: monooxygenase FAD-binding

CDS_01569: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CDS_01574: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: acylase

CDS_01571: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Ligases: synthase

CDS_01566: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

CDS_01567: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

CDS_01568: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

CDS_01572: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	0.74	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.74	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.73	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.73	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000067.5	0.67	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000041.3	0.65	PKS	oronofacic acid	Pseudomonas syringae
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000166.5	0.62	PKS	tylactone	Streptomyces fradiae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	0.74	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.74	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.73	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.73	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000067.5	0.67	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000041.3	0.65	PKS	oronofacic acid	Pseudomonas syringae
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000166.5	0.62	PKS	tylactone	Streptomyces fradiae

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 21.84 out of 21.84

Confidence: strong

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 30.20 out of 30.98

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.80 out of 20.47

Confidence: medium

Additional weak hits (10):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.11 out of 32.74

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 17.99 out of 26.33

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.48 out of 19.26

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.87 out of 30.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.43 out of 32.74

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.99 out of 30.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.50 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.04 out of 26.06

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.83 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.73 out of 28.19

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 17137 - 158792:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ccmal - redmal - Me-ccmal - Me-redmal - Me-ccmal - redmal) + (ohmal - Me-ohmal) + (Me-ccmal) + (pk - ohmal - Me-mal) + (redmal) + (Me-ccmal - ohmal) + (Me-ohmal - Me-redmal)
Non-colinear ordering:: CDS_01572 + CDS_01571 + CDS_01563 + CDS_01569 + CDS_01568 + CDS_01567 + CDS_01566

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_01563: mmal

PKS_AT (580..875): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.1
Ethylmalonyl-CoA: 175.5
Methoxymalonyl-CoA: 150.2
2-Methylbutyryl-CoA: 122.3
trans-1,2-CPDA: 108.6
Propionyl-CoA: 106.2
Malonyl-CoA: 101.0
CHC-CoA: 83.4
Isobutyryl-CoA: 57.7
Benzoyl-CoA: 47.5
inactive: 33.8
3-Methylbutyryl-CoA: 29.2
fatty_acid: 27.3
Acetyl-CoA: 21.5

CDS_01566: mmal - mmal

PKS_AT (574..869): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 215.2
Ethylmalonyl-CoA: 206.9
Methoxymalonyl-CoA: 176.3
2-Methylbutyryl-CoA: 147.2
trans-1,2-CPDA: 138.7
Propionyl-CoA: 103.8
CHC-CoA: 98.9
Malonyl-CoA: 93.1
Isobutyryl-CoA: 70.3
Benzoyl-CoA: 60.0
3-Methylbutyryl-CoA: 40.9
Acetyl-CoA: 33.9
inactive: 26.3
fatty_acid: 22.1

PKS_AT (2144..2443): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 213.6
Ethylmalonyl-CoA: 210.4
Methoxymalonyl-CoA: 179.6
2-Methylbutyryl-CoA: 155.5
trans-1,2-CPDA: 129.8
Propionyl-CoA: 107.8
Malonyl-CoA: 104.9
CHC-CoA: 98.1
Isobutyryl-CoA: 73.1
Benzoyl-CoA: 56.6
fatty_acid: 50.0
Acetyl-CoA: 41.4
3-Methylbutyryl-CoA: 36.0
inactive: 35.9

CDS_01567: mmal - mal

PKS_AT (574..870): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.3
Ethylmalonyl-CoA: 197.4
Methoxymalonyl-CoA: 159.2
trans-1,2-CPDA: 126.9
2-Methylbutyryl-CoA: 112.7
Propionyl-CoA: 102.7
CHC-CoA: 89.4
Malonyl-CoA: 88.4
Benzoyl-CoA: 51.8
Isobutyryl-CoA: 44.7
fatty_acid: 25.0
Acetyl-CoA: 22.1
inactive: 21.6
3-Methylbutyryl-CoA: 5.5

PKS_AT (2333..2635): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 220.4
inactive: 95.5
Methoxymalonyl-CoA: 71.7
Methylmalonyl-CoA: 63.4
Propionyl-CoA: 37.3
Isobutyryl-CoA: 33.3
Benzoyl-CoA: 26.7
Ethylmalonyl-CoA: 23.7
Acetyl-CoA: 23.0
trans-1,2-CPDA: 13.7
2-Methylbutyryl-CoA: 10.1
CHC-CoA: 7.8
fatty_acid: 7.4
3-Methylbutyryl-CoA: 0.0

CDS_01568: mal

PKS_AT (576..883): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.7
inactive: 98.2
Methoxymalonyl-CoA: 49.7
Methylmalonyl-CoA: 43.3
Propionyl-CoA: 41.4
Acetyl-CoA: 11.0
Isobutyryl-CoA: 8.2
CHC-CoA: 5.6
Ethylmalonyl-CoA: 1.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

CDS_01569: pk - mal - mmal

PKS_AT (576..872): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 215.3
Methylmalonyl-CoA: 214.3
Methoxymalonyl-CoA: 169.4
trans-1,2-CPDA: 139.6
2-Methylbutyryl-CoA: 131.5
Propionyl-CoA: 106.3
CHC-CoA: 93.7
Malonyl-CoA: 80.9
Benzoyl-CoA: 64.1
Isobutyryl-CoA: 62.2
3-Methylbutyryl-CoA: 42.0
Acetyl-CoA: 39.0
fatty_acid: 36.4
inactive: 22.2

PKS_AT (2648..2947): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 214.9
inactive: 97.3
Methylmalonyl-CoA: 58.3
Methoxymalonyl-CoA: 55.3
Propionyl-CoA: 32.3
Isobutyryl-CoA: 23.5
Acetyl-CoA: 19.8
Ethylmalonyl-CoA: 19.5
CHC-CoA: 13.9
Benzoyl-CoA: 11.8
fatty_acid: 8.5
2-Methylbutyryl-CoA: 8.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4250..4546): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 213.6
Ethylmalonyl-CoA: 211.8
Methoxymalonyl-CoA: 177.5
2-Methylbutyryl-CoA: 151.6
trans-1,2-CPDA: 140.0
Propionyl-CoA: 121.7
CHC-CoA: 117.7
Malonyl-CoA: 99.9
Isobutyryl-CoA: 73.2
Benzoyl-CoA: 57.1
Acetyl-CoA: 47.7
fatty_acid: 40.3
3-Methylbutyryl-CoA: 37.5
inactive: 17.8

CDS_01571: mal - mmal

PKS_AT (584..885): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 202.4
inactive: 82.9
Methoxymalonyl-CoA: 60.6
Methylmalonyl-CoA: 51.1
Propionyl-CoA: 31.5
Isobutyryl-CoA: 29.5
Benzoyl-CoA: 19.7
Acetyl-CoA: 19.4
Ethylmalonyl-CoA: 16.3
2-Methylbutyryl-CoA: 14.2
trans-1,2-CPDA: 9.6
CHC-CoA: 2.4
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2084..2376): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.3
Ethylmalonyl-CoA: 184.1
Methoxymalonyl-CoA: 158.2
2-Methylbutyryl-CoA: 143.1
trans-1,2-CPDA: 122.8
Propionyl-CoA: 112.8
CHC-CoA: 110.6
Malonyl-CoA: 103.2
Isobutyryl-CoA: 80.1
Benzoyl-CoA: 51.0
Acetyl-CoA: 34.4
fatty_acid: 32.8
inactive: 31.7
3-Methylbutyryl-CoA: 31.6

CDS_01572: mmal - mmal - mal - mmal - mmal - mmal - mal

PKS_AT (547..843): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.1
Ethylmalonyl-CoA: 201.4
Methoxymalonyl-CoA: 162.4
2-Methylbutyryl-CoA: 140.4
trans-1,2-CPDA: 129.5
Propionyl-CoA: 102.3
CHC-CoA: 101.4
Malonyl-CoA: 76.8
Isobutyryl-CoA: 66.7
Benzoyl-CoA: 55.1
3-Methylbutyryl-CoA: 40.6
fatty_acid: 28.3
Acetyl-CoA: 27.2
inactive: 18.1

PKS_AT (1584..1880): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 215.1
Ethylmalonyl-CoA: 214.1
Methoxymalonyl-CoA: 171.7
trans-1,2-CPDA: 141.8
2-Methylbutyryl-CoA: 138.0
Propionyl-CoA: 112.4
CHC-CoA: 98.5
Malonyl-CoA: 84.8
Benzoyl-CoA: 64.8
Isobutyryl-CoA: 61.2
3-Methylbutyryl-CoA: 48.9
Acetyl-CoA: 41.8
fatty_acid: 39.1
inactive: 28.9

PKS_AT (3355..3647): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 217.0
inactive: 88.6
Methoxymalonyl-CoA: 59.2
Methylmalonyl-CoA: 58.4
Propionyl-CoA: 39.6
Acetyl-CoA: 22.8
Isobutyryl-CoA: 21.9
Ethylmalonyl-CoA: 19.7
Benzoyl-CoA: 12.5
CHC-CoA: 10.8
fatty_acid: 10.5
trans-1,2-CPDA: 9.5
2-Methylbutyryl-CoA: 9.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (5449..5745): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 218.8
Ethylmalonyl-CoA: 216.1
Methoxymalonyl-CoA: 174.2
trans-1,2-CPDA: 144.1
2-Methylbutyryl-CoA: 138.2
Propionyl-CoA: 112.9
CHC-CoA: 100.5
Malonyl-CoA: 90.7
Isobutyryl-CoA: 74.9
Benzoyl-CoA: 63.5
3-Methylbutyryl-CoA: 50.6
Acetyl-CoA: 40.6
fatty_acid: 36.9
inactive: 33.6

PKS_AT (7207..7503): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 220.7
Ethylmalonyl-CoA: 219.8
Methoxymalonyl-CoA: 176.6
trans-1,2-CPDA: 143.8
2-Methylbutyryl-CoA: 139.1
Propionyl-CoA: 111.7
CHC-CoA: 100.0
Malonyl-CoA: 92.9
Isobutyryl-CoA: 77.6
Benzoyl-CoA: 64.4
3-Methylbutyryl-CoA: 45.4
Acetyl-CoA: 37.0
fatty_acid: 36.4
inactive: 34.9

PKS_AT (9302..9598): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 215.8
Ethylmalonyl-CoA: 212.6
Methoxymalonyl-CoA: 172.6
trans-1,2-CPDA: 140.1
2-Methylbutyryl-CoA: 138.7
Propionyl-CoA: 110.3
CHC-CoA: 99.1
Malonyl-CoA: 86.4
Benzoyl-CoA: 61.8
Isobutyryl-CoA: 54.4
3-Methylbutyryl-CoA: 50.9
Acetyl-CoA: 41.4
fatty_acid: 34.4
inactive: 25.7

PKS_AT (11086..11394): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 196.0
inactive: 85.6
Methoxymalonyl-CoA: 51.6
Methylmalonyl-CoA: 47.2
Propionyl-CoA: 37.8
Acetyl-CoA: 25.0
Isobutyryl-CoA: 21.4
2-Methylbutyryl-CoA: 10.6
Benzoyl-CoA: 8.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -2.5

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
MexT	Global virulence regulator
NuR	Nickel-responsive regulator
VqsM	Regulator of quorum-sensing signalling systems

NPDC021375.ctg-0003 - Region 2 - lanthipeptide-class-i

Download region GenBank file

Download region SVG

Location: 678,119 - 703,328 nt. (total: 25,210 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

CDS_02088: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

CDS_02094: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Lyases: cyclase dehydratase

CDS_02084: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

CDS_02085: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002635.2	0.52	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0001289.5	0.51	ribosomal	penisin	Paenibacillus ehimensis
BGC0000506.4	0.49	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000541.5	0.49	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0002316.2	0.49	ribosomal	cebulantin	Saccharopolyspora cebuensis
BGC0000542.3	0.48	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000559.4	0.48	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000538.3	0.48	ribosomal	nisin Z	Lactococcus lactis
BGC0000543.5	0.47	ribosomal	pep5	Staphylococcus epidermidis
BGC0000556.5	0.47	ribosomal	streptin	Streptococcus pyogenes

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002635.2	0.52	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0001289.5	0.51	ribosomal	penisin	Paenibacillus ehimensis
BGC0000506.4	0.49	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000541.5	0.49	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0002316.2	0.49	ribosomal	cebulantin	Saccharopolyspora cebuensis
BGC0000542.3	0.48	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000559.4	0.48	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000538.3	0.48	ribosomal	nisin Z	Lactococcus lactis
BGC0000543.5	0.47	ribosomal	pep5	Staphylococcus epidermidis
BGC0000556.5	0.47	ribosomal	streptin	Streptococcus pyogenes

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for CDS_02085

CDS_02086

Leader:

MSARTSAPTVEPCQGDANDADDDPFQLDITIIENTPATE

Core:

TVLMCSTGDNCGSSCPSACTTS

Core with dehydrations:

DhbVLMCysDhaDhbGDNCysGDhaDhaCysPDhaACysDhbDhbDha

antiSMASH-DB 4.0 matches for CDS_02086

100.0%

NZ_CP029042.1:

Lanthipeptides: DDE74_RS17120_lanthipeptide

1

TVLMCSTGDNCGSSCPSACTTS

22

TVLMCSTGDNCGSSCPSACTTS

1

TVLMCSTGDNCGSSCPSACTTS

22

95.5%

NZ_BBYG01000011.1and 23 others:

NZ_BBZE01000004.1 Lanthipeptides: AOQ56_RS00075_lanthipeptideNZ_BMUG01000008.1 Lanthipeptides: IE264_RS24565_lanthipeptideNZ_CP013219.1 Lanthipeptides: SHL15_RS30830_lanthipeptideNZ_CP021978.1 Lanthipeptides: CEB94_RS33350_lanthipeptideNZ_CP029342.1 Lanthipeptides: B9S64_RS02555_lanthipeptideNZ_CP030073.1 Lanthipeptides: DN051_RS07240_lanthipeptideNZ_CP041610.2 Lanthipeptides: FNV62_RS40125_lanthipeptideNZ_CP041613.2 Lanthipeptides: FNV68_RS42745_lanthipeptideNZ_CP051006.1 Lanthipeptides: HEP81_RS07390_lanthipeptideNZ_CP074102.1 Lanthipeptides: SMIR_RS04425_lanthipeptideNZ_CP101397.1 Lanthipeptides: NLU04_RS20150_lanthipeptideNZ_CP113910.1 Lanthipeptides: HUV60_RS04250_lanthipeptideNZ_FKJI03000004.1 Lanthipeptides: A7P67_RS09720_lanthipeptideNZ_JACHCX010000047.1 Lanthipeptides: HDC93_RS37275_lanthipeptideNZ_KQ948477.1 Lanthipeptides: AQJ27_RS43755_lanthipeptideNZ_KQ948550.1 Lanthipeptides: AQJ30_RS07460_lanthipeptideNZ_LIVY01000006.1 Lanthipeptides: AMK30_RS21645_lanthipeptideNZ_LMDL01000002.1 Lanthipeptides: ASD08_RS03885_lanthipeptideNZ_RAII01000001.1 Lanthipeptides: EBH12_RS06225_lanthipeptideNZ_SHKS01000004.1 Lanthipeptides: EV567_RS16240_lanthipeptideNZ_SHKU01000001.1 Lanthipeptides: EV284_RS02155_lanthipeptideNZ_SZNQ01000001.1 Lanthipeptides: E4U91_RS28815_lanthipeptideNZ_VIUV01000003.1 Lanthipeptides: FB570_RS08885_lanthipeptide

Lanthipeptides: AOQ37_RS11080_lanthipeptide

1

TVLMCSTGDNCGSSCPSACTTS

22

TVLMCSTGD CGSSCPSACTTS

1

TVLMCSTGDTCGSSCPSACTTS

22

95.5%

NZ_CP045178.1:

Lanthipeptides: GBW32_RS14380_lanthipeptide

1

TVLMCSTGDNCGSSCPSACTTS

22

T+LMCSTGDNCGSSCPSACTTS

1

TMLMCSTGDNCGSSCPSACTTS

22

with 172 more sequence matches

Only the first 10 are displayed here.

95.5%

NZ_KI866523.1and 2 others:

NZ_VYTZ01000014.1 Lanthipeptides: F5972_RS30195_lanthipeptideNZ_VYTZ01000014.1 Lanthipeptides: F5972_RS30195_lanthipeptide

Lanthipeptides: MPTA5024_RS18085_lanthipeptide

1

TVLMCSTGDNCGSSCPSACTTS

22

TVL+CSTGDNCGSSCPSACTTS

1

TVLLCSTGDNCGSSCPSACTTS

22

95.5%

NZ_ML123117.1:

Lanthipeptides: EES46_RS09865_lanthipeptide

1

TVLMCSTGDNCGSSCPSACTTS

22

TVLMC TGDNCGSSCPSACTTS

1

TVLMCGTGDNCGSSCPSACTTS

22

90.9%

NZ_BMVW01000003.1and 2 others:

NZ_CP011799.1 Lanthipeptides: QR97_RS02045_lanthipeptideNZ_JAEVFI010000002.1 Lanthipeptides: JJV70_RS02680_lanthipeptide

Lanthipeptides: IE242_RS12765_lanthipeptide

1

TVLMCSTGDNCGSSCPSACTTS

22

TVLMCSTGD CGSSCPSAC TS

1

TVLMCSTGDTCGSSCPSACVTS

22

90.9%

NZ_CP036455.1:

Lanthipeptides: EKD16_RS21370_lanthipeptide

1

TVLMCSTGDNCGSSCPSACTTS

22

T L+CSTGDNCGSSCPSACTTS

1

TELLCSTGDNCGSSCPSACTTS

22

90.9%

NZ_CP050976.1:

Lanthipeptides: HEP86_RS36805_lanthipeptide

1

TVLMCSTGDNCGSSCPSACTTS

22

TVLMC+TGD CGSSCPSACTTS

1

TVLMCTTGDTCGSSCPSACTTS

22

90.9%

NZ_JAHLXF010000013.1:

Lanthipeptides: KQY13_RS21225_lanthipeptide

3

LMCSTGDNCGSSCPSACTTS

22

LMCSTGDNCGSSCPSACTTS

1

LMCSTGDNCGSSCPSACTTS

20

86.4%

NZ_BMSO01000039.1and 5 others:

NZ_BMTU01000002.1 Lanthipeptides: IE118_RS05930_lanthipeptideNZ_BMUK01000002.1 Lanthipeptides: IE276_RS05195_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS30040_lanthipeptideNZ_KB907208.1 Lanthipeptides: G339_RS0101560_lanthipeptideNZ_KB907208.1 Lanthipeptides: G339_RS0101560_lanthipeptide

Lanthipeptides: IE184_RS41715_lanthipeptide

3

LMCSTGDNCGSSCPSACTTS

22

LMCSTGD CGSSCPSACTTS

1

LMCSTGDTCGSSCPSACTTS

20

86.4%

NZ_FOQY01000053.1:

Lanthipeptides: BM085_RS43985_lanthipeptide

3

LMCSTGDNCGSSCPSACTTS

22

LMCSTGDNCG+SCPSACTTS

1

LMCSTGDNCGTSCPSACTTS

20

81.8%

NZ_CP070379.1:

Lanthipeptides: JVE63_RS10125_lanthipeptide

1

TVLMCSTGDNCGSSCPSACTTS

22

TVL C+TGD CGSSCPSAC TS

1

TVLTCTTGDTCGSSCPSACVTS

22

81.8%

NZ_FNCN01000004.1:

Lanthipeptides: BLQ73_RS05220_lanthipeptide

3

LMCSTGDNCGSSCPSACTTS

22

LMC TGD CGSSCPSACTTS

1

LMCGTGDTCGSSCPSACTTS

20

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.88 out of 20.47

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.07 out of 25.31

Confidence: medium

Additional weak hits (3):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.98 out of 29.25

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.89 out of 21.55

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.28 out of 24.78

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

CDS_02086 - Class I

Cleavage pHMM score: -2.50

RODEO score: 24

Monoisotopic mass: 1961.8 Da

Molecular weight: 1963.2 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 1981.2 Da N = 1; 1999.2 Da N = 2; 2017.2 Da N = 3; 2035.3 Da N = 4; 2053.3 Da N = 5

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 156 - 240; Score: 61.7

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
VqsM	Regulator of quorum-sensing signalling systems

NPDC021375.ctg-0005 - Region 1 - atropopeptide

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Location: 165,415 - 186,458 nt. (total: 21,044 nt) Show pHMM detection rules used

atropopeptide: atropopeptide_p450

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

Select a gene to view the details available for it

Gene overview

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KnownClusterBlast

SubClusterBlast

TFBS Finder

Pfam domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

CDS_02873: Biaryl bond formation

MITE: MITE0000172Biaryl bond formation (identity: 67.00%)
smcogs: SMCOG1034: cytochrome P450

CDS_02876: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Ligases: oxygenase

CDS_02873: Biaryl bond formation

MITE: MITE0000172Biaryl bond formation (identity: 67.00%)
smcogs: SMCOG1034: cytochrome P450

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002751.2	0.52	ribosomal	Amyxirubin B	Amycolatopsis xylanica
BGC0000888.5	0.44	other (other)	bacilysin	Bacillus sp. CS93
BGC0000244.4	0.41	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0001485.4	0.39	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0002496.3	0.38	NRPS	serratiochelin A, serratiochelin C, serratiochelin B	Serratia plymuthica
BGC0000894.4	0.37	other (other)	citrinin	Monascus aurantiacus
BGC0000867.3	0.36	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0001882.3	0.35	PKS	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255
BGC0000231.5	0.35	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000197.5	0.34	PKS, saccharide	aranciamycin	Streptomyces echinatus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002751.2	0.52	ribosomal	Amyxirubin B	Amycolatopsis xylanica
BGC0000888.5	0.44	other (other)	bacilysin	Bacillus sp. CS93
BGC0000244.4	0.41	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0001485.4	0.39	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0002496.3	0.38	NRPS	serratiochelin A, serratiochelin C, serratiochelin B	Serratia plymuthica
BGC0000894.4	0.37	other (other)	citrinin	Monascus aurantiacus
BGC0000867.3	0.36	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0001882.3	0.35	PKS	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255
BGC0000231.5	0.35	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000197.5	0.34	PKS, saccharide	aranciamycin	Streptomyces echinatus

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.80 out of 20.47

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.04 out of 23.79

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.67 out of 28.19

Confidence: medium

Additional weak hits (12):

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.80 out of 19.26

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.04 out of 27.78

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.28 out of 29.38

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.52 out of 31.73

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.53 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.91 out of 27.78

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.65 out of 20.97

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.25 out of 31.73

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 25.09 out of 35.63

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.46 out of 24.78

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.81 out of 29.65

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.10 out of 26.85

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
VqsM	Regulator of quorum-sensing signalling systems
ZuR variant 1	Zinc-responsive repressor

NPDC021375.ctg-0005 - Region 2 - hydrogen-cyanide

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Location: 239,345 - 252,084 nt. (total: 12,740 nt) Show pHMM detection rules used

hydrogen-cyanide: (Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

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ClusterBlast

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SubClusterBlast

TFBS Finder

Pfam domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase reductase

CDS_02933: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

CDS_02935: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

CDS_02938: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.52	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002285.2	0.40	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0002425.3	0.34	ribosomal	stlassin	Streptomyces sp.
BGC0001386.5	0.33	PKS	JBIR-76, JBIR-77	Streptomyces sp. RI-77
BGC0000595.3	0.32	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000252.5	0.32	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0002225.3	0.29	terpene	aculene A, aculene B, aculene C, asperaculane A, asperaculane B, aculene D	Aspergillus aculeatus ATCC 16872
BGC0000109.5	0.28	PKS	LL-F28249α	Streptomyces cyaneogriseus subsp. noncyanogenus
BGC0000051.5	0.28	PKS	ebelactone A, ebelactone B	Kitasatospora aburaviensis
BGC0000997.4	0.28	NRPS, PKS	glidobactin, glidobactin B, glidobactin C	[Polyangium] brachysporum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.52	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002285.2	0.40	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0002425.3	0.34	ribosomal	stlassin	Streptomyces sp.
BGC0001386.5	0.33	PKS	JBIR-76, JBIR-77	Streptomyces sp. RI-77
BGC0000595.3	0.32	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000252.5	0.32	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0002225.3	0.29	terpene	aculene A, aculene B, aculene C, asperaculane A, asperaculane B, aculene D	Aspergillus aculeatus ATCC 16872
BGC0000109.5	0.28	PKS	LL-F28249α	Streptomyces cyaneogriseus subsp. noncyanogenus
BGC0000051.5	0.28	PKS	ebelactone A, ebelactone B	Kitasatospora aburaviensis
BGC0000997.4	0.28	NRPS, PKS	glidobactin, glidobactin B, glidobactin C	[Polyangium] brachysporum

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.37 out of 20.47

Confidence: medium

Additional weak hits (7):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 16.72 out of 30.97

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 17.81 out of 33.14

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 16.96 out of 22.40

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.79 out of 19.52

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 16.96 out of 22.40

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.29 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.94 out of 24.78

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
VqsM	Regulator of quorum-sensing signalling systems

NPDC021375.ctg-0005 - Region 3 - T3PKS

Download region GenBank file

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Location: 367,693 - 408,748 nt. (total: 41,056 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

CDS_03046: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CDS_03047: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CDS_03048: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

CDS_03063: oxidoreductase

smcogs: SMCOG1161: oxidoreductase

Transferases: acetyltransferase aminotransferase kinase methyltransferase transferase

CDS_03050: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

CDS_03056: methyltransferase

smcogs: SMCOG1089: methyltransferase

CDS_03062: Methylation

MITE: MITE0000155Methylation (identity: 71.70%)
smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

CDS_03064: aminotransferase

smcogs: SMCOG1019: aminotransferase

CDS_03070: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

CDS_03074: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Ligases: synthase

CDS_03041: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

CDS_03061: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.75	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002276.2	0.52	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001831.3	0.50	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001077.4	0.50	PKS	6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone	Actinoplanes missouriensis 431
BGC0002458.3	0.50	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0001928.2	0.48	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002362.3	0.48	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0000849.4	0.45	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000207.5	0.45	PKS	chartreusin	Streptomyces chartreusis
BGC0001483.4	0.45	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.75	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002276.2	0.52	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001831.3	0.50	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001077.4	0.50	PKS	6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone	Actinoplanes missouriensis 431
BGC0002458.3	0.50	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0001928.2	0.48	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002362.3	0.48	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0000849.4	0.45	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000207.5	0.45	PKS	chartreusin	Streptomyces chartreusis
BGC0001483.4	0.45	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.33 out of 19.52

Confidence: strong

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.38 out of 19.26

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 25.20 out of 29.72

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.35 out of 23.79

Confidence: medium

Additional weak hits (13):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.96 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.85 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.55 out of 26.06

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.27 out of 26.85

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.67 out of 29.72

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.45 out of 20.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.57 out of 26.06

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.33 out of 30.22

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.85 out of 35.63

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.25 out of 36.53

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.38 out of 26.06

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.14 out of 35.63

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism
MexT	Global virulence regulator
NtrC	Nitrogen regulatory protein C

NPDC021375.ctg-0005 - Region 4 - NRP-metallophore,NRPS

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Location: 453,871 - 523,881 nt. (total: 70,011 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

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TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase reductase

CDS_03113: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CDS_03123: alkyl hydroperoxide reductase/ Thiol specific

smcogs: SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

CDS_03138: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase acyltransferase sulfhydrylase

CDS_03112: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

CDS_03143: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

CDS_03155: O-succinylhomoserine sulfhydrylase

smcogs: SMCOG1168: O-succinylhomoserine sulfhydrylase

Hydrolases: esterase hydrolase

CDS_03126: enterobactin/ferric enterobactin esterase

smcogs: SMCOG1098: enterobactin/ferric enterobactin esterase

CDS_03130: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

CDS_03141: isochorismatase

smcogs: SMCOG1027: isochorismatase

Isomerases: isomerase

CDS_03139: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase

CDS_03129: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CDS_03140: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease

CDS_03145: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.86	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.76	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.76	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.74	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.71	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4	0.71	NRPS	enniatin	Fusarium equiseti
BGC0002135.2	0.69	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001641.4	0.67	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000368.5	0.72	NRPS	griseobactin	Streptomyces sp. ATCC 700974
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.70	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.69	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.69	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000401.5	0.69	NRPS	paenibactin	Paenibacillus elgii B69
BGC0000343.5	0.69	NRPS	enterobactin	Pseudomonas sp. J465
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 33.07 out of 36.53

Confidence: strong

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 36.53 out of 36.53

Confidence: strong

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 29.48 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 30.02 out of 36.53

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

Additional weak hits (16):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.77 out of 23.43

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.67 out of 30.25

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.29 out of 29.65

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.38 out of 28.19

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.80 out of 24.78

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.16 out of 26.85

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.39 out of 36.53

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.86 out of 19.52

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.12 out of 36.53

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.56 out of 39.62

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.91 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.85 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.40 out of 26.06

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 35.63

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.27 out of 28.14

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 4, location 453870 - 523881:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Arg - Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_03129: Arg - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (502..904): Arg

nrpys: Arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DADDVGLVDK
Nearest Stachelhaus code(s):: Arg DADDVGLVDK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1586..1998): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNVGMVHK
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

CDS_03140: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (39..444): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: PLPGLGVVNK
Nearest Stachelhaus code(s):: diOH-Bz PLPGLGVVNK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
DmdR1	Iron(II)-dependent repressor

NPDC021375.ctg-0006 - Region 1 - RiPP-like

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Location: 2,875 - 13,687 nt. (total: 10,813 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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Gene overview

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SubClusterBlast

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: synthase

CDS_03261: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

Hydrolases: synthase

CDS_03261: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002788.2	0.26	PKS	14-hydroxyisochainin	Streptomyces peucetius subsp. caesius ATCC 27952
BGC0000241.5	0.21	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora tropica CNB-440
BGC0001693.3	0.20	PKS	nenestatin	Micromonospora echinospora
BGC0000240.5	0.20	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora pacifica

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002788.2	0.26	PKS	14-hydroxyisochainin	Streptomyces peucetius subsp. caesius ATCC 27952
BGC0000241.5	0.21	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora tropica CNB-440
BGC0001693.3	0.20	PKS	nenestatin	Micromonospora echinospora
BGC0000240.5	0.20	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora pacifica

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.11 out of 23.79

Confidence: medium

Additional weak hits (1):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.18 out of 26.33

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism

NPDC021375.ctg-0006 - Region 2 - betalactone,terpene

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Location: 124,160 - 165,668 nt. (total: 41,509 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)
betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

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KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CDS_03366: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

CDS_03373: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase carboxylase

CDS_03370: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

CDS_03381: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: ligase synthetase

CDS_03367: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

CDS_03376: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002174.2	0.46	NRPS	ε-Poly-L-lysine	Epichloe festucae
BGC0001135.5	0.46	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.46	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001641.4	0.46	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002277.2	0.45	NRPS	atromentin	Suillus grevillei
BGC0001166.5	0.45	NRPS	HC-toxin	Alternaria jesenskae
BGC0000307.4	0.45	NRPS	AbT1	Aureobasidium pullulans
BGC0001251.4	0.45	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.45	NRPS	epichloenin A	Epichloe festucae
BGC0001132.4	0.45	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0002174.2	0.56	NRPS	ε-Poly-L-lysine	Epichloe festucae
BGC0001135.5	0.56	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.56	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001641.4	0.56	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002277.2	0.56	NRPS	atromentin	Suillus grevillei
BGC0001166.5	0.56	NRPS	HC-toxin	Alternaria jesenskae
BGC0000307.4	0.56	NRPS	AbT1	Aureobasidium pullulans
BGC0001251.4	0.56	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.56	NRPS	epichloenin A	Epichloe festucae

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

CDS_03364: PT_phytoene_like

Domain 1 (37 - 296): Prenyltransferase; Phytoene synthase like

Subtype: Hydroxysqualene synthase

Reactions:: PSPP → hydroxysqualene

CDS_03365: PT_phytoene_like

Domain 1 (4 - 279): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → diapophytoene; FPP → PSPP; FPP → squalene; GGPP → phytoene; PSPP → hydroxysqualene

CDS_03367: PT_FPPS_like

Domain 1 (51 - 332): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

CDS_03368: T2TS

Domain 1 (14 - 636): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.19 out of 20.47

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.19 out of 19.26

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.60 out of 19.26

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.67 out of 19.26

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 32.07 out of 36.53

Confidence: strong

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.59 out of 36.53

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.99 out of 20.47

Confidence: medium

Additional weak hits (10):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.62 out of 26.85

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.79 out of 30.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.30 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.59 out of 26.06

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 17.83 out of 25.88

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.16 out of 30.97

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.83 out of 28.19

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.79 out of 20.01

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.74 out of 29.72

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.87 out of 31.73

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
DmdR1	Iron(II)-dependent repressor
VqsM	Regulator of quorum-sensing signalling systems

NPDC021375.ctg-0006 - Region 3 - terpene

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Location: 223,146 - 244,210 nt. (total: 21,065 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

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SubClusterBlast

Terpene

TFBS Finder

Pfam domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

CDS_03449: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000595.3	0.30	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000709.5	0.26	saccharide	neomycin	Streptomyces fradiae ATCC 10745 = DSM 40063
BGC0002638.3	0.22	NRPS	misaugamycin A, misaugamycin B	Streptomyces sp. WAC 00631
BGC0002338.3	0.22	PKS	Sorangipyranone	Myxococcales bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000595.3	0.30	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000709.5	0.26	saccharide	neomycin	Streptomyces fradiae ATCC 10745 = DSM 40063
BGC0002638.3	0.22	NRPS	misaugamycin A, misaugamycin B	Streptomyces sp. WAC 00631
BGC0002338.3	0.22	PKS	Sorangipyranone	Myxococcales bacterium

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

No product predictions

Genes with terpene domains:

CDS_03449: T1TS

Domain 1 (2 - 320): Type 1 terpene synthase

Subtype: unknown

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.02 out of 23.79

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.25 out of 20.47

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.25 out of 20.47

Confidence: medium

Additional weak hits (8):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.97 out of 20.97

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.61 out of 24.78

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.30 out of 28.14

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.76 out of 21.84

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.29 out of 26.06

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.62 out of 26.12

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.26 out of 27.18

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.09 out of 29.65

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
VqsM	Regulator of quorum-sensing signalling systems

NPDC021375.ctg-0006 - Region 4 - T1PKS

Download region GenBank file

Download region SVG

Location: 415,207 - 488,020 nt. (total: 72,814 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CDS_03640: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

CDS_03647: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: PPTase acylase

CDS_03625: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

CDS_03626: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

CDS_03627: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

CDS_03630: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1060: 4'-phosphopantetheinyl transferase

Hydrolases: esterase hydrolase

CDS_03633: thioesterase

smcogs: SMCOG1004: thioesterase

CDS_03646: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Ligases: synthase

CDS_03624: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	0.74	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000041.3	0.72	PKS	oronofacic acid	Pseudomonas syringae
BGC0001160.5	0.66	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.66	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0002154.2	0.64	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.64	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	0.74	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000041.3	0.72	PKS	oronofacic acid	Pseudomonas syringae
BGC0001160.5	0.66	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.66	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0002154.2	0.64	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.64	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.71 out of 23.79

Confidence: medium

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 26.50 out of 30.12

Confidence: medium

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 24.12 out of 29.65

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.16 out of 18.46

Confidence: medium

Additional weak hits (14):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.83 out of 30.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.37 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.03 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.51 out of 29.38

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.11 out of 26.33

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.42 out of 26.12

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.56 out of 20.97

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.31 out of 35.63

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.15 out of 32.93

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.14 out of 27.04

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.58 out of 29.65

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.91 out of 28.14

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.88 out of 25.75

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 6, location 415206 - 488020:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - redmal) + (Me-ohmal - Me-ohmal) + (ccmal - Me-mal) + (Me-mal)
Non-colinear ordering:: CDS_03624 + CDS_03625 + CDS_03626 + CDS_03627

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_03624: mmal - mal

PKS_AT (546..846): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 215.0
Ethylmalonyl-CoA: 209.7
Methoxymalonyl-CoA: 181.8
2-Methylbutyryl-CoA: 148.7
trans-1,2-CPDA: 141.7
Propionyl-CoA: 132.9
Malonyl-CoA: 121.7
CHC-CoA: 100.1
Isobutyryl-CoA: 68.1
Benzoyl-CoA: 62.3
inactive: 38.0
Acetyl-CoA: 36.7
fatty_acid: 35.7
3-Methylbutyryl-CoA: 33.5

PKS_AT (1560..1857): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.3
inactive: 93.3
Methoxymalonyl-CoA: 58.9
Methylmalonyl-CoA: 48.0
Propionyl-CoA: 41.8
Isobutyryl-CoA: 22.2
Acetyl-CoA: 20.0
2-Methylbutyryl-CoA: 16.7
fatty_acid: 13.2
CHC-CoA: 9.0
Benzoyl-CoA: 8.9
Ethylmalonyl-CoA: 7.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

CDS_03625: mmal - mmal

PKS_AT (565..863): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 192.2
Ethylmalonyl-CoA: 178.9
Methoxymalonyl-CoA: 154.0
2-Methylbutyryl-CoA: 128.0
trans-1,2-CPDA: 112.9
Propionyl-CoA: 111.3
CHC-CoA: 91.8
Malonyl-CoA: 91.0
Isobutyryl-CoA: 63.2
3-Methylbutyryl-CoA: 49.9
Benzoyl-CoA: 49.8
inactive: 44.9
Acetyl-CoA: 41.4
fatty_acid: 39.5

PKS_AT (2103..2401): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 195.2
Ethylmalonyl-CoA: 185.8
Methoxymalonyl-CoA: 156.2
2-Methylbutyryl-CoA: 128.3
trans-1,2-CPDA: 115.0
Propionyl-CoA: 107.2
CHC-CoA: 102.1
Malonyl-CoA: 93.2
Isobutyryl-CoA: 68.1
Benzoyl-CoA: 53.9
3-Methylbutyryl-CoA: 51.0
Acetyl-CoA: 47.3
inactive: 41.2
fatty_acid: 41.1

CDS_03626: mal - mmal

PKS_AT (565..870): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 217.5
inactive: 110.6
Methoxymalonyl-CoA: 65.0
Methylmalonyl-CoA: 53.0
Benzoyl-CoA: 27.1
Acetyl-CoA: 26.2
Ethylmalonyl-CoA: 21.6
Propionyl-CoA: 21.2
Isobutyryl-CoA: 18.4
trans-1,2-CPDA: 12.5
CHC-CoA: 7.6
2-Methylbutyryl-CoA: 6.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2314..2612): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 196.7
Ethylmalonyl-CoA: 184.5
Methoxymalonyl-CoA: 160.5
2-Methylbutyryl-CoA: 130.2
trans-1,2-CPDA: 113.0
Propionyl-CoA: 112.1
CHC-CoA: 93.4
Malonyl-CoA: 88.3
Isobutyryl-CoA: 65.0
3-Methylbutyryl-CoA: 58.0
Benzoyl-CoA: 45.5
Acetyl-CoA: 43.5
fatty_acid: 41.8
inactive: 36.3

CDS_03627: mmal

PKS_AT (565..863): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.0
Ethylmalonyl-CoA: 189.7
Methoxymalonyl-CoA: 158.6
2-Methylbutyryl-CoA: 143.9
trans-1,2-CPDA: 123.3
Propionyl-CoA: 118.0
CHC-CoA: 103.8
Malonyl-CoA: 98.3
Isobutyryl-CoA: 69.5
3-Methylbutyryl-CoA: 58.5
Benzoyl-CoA: 53.9
Acetyl-CoA: 48.3
fatty_acid: 45.3
inactive: 43.9

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
LexA variant 1	Repressor of DNA damage response
MexT	Global virulence regulator
OsdR	Development and stress management regulator
RpoN	Regulator of nitrogen assimilation and virulence

NPDC021375.ctg-0007 - Region 1 - NRPS-like,T1PKS

Download region GenBank file

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Location: 40,880 - 89,183 nt. (total: 48,304 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CDS_03782: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Hydrolases: esterase hydrolase

CDS_03767: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

CDS_03776: putative esterase

smcogs: SMCOG1104: putative esterase

Isomerases: racemase

CDS_03759: mandelate racemase/muconate lactonizing enzyme

smcogs: SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Ligases: synthase

CDS_03769: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: permease

CDS_03778: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001164.3	0.66	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.66	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002191.2	0.59	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002175.3	0.59	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.58	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001273.3	0.58	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.58	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.58	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.57	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001284.4	0.56	PKS	alternariol	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001164.3	0.66	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.66	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.62	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.89 out of 29.72

Confidence: medium

Additional weak hits (13):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.41 out of 20.97

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.50 out of 25.75

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.59 out of 26.85

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.81 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.26 out of 27.78

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.29 out of 28.14

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.70 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.32 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.46 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.75 out of 31.73

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.74 out of 28.14

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 19.95 out of 30.98

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.79 out of 29.65

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 40879 - 89183:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (AHBA - ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_03769: AHBA - mal

CAL_domain (35..454): AHBA

minowa: AHBA

Prediction, score:

AHBA: 210.3
shikimic_acid: 130.9
fatty_acid: 0.0
NH2: 0.0
Acetyl-CoA: 0.0

PKS_AT (1200..1494): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 176.5
inactive: 91.7
Methoxymalonyl-CoA: 62.6
Methylmalonyl-CoA: 48.8
Isobutyryl-CoA: 26.3
Propionyl-CoA: 13.3
Acetyl-CoA: 12.4
Benzoyl-CoA: 12.1
fatty_acid: 9.1
Ethylmalonyl-CoA: 8.5
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0
CHC-CoA: -4.4

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
NtrC	Nitrogen regulatory protein C

NPDC021375.ctg-0007 - Region 2 - NRPS,T1PKS

Download region GenBank file

Download region SVG

Location: 115,892 - 165,254 nt. (total: 49,363 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

CDS_03822: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

CDS_03823: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

CDS_03824: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

CDS_03825: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

CDS_03835: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: kinase

CDS_03815: glycerol kinase

smcogs: SMCOG1210: glycerol kinase

Hydrolases: dehalogenase hydrolase

CDS_03819: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

CDS_03839: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Ligases: synthase

CDS_03826: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.83	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.66	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001276.3	0.65	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.65	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.64	PKS	(-)-Mellein	Parastagonospora nodorum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.66	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.66	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (12):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.12 out of 29.38

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.22 out of 29.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.09 out of 29.38

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.23 out of 25.88

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.34 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.98 out of 29.38

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.97 out of 30.22

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.78 out of 29.38

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.50 out of 25.75

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.35 out of 26.06

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.93 out of 28.19

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 115891 - 165254:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk - Orn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_03826: pk - Orn

Search NORINE for peptide: strict or relaxed

PKS_AT (546..842): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; CE-Malonyl-CoA: 54.2%; Acetyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 112.7
Malonyl-CoA: 110.0
Methoxymalonyl-CoA: 104.0
Ethylmalonyl-CoA: 87.7
Isobutyryl-CoA: 86.4
trans-1,2-CPDA: 61.2
Acetyl-CoA: 60.9
Benzoyl-CoA: 60.4
Propionyl-CoA: 60.2
2-Methylbutyryl-CoA: 57.6
CHC-CoA: 47.1
fatty_acid: 45.1
inactive: 36.0
3-Methylbutyryl-CoA: 36.0

AMP-binding (2290..2705): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: DVGEIGSIDK
Nearest Stachelhaus code(s):: Orn DVGEIGSIDK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description

NPDC021375.ctg-0007 - Region 3 - NI-siderophore,lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 251,541 - 291,051 nt. (total: 39,511 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CDS_03946: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Hydrolases: hydrolase

CDS_03934: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

CDS_03935: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Lyases: cyclase

CDS_03943: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.42	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001579.4	0.38	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000525.5	0.37	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000528.5	0.37	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000516.4	0.35	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0002703.2	0.35	ribosomal	archalan α	Halorussus salinus
BGC0000527.5	0.35	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000503.5	0.33	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0000504.5	0.32	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002704.2	0.32	ribosomal	archalan β	Halorussus salinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.57	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000516.4	0.55	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0001579.4	0.55	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000527.5	0.54	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0002469.2	0.54	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0002005.2	0.51	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000590.5	0.51	ribosomal	microcin N	Escherichia coli
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000528.5	0.50	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001499.5	0.50	other (other)	aerobactin	Pantoea ananatis

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for CDS_03943

CDS_03945

Leader:

MSNPNDIDELIRAWKDEDLREELPGVVHPSGDIDLTMISGG

Core:

DVHTGKFARSTWLLSGPLCATVSFAAGCW

Core with dehydrations:

DVHDhbGKFARDhaDhbWLLDhaGPLCysADhbVDhaFAAGCysW

antiSMASH-DB 4.0 matches for CDS_03945

34.5%

NZ_SISU01000002.1:

Lanthipeptides: allorf_782985_783149_lanthipeptide

3

HTGKFARSTWLLSGPLCATVSFAA

26

H K RSTW+ S V+ AA

5

HFQKLGRSTWIQSAARLRPVALAA

28

20.5%

NC_015711.1:

Lanthipeptides: allorf_5214975_5215151_lanthipeptide

12

WLLSGPLCATVSFAAGCW

29

W+ S P+C F GCW

20

WMASVPVC----FHFGCW

33

20.5%

NZ_CP022203.1:

Lanthipeptides: allorf_3336084_3336251_lanthipeptide

12

WLLSGPLCATVSFAAGCW

29

W+ S P+C F GCW

20

WMASAPVC----FHFGCW

33

with 2 more sequence matches

14.3%

NZ_CP072384.1:

Lanthipeptides: allorf_0337653_0337835_lanthipeptide

6

KFARSTWLLSGPL

18

+FAR+ W ++G L

10

RFARTKWNIAGYL

22

12.5%

NZ_JACKVL010000013.1:

Lanthipeptides: allorf_1185207_1185365_lanthipeptide

3

HTGKFARSTWLLSGPLCA

20

+ ++++STW + PL +

22

YESRYSQSTWSRTPPLAS

39

MIBiG 4.0 matches for CDS_03945

13.8%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

15

SGPLCAT

21

+GPLC

1

TGPLCVA

7

CDS_03950

Leader:

MSKFPRRKSSYSA

Core:

TSNCVEARLRREEGVEVGDSKLSPRARRLTFTGSTWTAFLTDTRRSRG

Core with dehydrations:

DhbDhaNCysVEARLRREEGVEVGDDhaKLDhaPRARRLDhbFDhbGDhaDhbWDhbAFLDhbDDhbRRDhaRG

antiSMASH-DB 4.0 matches for CDS_03950

25.0%

NZ_KB900614.1:

Lanthipeptides: SALPAC6_RS0114115_lanthipeptide

19

DSKLSPRARRLTFTGSTWTAFLTDTR

44

DSK P L F + WT FLT+T+

5

DSK-DPNGPALLFGRTAWTNFLTETK

29

allorf_269931_270050

Leader:

MRNKSHVAKRSTRRRDTHSAA

Core:

CRTRSAPRRNGGPISIMV

Core with dehydrations:

CysRDhbRDhaAPRRNGGPIDhaIMV

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.37 out of 20.47

Confidence: medium

Additional weak hits (7):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.79 out of 29.25

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.76 out of 21.84

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.80 out of 19.26

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.46 out of 25.75

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.19 out of 25.75

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 35.63

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 15.77 out of 33.14

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Lanthipeptides

TFBS Finder

Core peptide predictions

CDS_03945 - Class II

Cleavage pHMM score: -3.90

RODEO score: 0

Monoisotopic mass: 2972.5 Da

Molecular weight: 2974.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2992.4 Da N = 1; 3010.4 Da N = 2; 3028.5 Da N = 3; 3046.5 Da N = 4

CDS_03950 - Class II

Cleavage pHMM score: -6.30

RODEO score: 0

Monoisotopic mass: 5208.8 Da

Molecular weight: 5211.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5229.8 Da N = 1; 5247.8 Da N = 2; 5265.8 Da N = 3; 5283.8 Da N = 4; 5301.8 Da N = 5; 5319.9 Da N = 6; 5337.9 Da N = 7; 5355.9 Da N = 8; 5373.9 Da N = 9; 5391.9 Da N = 10; 5410.0 Da N = 11

allorf_269931_270050 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 1916.0 Da

Molecular weight: 1917.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1935.3 Da N = 1; 1953.3 Da N = 2

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems

NPDC021375.ctg-0007 - Region 4 - NRP-metallophore,NRPS,terpene

Download region GenBank file

Download region SVG

Location: 316,882 - 396,677 nt. (total: 79,796 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

CDS_03983: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

CDS_04013: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

CDS_04034: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

CDS_04035: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: acyltransferase methyltransferase

CDS_03984: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

CDS_03987: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: deaminase hydrolase

CDS_03991: ornithine cyclodeaminase

smcogs: SMCOG1158: ornithine cyclodeaminase

CDS_04031: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Isomerases: isomerase

CDS_03982: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase

CDS_04018: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CDS_04019: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CDS_04020: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: transport

CDS_04028: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.84	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000342.4	0.84	NRPS	enniatin	Fusarium equiseti
BGC0001132.4	0.83	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.82	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.80	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.79	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.76	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.76	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001758.4	0.76	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001261.3	0.74	NRPS	AM-toxin	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000342.4	0.73	NRPS	enniatin	Fusarium equiseti
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.73	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.72	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.71	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.70	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001758.4	0.70	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
triterpene		squalene	C30	acyclic	none
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

CDS_03990: PT_phytoene_like

Domain 1 (18 - 316): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → diapophytoene; FPP → PSPP; FPP → squalene; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 30.62 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 30.65 out of 36.53

Confidence: medium

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 25.09 out of 30.12

Confidence: medium

Additional weak hits (23):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.22 out of 30.22

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.77 out of 28.14

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.57 out of 26.33

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.36 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.81 out of 26.06

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.44 out of 30.22

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.81 out of 31.73

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.94 out of 33.73

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.11 out of 27.78

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.56 out of 39.62

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.06 out of 31.73

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.29 out of 18.57

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.14 out of 19.26

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.28 out of 33.14

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 20.42 out of 22.40

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.58 out of 28.14

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.08 out of 32.93

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.11 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.86 out of 33.14

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.70 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 26.40 out of 36.53

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.66 out of 29.65

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.17 out of 29.65

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Terpene

TFBS Finder

Predicted core structure(s)

For candidate cluster 6, location 316881 - 396677:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser) + (X - X) + (NMe-OH-Orn - OH-Orn)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 8, location 330825 - 396677:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser) + (X - X) + (NMe-OH-Orn - OH-Orn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_04018: OH-Orn - OH-Orn

Search NORINE for peptide: strict or relaxed

AMP-binding (884..1300): OH-Orn

nrpys: OH-Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: DMENLGLINK
Nearest Stachelhaus code(s):: OH-Orn DMENLGLINK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2398..2815): OH-Orn

nrpys: OH-Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: DMENLGLINK
Nearest Stachelhaus code(s):: OH-Orn DMENLGLINK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

CDS_04019: X - X

AMP-binding (504..906): X

nrpys: me-bAla, bAla

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: IDTTISLGDK
Nearest Stachelhaus code(s):: me-bAla LDTTVSLGDK (74% 8Å match); bAla VDTVISLGDK (62% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1567..1967): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHLGTITK
Nearest Stachelhaus code(s):: Ser DVWHLSLIDK (76% 8Å match); Hpg DIWHVGAITK (59% 8Å match)
Stachelhaus code match:: 70% (weak)

CDS_04020: Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (565..991): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNLGLIHK
Nearest Stachelhaus code(s):: Ser DLFNLGLIHK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
DmdR1	Iron(II)-dependent repressor
OsdR	Development and stress management regulator

NPDC021375.ctg-0007 - Region 5 - CDPS

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Location: 429,047 - 449,823 nt. (total: 20,777 nt) Show pHMM detection rules used

CDPS: CDPS

Legend:

core biosynthetic genes

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transport-related genes

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other genes

resistance

TTA codons

binding site

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Select a gene to view the details available for it

Gene overview

Tailoring

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TFBS Finder

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

CDS_04085: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

Transferases: glycosyltransferase methyltransferase

CDS_04072: methyltransferase

smcogs: SMCOG1089: methyltransferase

CDS_04080: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Hydrolases: dehalogenase

CDS_04077: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001948.3	0.49	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0002103.2	0.46	other (other)	pulcherriminic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0001534.3	0.42	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0000843.5	0.42	other (non-nrp beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate	Streptomyces clavuligerus ATCC 27064
BGC0001483.4	0.41	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0002343.3	0.40	other (other), ribosomal	ammosester A, ammosester B, ammosester C, ammosamaic acid cogener	Streptomyces uncialis
BGC0001521.3	0.40	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000874.5	0.39	other (other)	blasticidin S	Streptomyces griseochromogenes
BGC0002294.3	0.37	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0002509.3	0.37	NRPS	montamide A, capsimycin, clifednamide A, frontalamide A, combamide A	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001948.3	0.49	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0002103.2	0.46	other (other)	pulcherriminic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0001534.3	0.42	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0000843.5	0.42	other (non-nrp beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate	Streptomyces clavuligerus ATCC 27064
BGC0001483.4	0.41	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0002343.3	0.40	other (other), ribosomal	ammosester A, ammosester B, ammosester C, ammosamaic acid cogener	Streptomyces uncialis
BGC0001521.3	0.40	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000874.5	0.39	other (other)	blasticidin S	Streptomyces griseochromogenes
BGC0002294.3	0.37	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0002509.3	0.37	NRPS	montamide A, capsimycin, clifednamide A, frontalamide A, combamide A	Streptomyces sp.

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.15 out of 26.85

Confidence: medium

Additional weak hits (8):

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.23 out of 29.65

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.05 out of 29.65

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.86 out of 28.19

Confidence: weak

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 17.99 out of 25.31

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.01 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 30.11

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.07 out of 31.73

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.07 out of 33.73

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
RutR	Regulator of the pyrimidine and purine metabolism

NPDC021375.ctg-0008 - Region 1 - terpene

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Location: 13,767 - 36,510 nt. (total: 22,744 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

binding site

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Select a gene to view the details available for it

Gene overview

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Terpene

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CDS_04210: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: methyltransferase

CDS_04220: methyltransferase

smcogs: SMCOG1089: methyltransferase

Lyases: cyclase hydratase

CDS_04215: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

CDS_04221: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.56	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000894.4	0.46	other (other)	citrinin	Monascus aurantiacus
BGC0000866.5	0.45	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000231.5	0.44	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000671.3	0.43	terpene	momilactone B	Oryza sativa Japonica Group
BGC0001483.4	0.43	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0002651.2	0.42	terpene	sordaricin B	Rosellinia necatrix
BGC0000234.5	0.42	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002218.2	0.41	terpene	(-)-Cyatha-3,12-diene	Dentipellis sp. KUC8613
BGC0001723.5	0.38	PKS	oviedomycin	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.56	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000894.4	0.46	other (other)	citrinin	Monascus aurantiacus
BGC0000866.5	0.45	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000231.5	0.44	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000671.3	0.43	terpene	momilactone B	Oryza sativa Japonica Group
BGC0001483.4	0.43	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0002651.2	0.42	terpene	sordaricin B	Rosellinia necatrix
BGC0000234.5	0.42	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002218.2	0.41	terpene	(-)-Cyatha-3,12-diene	Dentipellis sp. KUC8613
BGC0001723.5	0.38	PKS	oviedomycin	Streptomyces antibioticus

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene	drimane-type		C15	C2-C7 + C6-C11	PP

Genes with terpene domains:

CDS_04215: T1TS

Domain 1 (3 - 317): Type 1 terpene synthase

Subtype: unknown

CDS_04216: T2TS

Domain 1 (24 - 509): Type 2 terpene synthase

Subtype: Sesquiterpene synthase, group b

Reactions:: FPP → sesquiterpene_C2-C7/C6-C11_PP

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 24.85 out of 30.12

Confidence: medium

Additional weak hits (5):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.36 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.49 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.89 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.74 out of 27.78

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.63 out of 21.55

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
AfsR	Pleiotropic regulatory for antibiotic production
OsdR	Development and stress management regulator

NPDC021375.ctg-0008 - Region 2 - terpene

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Location: 232,992 - 255,307 nt. (total: 22,316 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

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ClusterBlast

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Terpene

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

CDS_04411: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: aminotransferase kinase transferase

CDS_04424: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

CDS_04428: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

CDS_04429: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Hydrolases: hydrolase

CDS_04412: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Lyases: cyclase

CDS_04421: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Ligases: synthase

CDS_04427: 3-dehydroquinate synthase

smcogs: SMCOG1183: 3-dehydroquinate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001181.4	0.81	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0001746.3	0.75	terpene	pristinol	Streptomyces pristinaespiralis ATCC 25486
BGC0000701.5	0.51	saccharide	jinggangmycin	Streptomyces hygroscopicus subsp. yingchengensis
BGC0001197.5	0.45	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000706.3	0.42	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001483.4	0.42	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0000906.3	0.40	other (other)	heme D1	Heliophilum fasciatum
BGC0000905.5	0.40	other (other)	heme D1	Heliobacillus mobilis
BGC0001910.4	0.40	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0002439.3	0.39	other (other)	diastaphenazine, izumiphenazine C	Streptomyces diastaticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001181.4	0.81	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0001746.3	0.75	terpene	pristinol	Streptomyces pristinaespiralis ATCC 25486
BGC0000701.5	0.51	saccharide	jinggangmycin	Streptomyces hygroscopicus subsp. yingchengensis
BGC0001197.5	0.45	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000706.3	0.42	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001483.4	0.42	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0000906.3	0.40	other (other)	heme D1	Heliophilum fasciatum
BGC0000905.5	0.40	other (other)	heme D1	Heliobacillus mobilis
BGC0001910.4	0.40	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0002439.3	0.39	other (other)	diastaphenazine, izumiphenazine C	Streptomyces diastaticus

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene		germacradienol	C15	C1-C10	OH
sesquiterpene		geosmin	C12	C1-C10	OH

Genes with terpene domains:

CDS_04421: T1TS + T1TS

Domain 1 (2 - 326): Type 1 terpene synthase

Subtype: Geosmin synthase, N terminal domain

Reactions:: FPP → germacradienol

Domain 2 (346 - 707): Type 1 terpene synthase

Subtype: Geosmin synthase, C terminal domain

Reactions:: germacradienol → geosmin

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (4):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.29 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.06 out of 30.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.09 out of 27.78

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.89 out of 24.78

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate

TFBS definitions

Regulator	Description

NPDC021375.ctg-0008 - Region 3 - HR-T2PKS,phosphonate

Download region GenBank file

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Location: 422,336 - 464,735 nt. (total: 42,400 nt) Show pHMM detection rules used

HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))
phosphonate: (phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase or phosphonatesMeIsocitrateLyase))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidase

CDS_04594: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

CDS_04600: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: transketolase

CDS_04597: transketolase

smcogs: SMCOG1204: transketolase

Hydrolases: hydrolase

CDS_04587: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Ligases: synthase

CDS_04598: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000897.5	0.34	other (other)	dehydrophos	Streptomyces luridus
BGC0002036.4	0.33	other (other)	dehydrofosmidomycin	Streptomyces lavendulae
BGC0000937.5	0.32	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0000904.5	0.28	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0001859.4	0.28	other (phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000665.5	0.27	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0001739.3	0.25	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0000926.5	0.24	other (other)	rhizocticin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000221.5	0.24	PKS	erdacin	uncultured soil bacterium V167
BGC0000666.5	0.24	terpene	xiamycin A	Streptomyces sp. SCSIO 02999

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000897.5	0.49	other (other)	dehydrophos	Streptomyces luridus
BGC0002036.4	0.49	other (other)	dehydrofosmidomycin	Streptomyces lavendulae
BGC0000937.5	0.49	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0000231.5	0.47	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001859.4	0.46	other (phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000234.5	0.46	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001507.3	0.45	ribosomal	anantin C	Streptomyces olindensis
BGC0000904.5	0.45	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0001506.5	0.45	ribosomal	anantin B1, anantin B2	Streptomyces sp. NRRL S-146
BGC0002711.2	0.45	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.07 out of 24.78

Confidence: medium

Additional weak hits (9):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.11 out of 26.33

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.29 out of 29.38

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.70 out of 26.33

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.71 out of 27.04

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.98 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.13 out of 24.78

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.30 out of 29.25

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 15.71 out of 33.14

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.98 out of 29.65

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
LexA variant 2	Repressor of DNA damage response

NPDC021375.ctg-0009 - Region 1 - NAPAA,T1PKS,hglE-KS

Download region GenBank file

Download region SVG

Location: 1 - 64,379 nt. (total: 64,379 nt) Show pHMM detection rules used

Region on contig edge.

NAPAA: (AMP-binding and TIGR02353)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
hglE-KS: (hglE or hglD)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CDS_04680: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: glycosyltransferase

CDS_04696: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Hydrolases: amidase hydrolase

CDS_04686: amidase

smcogs: SMCOG1105: amidase

CDS_04688: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

CDS_04697: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Ligases: ligase synthase

CDS_04678: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_04700: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: transporter

CDS_04703: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001160.5	0.55	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.55	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002276.2	0.52	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000037.4	0.51	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0002174.2	0.48	NRPS	ε-Poly-L-lysine	Epichloe festucae
BGC0002171.2	0.46	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275.2	0.46	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0000863.3	0.39	other (other)	eicosapentaenoic acid	Pseudoalteromonas sp. DS-12
BGC0000393.5	0.37	NRPS, PKS	myxoprincomide-c506	Myxococcus xanthus DK 1622
BGC0002648.2	0.37	PKS	eicosapentaenoic acid	Shewanella sp. N2AIL

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002174.2	0.77	NRPS	ε-Poly-L-lysine	Epichloe festucae
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001135.5	0.61	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002276.2	0.61	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0002135.2	0.60	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001268.4	0.60	NRPS, PKS	fusarin C	Fusarium fujikuroi

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.11 out of 23.79

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.75 out of 23.05

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

Additional weak hits (15):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.19 out of 18.57

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.04 out of 25.88

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.81 out of 21.84

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.18 out of 27.55

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.21 out of 30.22

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.28 out of 27.78

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.60 out of 30.98

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.00 out of 29.65

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 18.52 out of 26.12

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.10 out of 36.53

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.95 out of 29.65

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 21.56 out of 27.18

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 15.67 out of 33.14

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 64379:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-mal) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 24281:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 10004 - 64379:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal)
Non-colinear ordering:: CDS_04699 + CDS_04698

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_04678: X

AMP-binding (40..413): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAESIGTVVK
Nearest Stachelhaus code(s):: Lys DAEDIGTVVK (71% 8Å match); Gln or Tyr DAESVGTVVK (65% 8Å match)
Stachelhaus code match:: 90% (moderate)

CDS_04699: mmal

PKS_AT (980..1193): mmal

ATSignature: (unknown)

No matches above 50%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 21.1
Methoxymalonyl-CoA: 14.4
inactive: 12.7
Malonyl-CoA: 9.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

CDS_04700: mal

PKS_AT (1210..1500): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 90.8
Methoxymalonyl-CoA: 47.0
Methylmalonyl-CoA: 37.8
Ethylmalonyl-CoA: 26.9
inactive: 24.9
CHC-CoA: 19.3
Propionyl-CoA: 13.9
trans-1,2-CPDA: 8.8
fatty_acid: 8.1
Isobutyryl-CoA: 4.9
2-Methylbutyryl-CoA: 0.3
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism

NPDC021375.ctg-0009 - Region 2 - lanthipeptide-class-iv

Download region GenBank file

Download region SVG

Location: 122,907 - 145,870 nt. (total: 22,964 nt) Show pHMM detection rules used

lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CDS_04780: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Isomerases: mutase

CDS_04784: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000551.5	0.58	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000519.4	0.58	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000496.5	0.57	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000501.3	0.57	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000513.3	0.54	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000528.5	0.54	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000563.4	0.53	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.53	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000503.5	0.49	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002700.2	0.49	ribosomal	bacinapeptin	Bacillus nakamurai

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000551.5	0.58	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000519.4	0.58	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000496.5	0.57	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000501.3	0.57	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000513.3	0.54	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000528.5	0.54	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000563.4	0.53	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.53	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000503.5	0.49	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002700.2	0.49	ribosomal	bacinapeptin	Bacillus nakamurai

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 18.89 out of 25.31

Confidence: medium

Additional weak hits (8):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 17.99 out of 26.33

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 18.89 out of 27.55

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.88 out of 19.26

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.10 out of 28.14

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.69 out of 20.97

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.57 out of 26.33

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.36 out of 28.19

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.57 out of 24.78

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Lanthipeptides

TFBS Finder

Core peptide predictions

No core peptides found.

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor

NPDC021375.ctg-0009 - Region 3 - NI-siderophore

Download region GenBank file

Download region SVG

Location: 173,928 - 207,678 nt. (total: 33,751 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

CDS_04828: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

Transferases: aminotransferase

CDS_04824: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: deformylase peptidase

CDS_04818: gamma-glutamyltranspeptidase

smcogs: SMCOG1274: gamma-glutamyltranspeptidase

CDS_04836: peptide deformylase

smcogs: SMCOG1275: peptide deformylase

Lyases: decarboxylase hydratase

CDS_04825: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

CDS_04830: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001572.3	0.64	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002633.2	0.64	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0001478.5	0.62	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002683.2	0.62	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0002692.2	0.61	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000941.3	0.60	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002469.2	0.59	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001531.5	0.58	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0002305.2	0.57	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001713.5	0.55	other (other)	ochrobactin	Ochrobactrum anthropi

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001572.3	0.64	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002633.2	0.64	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0001478.5	0.62	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002683.2	0.62	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0002692.2	0.61	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000941.3	0.60	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002469.2	0.59	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001531.5	0.58	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0002305.2	0.57	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001713.5	0.55	other (other)	ochrobactin	Ochrobactrum anthropi

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26

Confidence: strong

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 29.03 out of 36.53

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.93 out of 24.78

Confidence: medium

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 25.49 out of 29.65

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 22.81 out of 27.18

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 23.31 out of 27.18

Confidence: medium

Additional weak hits (10):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.70 out of 26.33

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.00 out of 31.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.22 out of 30.25

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.55 out of 24.78

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.41 out of 30.11

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.34 out of 35.63

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.09 out of 29.65

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.77 out of 25.88

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.32 out of 24.78

Confidence: weak

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 17.99 out of 25.31

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
DmdR1	Iron(II)-dependent repressor
LexA variant 1	Repressor of DNA damage response
LexA variant 2	Repressor of DNA damage response
NrdR	Represses ribonucleotide reductase encoding genes

NPDC021375.ctg-0009 - Region 4 - NI-siderophore

Download region GenBank file

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Location: 328,616 - 358,529 nt. (total: 29,914 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthase

CDS_04962: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001948.3	0.43	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000942.4	0.40	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001713.5	0.40	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0000295.5	0.38	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002692.2	0.38	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0001810.3	0.37	PKS	trehangelin	Polymorphospora rubra
BGC0002227.3	0.36	NRPS	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0001888.2	0.36	other (other)	mannosylerythritol lipid A, mannosylerythritol lipid B, mannosylerythritol lipid C	Ustilago maydis 521
BGC0002471.3	0.36	other (other)	baumannoferrin A, baumannoferrin B	Acinetobacter baumannii AYE
BGC0000277.5	0.35	PKS	urdamycin	Streptomyces fradiae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001948.3	0.43	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000942.4	0.40	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001713.5	0.40	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0000295.5	0.38	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002692.2	0.38	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0001810.3	0.37	PKS	trehangelin	Polymorphospora rubra
BGC0002227.3	0.36	NRPS	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0001888.2	0.36	other (other)	mannosylerythritol lipid A, mannosylerythritol lipid B, mannosylerythritol lipid C	Ustilago maydis 521
BGC0002471.3	0.36	other (other)	baumannoferrin A, baumannoferrin B	Acinetobacter baumannii AYE
BGC0000277.5	0.35	PKS	urdamycin	Streptomyces fradiae

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.12 out of 23.79

Confidence: medium

Additional weak hits (8):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.35 out of 29.38

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.07 out of 21.84

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.04 out of 27.78

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 22.40

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.50 out of 28.14

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.93 out of 23.43

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.27 out of 20.01

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.72 out of 30.98

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism

NPDC021375.ctg-0010 - Region 1 - NI-siderophore

Download region GenBank file

Download region SVG

Location: 27,940 - 59,455 nt. (total: 31,516 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CDS_05111: dehydrogenase

smcogs: SMCOG1072: dehydrogenase

Hydrolases: hydrolase

CDS_05127: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Lyases: decarboxylase

CDS_05118: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000946.5	0.66	other (other)	vibrioferrin	Vibrio parahaemolyticus
BGC0002527.2	0.63	other (other)	vibrioferrin	Azotobacter vinelandii CA
BGC0001408.5	0.60	other (other)	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000947.5	0.58	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0002469.2	0.53	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0000941.3	0.52	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002305.2	0.52	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0000943.5	0.49	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002692.2	0.49	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0001498.5	0.49	other (other)	aerobactin	Xenorhabdus szentirmaii DSM 16338

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000946.5	0.66	other (other)	vibrioferrin	Vibrio parahaemolyticus
BGC0002527.2	0.63	other (other)	vibrioferrin	Azotobacter vinelandii CA
BGC0001408.5	0.60	other (other)	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000947.5	0.58	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0002469.2	0.53	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0000941.3	0.52	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002305.2	0.52	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0000943.5	0.49	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002692.2	0.49	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0001498.5	0.49	other (other)	aerobactin	Xenorhabdus szentirmaii DSM 16338

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 24.10 out of 27.04

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.73 out of 36.53

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.27 out of 25.31

Confidence: medium

Additional weak hits (11):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.85 out of 21.55

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.93 out of 30.97

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.42 out of 30.25

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.56 out of 21.84

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 15.62 out of 33.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.15 out of 28.19

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.07 out of 30.98

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.38 out of 36.53

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 15.96 out of 33.14

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CatR	H2O2-responsive repressor
DasR	N-acetylglucosamine dependent repressor
DmdR1	Iron(II)-dependent repressor

NPDC021375.ctg-0010 - Region 2 - NRPS,lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 60,391 - 115,972 nt. (total: 55,582 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

CDS_05143: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

CDS_05161: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: halogenase

CDS_05147: halogenase

smcogs: SMCOG1119: halogenase

Hydrolases: deacetylase hydrolase

CDS_05140: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

CDS_05166: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Lyases: cyclase

CDS_05154: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Isomerases: racemase

CDS_05138: mandelate racemase/muconate lactonizing enzyme

smcogs: SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Ligases: ligase

CDS_05149: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_05150: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CDS_05151: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_05152: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001250.4	0.72	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.72	NRPS	epichloenin A	Epichloe festucae
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0002075.3	0.69	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.69	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002164.2	0.68	NRPS	peramine	Epichloe festucae
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.74	NRPS	dimethylcoprogen	Alternaria alternata
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.72	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.71	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.69	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for CDS_05154

CDS_05153

Leader:

MRTASNAA

Core:

RNTVVNAWRSGAESADGVENPAGSLYIGGSATEQGLTEIDVAAISCGTACSWSRTRACC

Core with dehydrations:

RNDhbVVNAWRDhaGAEDhaADGVENPAGDhaLYIGGDhaADhbEQGLDhbEIDVAAIDhaCysGDhbACysDhaWDhaRDhbRACysCys

antiSMASH-DB 4.0 matches for CDS_05153

59.3%

NZ_BIFH01000038.1:

Lanthipeptides: EMA17_RS39120_lanthipeptide

25

LYIGGSATEQGLTEIDVAAISCGTACSWSRTRACC

59

LYIGGSATEQGLTEIDVAAISCGTACSWSRTRACC

1

LYIGGSATEQGLTEIDVAAISCGTACSWSRTRACC

35

52.5%

NZ_JAIQCM010000003.1:

Lanthipeptides: K9V56_RS08295_lanthipeptide

4

VVNAWRSGAESADGVENPAGSLYIGGSATEQGLTEIDVAAIS--CGTACSWSRTRACC

59

+V WRS ADG NPAG L+IGG E + D + IS CGTACS SRTR CC

1

LVAQWRS---QADG-SNPAGPLFIGGEYAEADIVG-DTSTISGKCGTACSGSRTRMCC

53

50.8%

NZ_CP071090.1:

Lanthipeptides: JY651_RS36970_lanthipeptide

8

WRSGAESADGVENPAGSLYIGGSATEQGLTEIDVAAISCGTACSW---SRTRACC

59

W SG+ES DG+ NPAG LY+GG+ATE LT+ AA GT CS SR CC

1

WLSGSESVDGLANPAGPLYVGGTATEAALTD---AAPMMGTGCSICTASRPVVCC

52

with 62 more sequence matches

Only the first 10 are displayed here.

47.5%

NZ_CP040709.1:

Lanthipeptides: FF090_RS18940_lanthipeptide

8

WRSGAESADGVENPAGSLYIGGSATEQGLTEIDVAAIS--CGTACSWSRTRACC

59

WRS A+++ NPAG L+IGG E + D +IS CGTACS SRTR CC

2

WRSQADAS----NPAGPLFIGGEYAEADIIG-DTTSISGKCGTACSGSRTRMCC

50

44.1%

NZ_CP012109.1:

Lanthipeptides: A176_RS31295_lanthipeptide

8

WRSGAESADGVENPAGSLYIGGSATEQGLTEIDVAAISCGTACSWSRTRACC

59

W SG+E A GV NPAG LY+GG ATE LT+ + + ++CS S T CC

1

WLSGSEEAHGVSNPAGPLYVGGDATEAALTDESLMIFTGCSSCSASGTGFCC

52

42.4%

NZ_CP012109.1:

Lanthipeptides: A176_RS18020_lanthipeptide

4

VVNAWRSGAESADGVENPAGSLYIGGSATEQGLT-EIDVAAISCGTACSWSRTRACC

59

+V WR+ A+ + NPAG L++GG TE + E V + CGT CS S+TR CC

2

LVEQWRNSADKS----NPAGPLFVGGEFTESDIIHETIVISGRCGTGCSGSQTRQCC

54

42.4%

NZ_CP069338.1:

Lanthipeptides: JQX13_RS07220_lanthipeptide

8

WRSGAESADGVENPAGSLYIGGSATEQGLTEIDVAAISCGTACSWSRTRACC

59

W SG+ESA G+ NPAG LY+GG ATE LT A + ++C+ S CC

1

WLSGSESAFGMNNPAGPLYLGGEATEAALTNSTDALYTGCSSCTGSLHSYCC

52

39.0%

NZ_CP063231.1and 1 other:

NZ_FPIS01000001.1 Lanthipeptides: BT115_RS02490_lanthipeptide

Lanthipeptides: IM816_RS09045_lanthipeptide

8

WRSGAESADGVENPAGSLYI-GGSATEQGLTEIDVAAISCGTACSWSRTRACC

59

W SGA++ G +NPAG LY G + T +T D+A IS ++C+ SR CC

1

WLSGADNVGGYDNPAGPLYTEGHNQTLMAMTSTDIALISNCSSCTASRPGVCC

53

39.0%

NZ_FOSG01000018.1and 1 other:

NZ_PDKQ02000037.1 Lanthipeptides: BFM75_RS14295_lanthipeptide

Lanthipeptides: BM237_RS22045_lanthipeptide

8

WRSGAESADGVENPAGSLYIGGSATEQGLTEIDVAAISCGTACSWSRTRACC

59

W GAE++ G NPAG LY+GG+ATE L + A + ++C+ S T CC

1

WLDGAENSHGEPNPAGPLYVGGAATEAALVDATDALFTACSSCTGSLTTFCC

52

37.3%

NZ_AP014940.1:

Lanthipeptides: LEN_RS25395_lanthipeptide

8

WRSGAESADGVENPAGSLYIGGSATEQGLTEIDVAAISCGTA-CSWSRTRACC

59

WR+ A G +NPAG L+IGG E + D AIS T+ C+ T CC

1

WRNEA----GSDNPAGPLFIGGEFAEADIAG-DSEAISMITSVCTGCGTIQCC

48

37.3%

NZ_BMQJ01000023.1:

Lanthipeptides: IEZ10_RS33030_lanthipeptide

8

WRSGAESADGVENPAGSLYIGGSATEQGLTEIDVAAISCGTACSWSRTRACC

59

WRSGA+ +G +NPAG L+IG A +EI + A+ A S + +R CC

1

WRSGAD-VEGWDNPAGPLFIGDYAE----SEITLTALDTRLASSCTCSRFCC

47

37.3%

NZ_CP093340.1:

Lanthipeptides: MNO14_RS04685_lanthipeptide

8

WRSGAESADGVENPAGSLYIGG-SATEQGLTEIDVAAISCGTACSWSRTRACC

59

W SGA++ DG ENPAG+LY+ G +ATE +T+ ++ ++C+ S CC

1

WLSGADTVDGYENPAGALYVEGIAATEAAMTDKSFLLLTQCSSCTASIPAHCC

53

37.3%

NZ_JABBWY010000002.1:

Lanthipeptides: HHX37_RS08020_lanthipeptide

8

WRSGAESADGVENPAGSLYIGGSA-TEQGLTEIDVAAISCGTACSWSRTRACC

59

WRSGA+ +G + PAG L+IG A +E LT +D S +C+ + T CC

1

WRSGAD-VEGWDCPAGPLFIGEYAESEITLTALDTRRPS---SCTGANTIPCC

49

MIBiG 4.0 matches for CDS_05153

18.6%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

20

NPAGSLYIGGSATEQGLTEIDVAAISCGTACSWSR

54

+PA + I G Q + V+A C T SR

2

DPAVTGLILGIVAIQAGVAVGVSAAFCPTTKCTSR

36

8.5%

BGC0001155.5 (AGY49587.1):

Thiopeptide: GE2270

46

CGTACSWS

53

CG CS S

6

CGFCCSCS

13

6.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

47

GTACSWSRTRACC

59

AC + CC

37

APACHTLSSLPCC

49

allorf_096024_096110

Leader:

MRKRRGRRRAHAG

Core:

QRKCRTGTADPAMER

Core with dehydrations:

QRKCysRDhbGDhbADPAMER

antiSMASH-DB 4.0 matches for allorf_096024_096110

30.0%

NZ_CP101913.1:

Lanthipeptides: allorf_1820059_1820208_lanthipeptide

4

CRTGTADPAMER

15

CR T DP + R

2

CRARTCDPLLVR

13

19.4%

NC_009621.1:

Lanthipeptides: allorf_1016269_1016397_lanthipeptide

2

RKCRTGTADPAMER

15

R+C G+AD +R

13

RRCFRGSADECFKR

26

17.9%

NZ_KI632511.1and 1 other:

NZ_KI632511.1 Lanthipeptides: ACTRO_RS29755_lanthipeptide

Lanthipeptides: ACTRO_RS29755_lanthipeptide

1

QRKCRTGTADPA

12

C TG+ DP+

17

NSACATGSNDPS

28

with 2 more sequence matches

16.3%

NZ_CP110813.1:

Lanthipeptides: allorf_0964079_0964300_lanthipeptide

2

RKCRTGTADPA

12

R C GT DPA

19

RSCEAGTGDPA

29

14.0%

NZ_CP067396.1:

Lanthipeptides: allorf_0994793_0995014_lanthipeptide

2

RKCRTGTADP

11

R C GT DP

19

RSCEAGTGDP

28

allorf_108741_108905

Leader:

MIVPEPEPEPEQGGVREAAFAVRGGLAAARVGLVDREVVAEVVTLCAVAGS

Core:

TCS

Core with dehydrations:

DhbCysDha

allorf_108902_109012

Leader:

MSSSAGS

Core:

HARPWGRAREAGHGTECEGVHCLMHRLPG

Core with dehydrations:

HARPWGRAREAGHGDhbECysEGVHCysLMHRLPG

MIBiG 4.0 matches for allorf_108902_109012

13.8%

BGC0000563.4 (AEA03263.1):

Lanthipeptide: venezuelin

15

TECEGVHC

22

T C G+ C

14

TVCIGISC

21

13.8%

BGC0002150.2 (MBO0654592.1):

Lasso peptide: triculamin

7

RAREAGHGTECEGVH

21

+ + G G +GV

2

KKSKPGDGIRGKGVR

16

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 24.79 out of 27.04

Confidence: strong

Additional weak hits (16):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 17.93 out of 25.88

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.82 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.28 out of 28.14

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.45 out of 29.25

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 17.95 out of 36.54

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.89 out of 27.55

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.36 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.40 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.35 out of 31.73

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.82 out of 30.98

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.84 out of 35.63

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 17.16 out of 22.40

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.99 out of 18.57

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.20 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.63 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.47 out of 28.14

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

Lanthipeptides

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Core peptide predictions

CDS_05153 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 5801.8 Da

Molecular weight: 5805.3 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 5823.3 Da N = 1; 5841.3 Da N = 2; 5859.4 Da N = 3; 5877.4 Da N = 4; 5895.4 Da N = 5; 5913.4 Da N = 6; 5931.4 Da N = 7; 5949.5 Da N = 8

allorf_096024_096110 - Class II

Cleavage pHMM score: -7.20

RODEO score: 0

Monoisotopic mass: 1682.8 Da

Molecular weight: 1683.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1701.9 Da N = 1

allorf_108741_108905 - Class II

Cleavage pHMM score: -4.40

RODEO score: 0

Monoisotopic mass: 273.1 Da

Molecular weight: 273.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 291.3 Da N = 1

allorf_108902_109012 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 3201.5 Da

Molecular weight: 3203.6 Da

Number of bridges: 1

Predicted core structure(s)

For candidate cluster 2, location 60390 - 115972:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Gly) + (X) + (Asp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_05149: Asp

Search NORINE for peptide: strict or relaxed

AMP-binding (511..913): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DFTKIGHVGK
Nearest Stachelhaus code(s):: Asp DLTKIGHVGK (65% 8Å match)
Stachelhaus code match:: 90% (moderate)

CDS_05150: X

AMP-binding (493..906): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DTEDIGTVIK
Nearest Stachelhaus code(s):: Lys DTCDIGTVIK (71% 8Å match)
Stachelhaus code match:: 90% (moderate)

CDS_05151: Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (469..883): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DIVQVGAVWK
Nearest Stachelhaus code(s):: Gly DILQLGVVWK (79% 8Å match)
Stachelhaus code match:: 70% (weak)

CDS_05152: X

AMP-binding (76..489): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: NATFGTSPAK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
DasR	N-acetylglucosamine dependent repressor

NPDC021375.ctg-0010 - Region 3 - lanthipeptide-class-i

Download region GenBank file

Download region SVG

Location: 147,264 - 171,836 nt. (total: 24,573 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

CDS_05196: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

CDS_05202: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Lyases: cyclase dehydratase

CDS_05205: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

CDS_05206: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.75	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0002635.2	0.52	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0001201.3	0.52	terpene	eremophilene	Sorangium cellulosum So ce56
BGC0000541.5	0.48	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000544.4	0.48	ribosomal	planosporicin	Planomonospora alba
BGC0001289.5	0.47	ribosomal	penisin	Paenibacillus ehimensis
BGC0002031.3	0.46	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0000902.4	0.45	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000529.5	0.45	ribosomal	microbisporicin A2	Microbispora corallina
BGC0000542.3	0.44	ribosomal	paenicidin B	Paenibacillus terrae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.75	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0002635.2	0.52	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0001201.3	0.52	terpene	eremophilene	Sorangium cellulosum So ce56
BGC0000541.5	0.48	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000544.4	0.48	ribosomal	planosporicin	Planomonospora alba
BGC0001289.5	0.47	ribosomal	penisin	Paenibacillus ehimensis
BGC0002031.3	0.46	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0000902.4	0.45	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000529.5	0.45	ribosomal	microbisporicin A2	Microbispora corallina
BGC0000542.3	0.44	ribosomal	paenicidin B	Paenibacillus terrae

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for CDS_05205

CDS_05204

Leader:

MNDKILLEETTETRDFADLDLDVRIAEGEVGAA

Core:

DFNAAAPYTVSPNTWGVQSRCWTCCR

Core with dehydrations:

DFNAAAPYDhbVDhaPNDhbWGVQDhaRCysWDhbCysCysR

antiSMASH-DB 4.0 matches for CDS_05204

63.0%

NZ_BIFH01000040.1:

Lanthipeptides: EMA17_RS40630_lanthipeptide

1

DFNAA-APYTVSPNTWGVQSRCWTCC

25

DF A+ A T+SP+T GVQSRCW CC

1

DFGASGASVTLSPSTRGVQSRCWVCC

26

34.6%

NZ_KB891308.1and 2 others:

NZ_KZ819159.1 Lanthipeptides: DBP19_RS30055_lanthipeptideNZ_RCOL01000001.1 Lanthipeptides: STAN_RS32200_lanthipeptide

Lanthipeptides: B061_RS37915_lanthipeptide

4

AAAPYTVSPNTWGVQSRCWTCC

25

A YT SP+++ + +RC CC

3

GAGTYT-SPSSYAIGTRCPVCC

23

26.9%

NZ_NNBP01000006.1:

Lanthipeptides: CG747_RS11965_lanthipeptide

11

SPNTWGVQSRCWTCC

25

SP+++ + +RC TCC

2

SPSSYAIGTRCPTCC

16

with 7 more sequence matches

25.0%

NZ_CP067113.1:

Lanthipeptides: JGR68_RS08310_lanthipeptide

1

DFNAAAPYTVSPNTWGVQSRCWT

23

D +AAA T+S N GV + W+

3

DVDAAAWSTMSRNCGGVGASEWS

25

24.2%

NZ_CP084204.1:

Lanthipeptides: LDH80_RS14690_lanthipeptide

9

TVSPN-TWGVQSRCWTCC

25

T++P TW + C TCC

16

TITPTMTWSELAMCGTCC

33

23.1%

NZ_AP025344.1:

Lanthipeptides: L6439_RS11925_lanthipeptide

5

AAPYTVSPNTWGVQSR

20

A P +P W QS+

1

ATPILTTPTRWSTQSQ

16

23.1%

NZ_BEWD01000004.1and 19 others:

NZ_BMUN01000001.1 Lanthipeptides: IE238_RS00870_lanthipeptideNZ_BMVQ01000001.1 Lanthipeptides: IE283_RS00890_lanthipeptideNZ_BMWI01000001.1 Lanthipeptides: IE253_RS05465_lanthipeptideNZ_CP012382.1 Lanthipeptides: SAM23877_RS36835_lanthipeptideNZ_CP012949.1 Lanthipeptides: SAM40697_RS33360_lanthipeptideNZ_CP027299.1 Lanthipeptides: C1N79_RS34825_lanthipeptideNZ_CP039123.1 Lanthipeptides: E5N77_RS35110_lanthipeptideNZ_CP042324.1 Lanthipeptides: FQ762_RS01285_lanthipeptideNZ_CP054939.1 Lanthipeptides: HUT14_RS33610_lanthipeptideNZ_CP104697.1 Lanthipeptides: N6Q81_RS33410_lanthipeptideNZ_CP104697.1 Lanthipeptides: N6Q81_RS33410_lanthipeptideNZ_FKJH01000076.1 Lanthipeptides: STEPF7_RS31605_lanthipeptideNZ_GG657756.1 Lanthipeptides: SSPG_RS36720_lanthipeptideNZ_GG657758.1 Lanthipeptides: SSRG_RS36710_lanthipeptideNZ_JACWAA010000001.1 Lanthipeptides: ICA23_RS00945_lanthipeptideNZ_KK853997.1 Lanthipeptides: KCH_RS38645_lanthipeptideNZ_KZ195574.1 Lanthipeptides: B9W62_RS39030_lanthipeptideNZ_LT629768.1 Lanthipeptides: BLU60_RS01655_lanthipeptideNZ_MQUH01000030.1 Lanthipeptides: BSZ07_RS37165_lanthipeptide

Lanthipeptides: Sru02f_RS16280_lanthipeptide

11

SPNTWGVQSRCWTCC

25

SP+++ + +RC CC

10

SPSSYAIGTRCPICC

24

23.1%

NZ_CP043959.1and 9 others:

NZ_CP058273.1 Lanthipeptides: AY578_RS00390_lanthipeptideNZ_CP104864.1 Lanthipeptides: N7E53_RS01070_lanthipeptideNZ_CP113837.1 Lanthipeptides: OU787_RS28205_lanthipeptideNZ_JMLN01000003.1 Lanthipeptides: BR33_RS35695_lanthipeptideNZ_KL503830.1 Lanthipeptides: DJ64_RS34550_lanthipeptideNZ_LISX01000001.1 Lanthipeptides: AMK19_RS02530_lanthipeptideNZ_NNBO01000011.1 Lanthipeptides: CG736_RS24265_lanthipeptideNZ_VIUV01000001.1 Lanthipeptides: FB570_RS00565_lanthipeptideNZ_WUUF01000042.1 Lanthipeptides: GSE51_RS09870_lanthipeptide

Lanthipeptides: F3L20_RS18420_lanthipeptide

11

SPNTWGVQSRCWTCC

25

SP+++ + +RC CC

10

SPSSYAIGTRCPVCC

24

22.9%

NZ_FPCC01000026.1:

Lanthipeptides: BM377_RS12940_lanthipeptide

3

NAAAPYTVSPNTWGVQSRC

21

NAA T SP + RC

17

NAAMAITASPVLITLDGRC

35

18.6%

NZ_CP017169.1and 4 others:

NZ_CP017170.1 Lanthipeptides: allorf_7976356_7976523_lanthipeptideNZ_CP017172.1 Lanthipeptides: allorf_8132949_8133116_lanthipeptideNZ_CP017173.1 Lanthipeptides: allorf_8007609_8007776_lanthipeptideNZ_CP113950.1 Lanthipeptides: allorf_8179799_8179966_lanthipeptide

Lanthipeptides: allorf_8050142_8050309_lanthipeptide

3

NAAAPYTVSPNTWGVQSRCW

22

++ AP PN V SR W

4

SSRAPRLFRPNPARVSSRPW

23

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (8):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.19 out of 29.38

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.54 out of 23.43

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.63 out of 23.43

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.62 out of 32.74

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 17.88 out of 25.88

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.20 out of 20.97

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.02 out of 24.78

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

CDS_05204 - Class I

Cleavage pHMM score: -6.20

RODEO score: 18

Monoisotopic mass: 2858.3 Da

Molecular weight: 2860.1 Da

Number of bridges: 3

Additional modifications: OH

Alternative weights: (assuming N unmodified Ser/Thr residues); 2878.2 Da N = 1; 2896.2 Da N = 2

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 184 - 267; Score: 50.8

TFBS definitions

Regulator	Description

NPDC021375.ctg-0010 - Region 4 - NRPS

Download region GenBank file

Download region SVG

Location: 195,172 - 248,821 nt. (total: 53,650 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CDS_05250: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Transferases: acyltransferase

CDS_05252: polyketide synthase associated protein papA3

smcogs: SMCOG1209: polyketide synthase associated protein papA3

Lyases: decarboxylase

CDS_05238: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Ligases: ligase

CDS_05251: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_05253: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_05254: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CDS_05257: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Translocases: permease

CDS_05240: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

CDS_05247: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.75	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.69	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001250.4	0.68	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.68	NRPS	epichloenin A	Epichloe festucae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.75	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.69	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001250.4	0.68	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.68	NRPS	epichloenin A	Epichloe festucae

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.80 out of 20.47

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.34 out of 20.97

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.91 out of 27.04

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.62 out of 27.04

Confidence: medium

Additional weak hits (18):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.24 out of 27.55

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 12.96 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 12.97 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.45 out of 26.06

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.02 out of 30.97

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 16.79 out of 30.97

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.13 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.44 out of 31.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.18 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.11 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.81 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.40 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.17 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.98 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.51 out of 26.06

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.99 out of 28.19

Confidence: weak

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 17.99 out of 25.31

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 5, location 195171 - 248821:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Ser) + (Gly)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_05251: X

AMP-binding (525..922): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DTEDIGSIIK
Nearest Stachelhaus code(s):: Lys DTEDIGSVIK (74% 8Å match)
Stachelhaus code match:: 90% (moderate)

CDS_05252: Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (503..899): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHVSLVDK
Nearest Stachelhaus code(s):: Ser DVWHVSLVDK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

CDS_05253: X

AMP-binding (28..410): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: NATFGTYPAK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

CDS_05254: Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (481..875): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DIVQIGVVWK
Nearest Stachelhaus code(s):: Gly DILQLGVVWK (76% 8Å match)
Stachelhaus code match:: 80% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
DasR	N-acetylglucosamine dependent repressor
RpoN	Regulator of nitrogen assimilation and virulence
VqsM	Regulator of quorum-sensing signalling systems

NPDC021375.ctg-0010 - Region 5 - terpene

Download region GenBank file

Download region SVG

Location: 390,115 - 405,638 nt. (total: 15,524 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: kinase

CDS_05413: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Lyases: cyclase

CDS_05420: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001364.3	0.37	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0000874.5	0.32	other (other)	blasticidin S	Streptomyces griseochromogenes
BGC0002657.2	0.31	NRPS, PKS	deoxyhangtaimycin	Streptomyces spectabilis
BGC0002340.3	0.28	NRPS, other (other)	pyrroloformamide A, pyrroloformamide B, pyrroloformamide D, pyrroloformamide C	Streptomyces sp. CB02980
BGC0001484.3	0.27	other (other)	2'-chloropentostatin, 2'-amino-2'-deoxyadenosine	Actinomadura sp. ATCC 39365
BGC0001200.4	0.27	PKS	lorneic acid A	Streptomyces sp. NBRC 109706
BGC0001491.3	0.25	PKS	67-121C	Couchioplanes caeruleus subsp. caeruleus
BGC0001812.3	0.24	PKS	tylactone	Micromonospora chalcea subsp. izumensis
BGC0000439.5	0.23	NRPS	taromycin A	Saccharomonospora sp. CNQ490
BGC0001503.4	0.21	PKS	amycolamycin A, amycolamycin B	Amycolatopsis sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001364.3	0.37	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0000874.5	0.32	other (other)	blasticidin S	Streptomyces griseochromogenes
BGC0002657.2	0.31	NRPS, PKS	deoxyhangtaimycin	Streptomyces spectabilis
BGC0002340.3	0.28	NRPS, other (other)	pyrroloformamide A, pyrroloformamide B, pyrroloformamide D, pyrroloformamide C	Streptomyces sp. CB02980
BGC0001484.3	0.27	other (other)	2'-chloropentostatin, 2'-amino-2'-deoxyadenosine	Actinomadura sp. ATCC 39365
BGC0001200.4	0.27	PKS	lorneic acid A	Streptomyces sp. NBRC 109706
BGC0001491.3	0.25	PKS	67-121C	Couchioplanes caeruleus subsp. caeruleus
BGC0001812.3	0.24	PKS	tylactone	Micromonospora chalcea subsp. izumensis
BGC0000439.5	0.23	NRPS	taromycin A	Saccharomonospora sp. CNQ490
BGC0001503.4	0.21	PKS	amycolamycin A, amycolamycin B	Amycolatopsis sp.

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

No product predictions

Genes with terpene domains:

CDS_05420: T1TS

Domain 1 (10 - 317): Type 1 terpene synthase

Subtype: unknown

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.11 out of 19.52

Confidence: medium

Additional weak hits (2):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.69 out of 20.97

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.86 out of 19.52

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production

NPDC021375.ctg-0011 - Region 1 - T3PKS

Download region GenBank file

Download region SVG

Location: 15,915 - 57,024 nt. (total: 41,110 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase glycosyltransferase methyltransferase transferase

CDS_05457: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

CDS_05459: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

CDS_05467: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

CDS_05468: methyltransferase

smcogs: SMCOG1089: methyltransferase

CDS_05471: methyltransferase

smcogs: SMCOG1089: methyltransferase

Ligases: synthase

CDS_05461: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002127.3	0.60	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0000902.4	0.59	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0001310.5	0.59	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0000285.5	0.56	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0000280.5	0.48	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0000281.3	0.47	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0000652.5	0.44	terpene	napyradiomycin	Streptomyces sp. CNQ525
BGC0000261.5	0.43	PKS	R1128	Streptomyces sp. R1128
BGC0001079.5	0.43	PKS, terpene	napyradiomycin A80915C, napyradiomycin 2, napyradiomycin 3, napyradiomycin 4	Streptomyces aculeolatus
BGC0001078.5	0.43	PKS, terpene	furaquinocin B	Streptomyces sp. KO-3988

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002127.3	0.60	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0000902.4	0.59	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0001310.5	0.59	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0000285.5	0.56	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0000280.5	0.48	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0000281.3	0.47	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0000652.5	0.44	terpene	napyradiomycin	Streptomyces sp. CNQ525
BGC0000261.5	0.43	PKS	R1128	Streptomyces sp. R1128
BGC0001079.5	0.43	PKS, terpene	napyradiomycin A80915C, napyradiomycin 2, napyradiomycin 3, napyradiomycin 4	Streptomyces aculeolatus
BGC0001078.5	0.43	PKS, terpene	furaquinocin B	Streptomyces sp. KO-3988

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 24.19 out of 27.04

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

Additional weak hits (8):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.56 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.10 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.68 out of 27.78

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.21 out of 36.54

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.61 out of 27.78

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.18 out of 32.93

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.34 out of 29.65

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
DasR	N-acetylglucosamine dependent repressor

NPDC021375.ctg-0011 - Region 2 - lanthipeptide-class-iii

Download region GenBank file

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Location: 107,438 - 130,035 nt. (total: 22,598 nt) Show pHMM detection rules used

lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000551.5	0.81	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000496.5	0.69	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000513.3	0.61	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000501.3	0.61	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000519.4	0.60	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000553.3	0.57	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000518.3	0.53	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000546.3	0.50	ribosomal	SAL-2242	Streptomyces albidoflavus
BGC0002700.2	0.49	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0002111.3	0.46	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000551.5	0.81	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000496.5	0.69	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000513.3	0.61	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000501.3	0.61	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000519.4	0.60	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000553.3	0.57	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000518.3	0.53	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000546.3	0.50	ribosomal	SAL-2242	Streptomyces albidoflavus
BGC0002700.2	0.49	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0002111.3	0.46	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for CDS_05533

CDS_05534

Leader:

MALLDLQALETDEAPEFGGGG

Core:

GGGSRASLLLCGNSSLSLVTCN

Core with dehydrations:

GGGDhaRADhaLLLCysGNDhaDhaLDhaLVDhbCysN

antiSMASH-DB 4.0 matches for CDS_05534

86.4%

NZ_CP048835.1:

Lanthipeptides: C8250_RS00390_lanthipeptide

2

GGSRASLLLCGNSSLSLVTCN

22

GGSRASLLLCGNSSLS+ TCN

1

GGSRASLLLCGNSSLSVTTCN

21

83.3%

NZ_JACHJG010000001.1:

Lanthipeptides: FHS38_RS02665_lanthipeptide

1

GGGSRASLLLCGNSSLSLVTCN

22

GGGSRASLLLCG+SSLS+VTCN

3

GGGSRASLLLCGDSSLSVVTCN

24

82.6%

NZ_CP102509.1:

Lanthipeptides: JIW86_RS37035_lanthipeptide

1

GGGSRASLLLCGNSSLSLVTCN

22

GGGSRASLLLCG+SSLSL TC+

2

GGGSRASLLLCGDSSLSLTTCH

23

with 107 more sequence matches

Only the first 10 are displayed here.

81.8%

NZ_JAGGOI010000031.1:

Lanthipeptides: J7E87_RS22160_lanthipeptide

2

GGSRASLLLCGNSSLSLVTCN

22

GGSRASLLLCG+SSLS+ TCN

1

GGSRASLLLCGDSSLSVTTCN

21

79.2%

NZ_BMVE01000003.1and 16 others:

NZ_BMVL01000005.1 Lanthipeptides: IE257_RS16230_lanthipeptideNZ_CP011664.1 Lanthipeptides: M444_RS30240_lanthipeptideNZ_CP020039.1 Lanthipeptides: B4U39_RS34445_lanthipeptideNZ_CP020555.1 Lanthipeptides: B6R96_RS03515_lanthipeptideNZ_CP023701.1 Lanthipeptides: CP968_RS29065_lanthipeptideNZ_CP029189.1 Lanthipeptides: DEJ51_RS31910_lanthipeptideNZ_CP033581.1 Lanthipeptides: EES41_RS31595_lanthipeptideNZ_CP034350.1 Lanthipeptides: D1J60_RS32970_lanthipeptideNZ_CP043638.1 Lanthipeptides: F1D59_RS34930_lanthipeptideNZ_CP115936.1 Lanthipeptides: PET44_RS28650_lanthipeptideNZ_CP116355.1 Lanthipeptides: KPP03845_RS32700_lanthipeptideNZ_JAFLQY010000003.1 Lanthipeptides: J0X20_RS29030_lanthipeptideNZ_LIVP01000027.1 Lanthipeptides: AMK15_RS28680_lanthipeptideNZ_LWLD01000038.1 Lanthipeptides: A6A28_RS28600_lanthipeptideNZ_ML123038.1 Lanthipeptides: EES37_RS30340_lanthipeptideNZ_NNBM01000002.1 Lanthipeptides: CG724_RS07855_lanthipeptide

Lanthipeptides: IE248_RS10435_lanthipeptide

1

GGGSRASLLLCGNSSLSLVTCN

22

GGGSRASLLLCG+SSLS+ TCN

3

GGGSRASLLLCGDSSLSITTCN

24

77.3%

NC_018750.1and 77 others:

NC_018750.1 Lanthipeptides: SVEN_RS32110_lanthipeptideNZ_BBNO01000003.1 Lanthipeptides: TU31_RS37940_lanthipeptideNZ_BMSV01000002.1 Lanthipeptides: IE106_RS06150_lanthipeptideNZ_BMTO01000007.1 Lanthipeptides: IE136_RS15615_lanthipeptideNZ_BMTP01000009.1 Lanthipeptides: IE109_RS18470_lanthipeptideNZ_BMTU01000009.1 Lanthipeptides: IE118_RS22890_lanthipeptideNZ_BMUN01000001.1 Lanthipeptides: IE238_RS00740_lanthipeptideNZ_CP007699.2 Lanthipeptides: T261_RS39185_lanthipeptideNZ_CP009754.1 Lanthipeptides: NI25_RS05015_lanthipeptideNZ_CP015866.1 Lanthipeptides: Spa2297_RS27800_lanthipeptideNZ_CP017157.1 Lanthipeptides: SL103_RS15895_lanthipeptideNZ_CP019457.1 Lanthipeptides: BXT88_RS03410_lanthipeptideNZ_CP019724.1 Lanthipeptides: B1H29_RS35355_lanthipeptideNZ_CP019779.1 Lanthipeptides: STRMOE7_RS03775_lanthipeptideNZ_CP023691.1 Lanthipeptides: CP981_RS03050_lanthipeptideNZ_CP023700.1 Lanthipeptides: CP969_RS04700_lanthipeptideNZ_CP027299.1 Lanthipeptides: C1N79_RS34970_lanthipeptideNZ_CP029042.1 Lanthipeptides: DDE74_RS03525_lanthipeptideNZ_CP029195.1 Lanthipeptides: DEJ45_RS04995_lanthipeptideNZ_CP029195.1 Lanthipeptides: DEJ45_RS04995_lanthipeptideNZ_CP029196.1 Lanthipeptides: DEJ44_RS30395_lanthipeptideNZ_CP029196.1 Lanthipeptides: DEJ44_RS30395_lanthipeptideNZ_CP029541.1 Lanthipeptides: DKG71_RS05245_lanthipeptideNZ_CP034279.1 Lanthipeptides: EIZ62_RS28660_lanthipeptideNZ_CP034353.1 Lanthipeptides: D1J63_RS04900_lanthipeptideNZ_CP039123.1 Lanthipeptides: E5N77_RS35250_lanthipeptideNZ_CP043317.1 Lanthipeptides: FYC74_RS09720_lanthipeptideNZ_CP046905.1 Lanthipeptides: GPZ77_RS32930_lanthipeptideNZ_CP047140.1 Lanthipeptides: GLX30_RS11420_lanthipeptideNZ_CP050976.1 Lanthipeptides: HEP86_RS04470_lanthipeptideNZ_CP054920.1 Lanthipeptides: HUT15_RS04615_lanthipeptideNZ_CP060825.1 Lanthipeptides: IAG43_RS32355_lanthipeptideNZ_CP074111.1 Lanthipeptides: KE639_RS31630_lanthipeptideNZ_CP084681.1 Lanthipeptides: KI385_RS00885_lanthipeptideNZ_CP085300.1 Lanthipeptides: LJA35_RS05220_lanthipeptideNZ_CP086217.1 Lanthipeptides: LJ741_RS03435_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS09690_lanthipeptideNZ_CP098437.1 Lanthipeptides: NCG97_RS34740_lanthipeptideNZ_CP099468.1 Lanthipeptides: NFX46_RS16770_lanthipeptideNZ_CP101137.1 Lanthipeptides: M6G08_RS24535_lanthipeptideNZ_CP102332.1 Lanthipeptides: NRO40_RS01140_lanthipeptideNZ_CP102609.1 Lanthipeptides: NUT86_RS03980_lanthipeptideNZ_CP104697.1 Lanthipeptides: N6Q81_RS33560_lanthipeptideNZ_CP114202.1 Lanthipeptides: STRLI_RS35870_lanthipeptideNZ_CP114203.1 Lanthipeptides: STRNI_RS37360_lanthipeptideNZ_CP114205.1 Lanthipeptides: STRTU_RS33380_lanthipeptideNZ_JACHJE010000006.1 Lanthipeptides: FHS32_RS15850_lanthipeptideNZ_JACHJI010000005.1 Lanthipeptides: FHS37_RS15430_lanthipeptideNZ_JACSCH020000032.1 Lanthipeptides: E0F75_RS38565_lanthipeptideNZ_JACSCH020000032.1 Lanthipeptides: E0F75_RS38565_lanthipeptideNZ_JACSCH020000032.1 Lanthipeptides: E0F75_RS38565_lanthipeptideNZ_JACWAA010000001.1 Lanthipeptides: ICA23_RS00800_lanthipeptideNZ_JADMLH010000003.1 Lanthipeptides: IT780_RS09875_lanthipeptideNZ_JAFEJA010000002.1 Lanthipeptides: JE024_RS34830_lanthipeptideNZ_JAGPYC010000033.1 Lanthipeptides: KBZ00_RS31440_lanthipeptideNZ_JAHLXF010000022.1 Lanthipeptides: KQY13_RS30555_lanthipeptideNZ_JAIHBQ010000001.1 Lanthipeptides: K4902_RS04515_lanthipeptideNZ_JAJJMU010000026.1 Lanthipeptides: LOC25_RS31275_lanthipeptideNZ_JAJNOJ010000002.1 Lanthipeptides: MBT42_RS06255_lanthipeptideNZ_JAJNOJ010000002.1 Lanthipeptides: MBT42_RS06255_lanthipeptideNZ_JAMGSL010000004.1 Lanthipeptides: M5362_RS09920_lanthipeptideNZ_JAMGSL010000004.1 Lanthipeptides: M5362_RS09920_lanthipeptideNZ_JAPKNL010000004.1 Lanthipeptides: OSI21_RS07750_lanthipeptideNZ_JH993790.1 Lanthipeptides: STRVIR_RS0131905_lanthipeptideNZ_KN039948.1 Lanthipeptides: FM21_RS29525_lanthipeptideNZ_LIPF01000004.1 Lanthipeptides: AMK11_RS16660_lanthipeptideNZ_LIVV01000002.1 Lanthipeptides: AMK27_RS08700_lanthipeptideNZ_LIVV01000002.1 Lanthipeptides: AMK27_RS08700_lanthipeptideNZ_LIVX01000004.1 Lanthipeptides: AMK29_RS15650_lanthipeptideNZ_LIWB01000010.1 Lanthipeptides: AMK33_RS24360_lanthipeptideNZ_LIYH01000004.1 Lanthipeptides: AMK26_RS17765_lanthipeptideNZ_MPOH02000012.1 Lanthipeptides: BM536_RS17150_lanthipeptideNZ_NBCN01000003.1 Lanthipeptides: BKD26_RS06570_lanthipeptideNZ_NNBP01000011.1 Lanthipeptides: CG747_RS19290_lanthipeptideNZ_NNBP01000011.1 Lanthipeptides: CG747_RS19290_lanthipeptideNZ_RAIF01000032.1 Lanthipeptides: EBH09_RS35480_lanthipeptideNZ_SOPG01000008.1 Lanthipeptides: E0I08_RS17090_lanthipeptide

Lanthipeptides: SVEN_RS32110_lanthipeptide

3

GSRASLLLCGNSSLSLVTCN

22

GSRASLLLCG+SSLS+ TCN

2

GSRASLLLCGDSSLSVTTCN

21

77.3%

NZ_BBOK01000011.1and 28 others:

NZ_BEWD01000001.1 Lanthipeptides: Sru02f_RS01660_lanthipeptideNZ_BMSL01000016.1 Lanthipeptides: IE215_RS23330_lanthipeptideNZ_BMUC01000023.1 Lanthipeptides: IE172_RS32210_lanthipeptideNZ_BMVQ01000005.1 Lanthipeptides: IE283_RS17035_lanthipeptideNZ_BMWI01000025.1 Lanthipeptides: IE253_RS33945_lanthipeptideNZ_CM002280.1 Lanthipeptides: M877_RS44575_lanthipeptideNZ_CP012382.1 Lanthipeptides: SAM23877_RS30085_lanthipeptideNZ_CP012949.1 Lanthipeptides: SAM40697_RS29010_lanthipeptideNZ_CP018047.1 Lanthipeptides: BBN63_RS03065_lanthipeptideNZ_CP042324.1 Lanthipeptides: FQ762_RS34495_lanthipeptideNZ_CP043959.1 Lanthipeptides: F3L20_RS19105_lanthipeptideNZ_CP045547.1 Lanthipeptides: GEV49_RS05730_lanthipeptideNZ_CP048397.1 Lanthipeptides: SSPS47_RS31455_lanthipeptideNZ_CP054939.1 Lanthipeptides: HUT14_RS29815_lanthipeptideNZ_CP094918.1 Lanthipeptides: MTR79_RS16715_lanthipeptideNZ_GG657756.1 Lanthipeptides: SSPG_RS05020_lanthipeptideNZ_GG657758.1 Lanthipeptides: SSRG_RS03855_lanthipeptideNZ_JAAIFS010000001.1 Lanthipeptides: GUR47_RS02255_lanthipeptideNZ_JACHEM010000005.1 Lanthipeptides: HNQ79_RS11445_lanthipeptideNZ_KZ195574.1 Lanthipeptides: B9W62_RS05695_lanthipeptideNZ_LT629768.1 Lanthipeptides: BLU60_RS34110_lanthipeptideNZ_MQUH01000025.1 Lanthipeptides: BSZ07_RS33280_lanthipeptideNZ_RAII01000001.1 Lanthipeptides: EBH12_RS10360_lanthipeptideNZ_RSEG01000006.1 Lanthipeptides: EIA57_RS12710_lanthipeptideNZ_SOAV01000001.1 Lanthipeptides: EV562_RS04520_lanthipeptideNZ_VIUV01000020.1 Lanthipeptides: FB570_RS34060_lanthipeptideNZ_WHZR01000001.1 Lanthipeptides: STPH1_RS04005_lanthipeptideNZ_WXVT01000001.1 Lanthipeptides: STPH2_RS03995_lanthipeptide

Lanthipeptides: APK71_RS25550_lanthipeptide

3

GSRASLLLCGNSSLSLVTCN

22

GSRASLLLCG+SSLS+ TCN

2

GSRASLLLCGDSSLSITTCN

21

77.3%

NZ_BIFH01000016.1:

Lanthipeptides: EMA17_RS12985_lanthipeptide

1

GGGSRASLLLCGNSSLSLVTCN

22

GGGS SLLLCGNSSLSL+ C+

1

GGGSNVSLLLCGNSSLSLLQCH

22

77.3%

NZ_BNCA01000002.1and 1 other:

NZ_CP049782.1 Lanthipeptides: G7Z12_RS34445_lanthipeptide

Lanthipeptides: IE314_RS02760_lanthipeptide

3

GSRASLLLCGNSSLSLVTCN

22

GSRASLLLCG+SSLS+ TCN

2

GSRASLLLCGDSSLSVSTCN

21

77.3%

NZ_CP036455.1:

Lanthipeptides: EKD16_RS17975_lanthipeptide

2

GGSRASLLLCGNSSLSLVTCN

22

GS ASLLLCG+SSLSL TCN

1

AGSEASLLLCGDSSLSLTTCN

21

77.3%

NZ_CP077658.1:

Lanthipeptides: KQY30_RS33045_lanthipeptide

3

GSRASLLLCGNSSLSLVTCN

22

SRASLLLCG+SSLS+VTCN

1

ASRASLLLCGDSSLSVVTCN

20

77.3%

NZ_QGGR01000008.1:

Lanthipeptides: BC793_RS19230_lanthipeptide

2

GGSRASLLLCGNSSLSLVTCN

22

GGS+ASLLLCG+SSLS+ TCN

1

GGSQASLLLCGDSSLSVTTCN

21

72.7%

NZ_FOET01000001.1and 2 others:

NZ_FOSG01000005.1 Lanthipeptides: BM237_RS08435_lanthipeptideNZ_PDKQ02000044.1 Lanthipeptides: BFM75_RS16855_lanthipeptide

Lanthipeptides: BMY40_RS02540_lanthipeptide

2

GGSRASLLLCGNSSLSLVTCN

22

GGS ASLLLCG+SSLS+ TC

1

GGSEASLLLCGDSSLSVTTCR

21

MIBiG 4.0 matches for CDS_05534

54.5%

BGC0000553.3 (SSGG_RS09925):

Lanthipeptide: SRO15-2212

3

GSRASLLLCGNSSLSLVTCN

22

GS+ SLL+C SSLS+V C

2

GSQVSLLVCEYSSLSVVLCT

21

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.11 out of 19.52

Confidence: medium

Additional weak hits (12):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.82 out of 26.12

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.34 out of 21.55

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.38 out of 26.06

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.03 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.84 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.23 out of 29.38

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 16.57 out of 30.97

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.86 out of 35.63

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.06 out of 25.88

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.55 out of 26.85

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.07 out of 33.14

Confidence: weak

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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Lanthipeptides

TFBS Finder

Core peptide predictions

CDS_05534 - Class III

Cleavage pHMM score: 8.10

RODEO score: 0

Monoisotopic mass: 2000.0 Da

Molecular weight: 2001.3 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2019.3 Da N = 1; 2037.3 Da N = 2; 2055.3 Da N = 3; 2073.3 Da N = 4

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production

NPDC021375.ctg-0011 - Region 3 - NRPS,NRPS-like

Download region GenBank file

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Location: 182,272 - 249,526 nt. (total: 67,255 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase synthase

CDS_05603: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CDS_05613: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

CDS_05616: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

CDS_05617: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

CDS_05620: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

CDS_05621: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

Transferases: acyltransferase aminotransferase halogenase methyltransferase

CDS_05606: polyketide synthase associated protein papA3

smcogs: SMCOG1209: polyketide synthase associated protein papA3

CDS_05612: flavin-dependent trp 6 7 halogenase

halogenases: flavin-dependent trp 6 7 halogenase
MITE: MITE0000030Halogenation (identity: 76.70%)
smcogs: SMCOG1119: halogenase

CDS_05615: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

CDS_05627: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: esterase synthase

CDS_05604: thioesterase

smcogs: SMCOG1004: thioesterase

CDS_05621: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

Ligases: ligase

CDS_05602: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_05605: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.83	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	0.81	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	0.79	NRPS	AM-toxin	Alternaria alternata
BGC0001128.4	0.78	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.78	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.77	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002075.3	0.75	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001135.5	0.74	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.75	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002075.3	0.75	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000426.5	0.74	NRPS	sevadicin	Paenibacillus larvae
BGC0001825.4	0.73	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.73	NRPS	AM-toxin	Alternaria alternata
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.72	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 25.48 out of 27.04

Confidence: strong

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 22.41 out of 27.04

Confidence: medium

Additional weak hits (11):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.26 out of 32.74

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.44 out of 26.12

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.09 out of 27.78

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.41 out of 25.75

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.91 out of 27.78

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.79 out of 30.25

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 24.93 out of 30.98

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.10 out of 35.63

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 20.14 out of 33.14

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.67 out of 24.78

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 3, location 182271 - 249526:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Thr) + (D-Val - Leu) + (D-Leu - Ser - Trp)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 182271 - 225076:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Thr) + (D-Val - Leu) + (D-Leu - Ser - Trp)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 186961 - 249526:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Thr) + (D-Val - Leu) + (D-Leu - Ser - Trp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_05602: Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (329..730): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

CDS_05605: Val - Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (62..460): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAYFWGVVFK
Nearest Stachelhaus code(s):: Ile DAYFWGVTFK (85% 8Å match); Leu DAYFWGVTFK (82% 8Å match); Ile or Val DAYFWGVTFK (79% 8Å match); Val DAYFWGVTFK (79% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1630..2022): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVFSVAAYAK
Nearest Stachelhaus code(s):: Leu DVFSVAAYAK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

CDS_05606: Leu - Ser - Trp

Search NORINE for peptide: strict or relaxed

AMP-binding (469..857): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVFSVAAYAK
Nearest Stachelhaus code(s):: Leu DVFSVAAYAK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2012..2405): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHVSLVDK
Nearest Stachelhaus code(s):: Ser DVWHVSLVDK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4491..4882): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVCMVGVACK
Nearest Stachelhaus code(s):: Trp DVCMVGVVCK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
DasR	N-acetylglucosamine dependent repressor

NPDC021375.ctg-0011 - Region 4 - NRPS

Download region GenBank file

Download region SVG

Location: 300,072 - 350,561 nt. (total: 50,490 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

CDS_05670: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: esterase hydrolase

CDS_05675: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

CDS_05679: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

CDS_05683: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase

CDS_05684: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	0.72	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.71	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.71	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001135.5	0.69	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	0.72	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.71	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.71	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001135.5	0.69	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.16 out of 23.79

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.64 out of 26.33

Confidence: medium

Additional weak hits (11):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.11 out of 26.33

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.05 out of 20.97

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.70 out of 20.97

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.41 out of 29.51

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.48 out of 29.25

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.82 out of 28.14

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.65 out of 21.55

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.37 out of 24.78

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.13 out of 35.63

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.12 out of 29.65

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.82 out of 28.14

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 6, location 300071 - 350561:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ala - Gly) + (Asp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_05683: Asp

Search NORINE for peptide: strict or relaxed

AMP-binding (505..909): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIAHVSK
Nearest Stachelhaus code(s):: Asp DLTKIGHVGK (71% 8Å match)
Stachelhaus code match:: 80% (moderate)

CDS_05684: Ala - Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (23..402): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DIYNNVLVYK
Nearest Stachelhaus code(s):: Gly DLYNNCLVYK (82% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1058..1454): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGMVWK
Nearest Stachelhaus code(s):: Gly DILQLGMVWK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
IolR	Regulator of the inositol catabolism

NPDC021375.ctg-0013 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 92,405 - 146,085 nt. (total: 53,681 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carbamoyltransferase methyltransferase

CDS_06203: ornithine carbamoyltransferase

smcogs: SMCOG1114: ornithine carbamoyltransferase

CDS_06214: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: dehalogenase esterase

CDS_06219: putative esterase

smcogs: SMCOG1104: putative esterase

CDS_06223: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Ligases: ligase synthase

CDS_06195: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_06202: carboxylate-amine ligase

smcogs: SMCOG1165: carboxylate-amine ligase

CDS_06207: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CDS_06208: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

CDS_06209: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001261.3	0.72	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.69	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001261.3	0.72	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.69	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.39 out of 25.31

Confidence: medium

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 20.99 out of 23.43

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.35 out of 18.57

Confidence: medium

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 24.49 out of 30.22

Confidence: medium

Additional weak hits (17):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.74 out of 31.73

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.38 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.69 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.36 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.85 out of 26.06

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.59 out of 20.97

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.69 out of 30.97

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 25.83 out of 30.98

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 22.24 out of 32.38

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.52 out of 29.65

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.31 out of 25.88

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.95 out of 23.43

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.89 out of 29.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.68 out of 31.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.67 out of 29.38

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.22 out of 30.98

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.96 out of 29.65

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 92404 - 146085:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Arg - Ser) + (Arg)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_06195: X

AMP-binding (104..543): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: -MNGGTTTGK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

CDS_06207: Arg

Search NORINE for peptide: strict or relaxed

AMP-binding (484..898): Arg

nrpys: Arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVENVGGITK
Nearest Stachelhaus code(s):: Arg DVENVGGITK (76% 8Å match)
Stachelhaus code match:: 100% (strong)

CDS_06209: Arg - Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (20..437): Arg

nrpys: Arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVENVGAITK
Nearest Stachelhaus code(s):: Arg DVENVGAITK (74% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1110..1526): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHISLVDK
Nearest Stachelhaus code(s):: Ser DVWHISLVDK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
BldD	Development and antibiotic global regulator
CatR	H2O2-responsive repressor
ClgR	Caseinolytic protease gene regulator
ToxT	Regulator of MSHA biosynthesis

NPDC021375.ctg-0013 - Region 2 - NRPS,NRPS-like

Download region GenBank file

Download region SVG

Location: 275,695 - 337,741 nt. (total: 62,047 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase reductase

CDS_06364: Dioxygenase TauD/TfdA

smcogs: SMCOG1046: Dioxygenase TauD/TfdA

CDS_06381: Halogenation

MITE: MITE0000005Halogenation (identity: 60.00%)
smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

CDS_06382: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

CDS_06386: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Transferases: reductase

CDS_06381: Halogenation

MITE: MITE0000005Halogenation (identity: 60.00%)
smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Hydrolases: dehalogenase esterase

CDS_06369: thioesterase

smcogs: SMCOG1004: thioesterase

CDS_06391: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Ligases: ligase synthase

CDS_06357: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

CDS_06361: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_06365: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CDS_06366: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_06367: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_06370: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_06373: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	1.25	NRPS	dimethylcoprogen	Alternaria alternata
BGC0000342.4	1.20	NRPS	enniatin	Fusarium equiseti
BGC0001132.4	1.11	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	1.09	NRPS	AM-toxin	Alternaria alternata
BGC0001128.4	1.09	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	1.09	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	1.06	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002164.2	1.02	NRPS	peramine	Epichloe festucae
BGC0002135.2	1.02	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	1.02	NRPS	AbT1	Aureobasidium pullulans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000342.4	0.73	NRPS	enniatin	Fusarium equiseti
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	0.70	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.70	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.69	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.68	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.73 out of 18.46

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.36 out of 23.79

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 20.58 out of 23.05

Confidence: strong

Additional weak hits (15):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.37 out of 30.22

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.14 out of 30.22

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.66 out of 27.78

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.74 out of 29.65

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.82 out of 26.06

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.07 out of 35.63

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.27 out of 36.53

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.51 out of 21.84

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.92 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.12 out of 28.14

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.93 out of 29.65

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.44 out of 25.88

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.88 out of 29.25

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.04 out of 18.57

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.77 out of 26.06

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 275694 - 337741:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (NMe-Asn) + (Pro) + (Asp)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 275694 - 328205:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (NMe-Asn) + (Pro) + (Asp)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 292077 - 333898:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (NMe-Asn) + (Pro) + (Asp)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 295827 - 337741:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (NMe-Asn) + (Pro) + (Asp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_06361: X

AMP-binding (484..887): X

nrpys: Orn, Lys, Arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DGGDIGCVDK
Nearest Stachelhaus code(s):: Orn DVGEIGSVDK (62% 8Å match); Glu DAKDIGVVDK (44% 8Å match)
Stachelhaus code match:: 70% (weak)

CDS_06366: Asn

Search NORINE for peptide: strict or relaxed

AMP-binding (506..908): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKVGEVAK
Nearest Stachelhaus code(s):: Asn DLTKVGEVGK (85% 8Å match)
Stachelhaus code match:: 90% (moderate)

CDS_06367: X

AMP-binding (26..402): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DSAVIAEVWK
Nearest Stachelhaus code(s):: His DSALIAEVWK (85% 8Å match)
Stachelhaus code match:: 90% (moderate)

CDS_06370: Pro

Search NORINE for peptide: strict or relaxed

AMP-binding (17..419): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DAQFIAHVVK
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (79% 8Å match)
Stachelhaus code match:: 90% (moderate)

CDS_06373: Asp

Search NORINE for peptide: strict or relaxed

AMP-binding (45..451): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DFTRVGHVGK
Nearest Stachelhaus code(s):: Asp DLTKVGHVGK (71% 8Å match)
Stachelhaus code match:: 80% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
IolR	Regulator of the inositol catabolism
RpoN	Regulator of nitrogen assimilation and virulence

NPDC021375.ctg-0014 - Region 1 - RiPP-like

Download region GenBank file

Download region SVG

Location: 50,958 - 63,243 nt. (total: 12,286 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: back translocase

CDS_06465: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001948.3	0.43	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0002115.3	0.43	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0000565.5	0.42	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0000483.5	0.41	ribosomal	aeruginosamide B, aeruginosamide C	Microcystis aeruginosa PCC 9432
BGC0002584.2	0.40	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0000528.5	0.40	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002485.2	0.38	other (other), ribosomal	muscoride A, muscoride B	Desmonostoc sp. PCC 7906
BGC0002551.2	0.38	other (other), ribosomal, terpene	muscoride A, muscoride B	Nostoc sp. UHCC-0398
BGC0000496.5	0.38	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000477.3	0.38	ribosomal	patellin 2, patellin 3	uncultured Prochloron sp. 06037A

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001948.3	0.43	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0002115.3	0.43	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0000565.5	0.42	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0000483.5	0.41	ribosomal	aeruginosamide B, aeruginosamide C	Microcystis aeruginosa PCC 9432
BGC0002584.2	0.40	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0000528.5	0.40	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002485.2	0.38	other (other), ribosomal	muscoride A, muscoride B	Desmonostoc sp. PCC 7906
BGC0002551.2	0.38	other (other), ribosomal, terpene	muscoride A, muscoride B	Nostoc sp. UHCC-0398
BGC0000496.5	0.38	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000477.3	0.38	ribosomal	patellin 2, patellin 3	uncultured Prochloron sp. 06037A

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.76 out of 23.79

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

Additional weak hits (4):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.73 out of 29.25

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.53 out of 20.97

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.68 out of 28.19

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.63 out of 29.65

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

RREFinder

TFBS Finder

RRE predictions

: RRE type: Goadsporin_CD_RRE; Location: 11 - 107; Score: 66.6; RRE type: NHLP_CD_RRE; Location: 10 - 103; Score: 63.1; RRE type: Cyanobactin_D_RRE; Location: 9 - 86; Score: 52.5

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
IolR	Regulator of the inositol catabolism

NPDC021375.ctg-0014 - Region 2 - NRPS-like,T1PKS,benzoxazole

Download region GenBank file

Download region SVG

Location: 67,524 - 191,943 nt. (total: 124,420 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
benzoxazole: (ksIII and AMP-binding and PP-binding and Amidohydro_1)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase phosphate reductase

CDS_06474: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CDS_06477: N-acetyl-gamma-glutamyl-phosphate reductase

smcogs: SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase

CDS_06481: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

CDS_06488: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

CDS_06494: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

CDS_06498: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CDS_06512: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

CDS_06521: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

CDS_06524: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

CDS_06527: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

CDS_06534: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

CDS_06546: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase acyltransferase aminotransferase transketolase

CDS_06478: transketolase

smcogs: SMCOG1204: transketolase

CDS_06532: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

CDS_06539: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

CDS_06540: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase phosphatase

CDS_06497: isochorismatase

smcogs: SMCOG1027: isochorismatase

CDS_06528: FkbH like protein

smcogs: SMCOG1256: FkbH like protein

Lyases: lyase

CDS_06483: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Isomerases: isomerase

CDS_06496: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

CDS_06503: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

CDS_06479: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

CDS_06480: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_06486: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_06490: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_06492: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

CDS_06501: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_06502: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

CDS_06530: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

CDS_06531: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

CDS_06535: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

CDS_06536: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

CDS_06537: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: transporter

CDS_06547: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001444.5	0.82	other (shikimate-derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0001164.3	0.78	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001249.5	0.76	NRPS	dimethylcoprogen	Alternaria alternata
BGC0002458.3	0.65	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0002164.2	0.61	NRPS	peramine	Epichloe festucae
BGC0001135.5	0.59	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.58	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.56	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.56	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001240.4	0.55	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001444.5	0.74	other (shikimate-derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0001273.3	0.74	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.74	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.74	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001249.5	0.70	NRPS	dimethylcoprogen	Alternaria alternata
BGC0002164.2	0.66	NRPS	peramine	Epichloe festucae
BGC0002458.3	0.66	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.69 out of 23.79

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.39 out of 24.78

Confidence: medium

Additional weak hits (35):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.91 out of 25.88

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.12 out of 30.25

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.42 out of 25.88

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.04 out of 25.88

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.24 out of 20.97

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.48 out of 30.25

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.12 out of 29.25

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.38 out of 21.55

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.59 out of 21.55

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.44 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.49 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.13 out of 28.14

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.05 out of 27.78

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.85 out of 30.97

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.81 out of 21.55

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.58 out of 20.01

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.94 out of 29.25

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.79 out of 29.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.62 out of 29.38

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.10 out of 25.88

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.67 out of 29.38

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.62 out of 30.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.92 out of 31.73

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.21 out of 28.14

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.39 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.46 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 20.27 out of 36.54

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.84 out of 30.22

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.76 out of 29.65

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.14 out of 28.19

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.32 out of 30.98

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.96 out of 36.53

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 67523 - 191943:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Me-redmal) + (ccmal) + (pk - pk) + (ccmal) + (ccmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 67523 - 117910:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 108513 - 191943:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - pk) + (ccmal) + (Me-redmal) + (ccmal) + (ccmal)
Non-colinear ordering:: CDS_06535 + CDS_06536 + CDS_06530 + CDS_06531 + CDS_06537

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_06480: X

AMP-binding (20..441): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: QAWMAGLCVK
Nearest Stachelhaus code(s):: Leu DAWLAGLTAK (29% 8Å match)
Stachelhaus code match:: 60% (weak)

CDS_06486: X

AMP-binding (16..428): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: SRTESTLPAK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

CDS_06490: X

AMP-binding (203..598): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GMVL-CLTVK
Nearest Stachelhaus code(s):: Boz GMVLRAVVVK (56% 8Å match)
Stachelhaus code match:: 60% (weak)

CDS_06501: X

AMP-binding (32..440): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: pip (Hpr)

Stachelhaus prediction details:

Stachelhaus sequence:: TWPSQGVLAK
Nearest Stachelhaus code(s):: Hpa TWPSQGVLCK (85% 8Å match)
Stachelhaus code match:: 90% (moderate)

CDS_06530: mmal

PKS_AT (567..860): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 190.3
Ethylmalonyl-CoA: 169.0
Methoxymalonyl-CoA: 148.4
2-Methylbutyryl-CoA: 143.8
Propionyl-CoA: 109.6
trans-1,2-CPDA: 100.9
CHC-CoA: 96.9
Malonyl-CoA: 84.9
Isobutyryl-CoA: 51.1
Benzoyl-CoA: 38.4
3-Methylbutyryl-CoA: 38.4
Acetyl-CoA: 34.9
fatty_acid: 34.5
inactive: 24.2

CDS_06531: mal

PKS_AT (593..871): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.4
inactive: 98.6
Methoxymalonyl-CoA: 67.2
Methylmalonyl-CoA: 66.5
Propionyl-CoA: 33.6
Acetyl-CoA: 32.6
Ethylmalonyl-CoA: 30.6
Isobutyryl-CoA: 30.2
Benzoyl-CoA: 27.0
CHC-CoA: 15.0
fatty_acid: 14.9
2-Methylbutyryl-CoA: 14.7
trans-1,2-CPDA: 13.9
3-Methylbutyryl-CoA: 0.0

CDS_06535: pk - pk

PKS_AT (529..824): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 228.1
Methylmalonyl-CoA: 223.3
Methoxymalonyl-CoA: 191.4
2-Methylbutyryl-CoA: 151.5
trans-1,2-CPDA: 145.5
Propionyl-CoA: 121.6
Malonyl-CoA: 111.2
CHC-CoA: 100.5
Isobutyryl-CoA: 91.3
Benzoyl-CoA: 81.1
Acetyl-CoA: 53.9
fatty_acid: 42.7
3-Methylbutyryl-CoA: 38.8
inactive: 30.0

PKS_AT (1546..1836): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 222.5
Methylmalonyl-CoA: 218.6
Methoxymalonyl-CoA: 185.5
2-Methylbutyryl-CoA: 154.1
trans-1,2-CPDA: 129.9
Propionyl-CoA: 124.1
Malonyl-CoA: 109.8
CHC-CoA: 103.2
Isobutyryl-CoA: 91.3
Benzoyl-CoA: 69.5
Acetyl-CoA: 60.7
inactive: 42.4
fatty_acid: 40.6
3-Methylbutyryl-CoA: 31.9

CDS_06536: mal

PKS_AT (571..883): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 178.2
inactive: 69.5
Methoxymalonyl-CoA: 59.3
Methylmalonyl-CoA: 48.6
Propionyl-CoA: 30.8
Isobutyryl-CoA: 29.8
Acetyl-CoA: 24.2
Ethylmalonyl-CoA: 16.1
fatty_acid: 9.7
2-Methylbutyryl-CoA: 8.5
Benzoyl-CoA: 6.8
CHC-CoA: 2.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

CDS_06537: mal

PKS_AT (579..857): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.1
inactive: 93.7
Methylmalonyl-CoA: 66.8
Methoxymalonyl-CoA: 63.7
Acetyl-CoA: 35.6
Propionyl-CoA: 32.4
Ethylmalonyl-CoA: 31.8
Isobutyryl-CoA: 29.9
Benzoyl-CoA: 23.5
2-Methylbutyryl-CoA: 21.8
fatty_acid: 18.7
CHC-CoA: 13.1
trans-1,2-CPDA: 7.4
3-Methylbutyryl-CoA: 0.0

CDS_06540: pk

PKS_AT (116..412): pk

ATSignature: Methylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 185.5
Methylmalonyl-CoA: 182.7
Methoxymalonyl-CoA: 165.0
trans-1,2-CPDA: 123.1
2-Methylbutyryl-CoA: 121.4
Propionyl-CoA: 95.0
CHC-CoA: 94.2
Malonyl-CoA: 86.3
Isobutyryl-CoA: 60.6
Benzoyl-CoA: 39.3
inactive: 37.3
3-Methylbutyryl-CoA: 36.9
Acetyl-CoA: 23.5
fatty_acid: 15.2

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response

NPDC021375.ctg-0014 - Region 3 - terpene

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Location: 211,454 - 233,437 nt. (total: 21,984 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

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other genes

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TTA codons

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Gene overview

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MIBiG comparison

ClusterBlast

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Terpene

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

CDS_06578: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

CDS_06582: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Ligases: synthetase

CDS_06580: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002043.3	0.54	ribosomal	cittilin A, cittilin B	Myxococcus xanthus DK 1622
BGC0002397.2	0.53	terpene	astallatene	Arabidopsis thaliana
BGC0000677.5	0.53	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002400.2	0.49	terpene	boleracene	Brassica oleracea var. oleracea
BGC0001911.3	0.47	terpene	raimonol	Streptomyces anulatus
BGC0002644.2	0.46	other (other), terpene	domoic acid, isodomoic acid A, isodomoic acid B, prekainic acid, 7'-carboxyN-geranyl-L-glutamic acid, isodomoic acid C	Chondria armata
BGC0000675.5	0.46	terpene	(+)-T-muurolol	Streptomyces clavuligerus ATCC 27064
BGC0002216.3	0.46	terpene	HEx-tc1 terpene	Trichoderma virens Gv29-8
BGC0002398.2	0.43	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001633.3	0.43	other (other)	ketomemicin B3, ketomemicin B4	Streptomyces mobaraensis NBRC 13819 = DSM 40847

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002043.3	0.54	ribosomal	cittilin A, cittilin B	Myxococcus xanthus DK 1622
BGC0002397.2	0.53	terpene	astallatene	Arabidopsis thaliana
BGC0000677.5	0.53	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002400.2	0.49	terpene	boleracene	Brassica oleracea var. oleracea
BGC0001911.3	0.47	terpene	raimonol	Streptomyces anulatus
BGC0002644.2	0.46	other (other), terpene	domoic acid, isodomoic acid A, isodomoic acid B, prekainic acid, 7'-carboxyN-geranyl-L-glutamic acid, isodomoic acid C	Chondria armata
BGC0000675.5	0.46	terpene	(+)-T-muurolol	Streptomyces clavuligerus ATCC 27064
BGC0002216.3	0.46	terpene	HEx-tc1 terpene	Trichoderma virens Gv29-8
BGC0002398.2	0.43	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001633.3	0.43	other (other)	ketomemicin B3, ketomemicin B4	Streptomyces mobaraensis NBRC 13819 = DSM 40847

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Chain length	Initial cyclisations	Functional groups
sesquiterpene	C15	C1-C6	none
diterpene	C20	C1-C6	none
diterpene	C20	C1-C7 + C6-C10	none
sesterterpene	C25	C1-C7 + C6-C10	none

Genes with terpene domains:

CDS_06579: TS_UbiA

Domain 1 (10 - 299): UbiA type terpene synthase

Reactions:: FPP → sesquiterpene_C1-C6; GGPP → diterpene_C1-C6; GGPP → diterpene_C1-C7/C6-C10; GFPP → sesterterpene_C1-C7/C6-C10

CDS_06580: PT_FPPS_like

Domain 1 (62 - 345): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.11 out of 19.52

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.98 out of 23.79

Confidence: medium

Additional weak hits (9):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.22 out of 26.12

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.96 out of 32.74

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.39 out of 21.55

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.85 out of 20.01

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.79 out of 27.78

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.12 out of 36.53

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.42 out of 26.12

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 23.11 out of 32.38

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.65 out of 32.93

Confidence: weak

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
IolR	Regulator of the inositol catabolism

NPDC021375.ctg-0015 - Region 1 - ectoine

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Location: 21,894 - 32,292 nt. (total: 10,399 nt) Show pHMM detection rules used

ectoine: ectoine_synt

Legend:

core biosynthetic genes

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resistance

TTA codons

binding site

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Gene details

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Gene overview

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TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

CDS_06698: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002052.3	0.82	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.82	other (other)	ectoine	Streptomyces anulatus
BGC0000852.5	0.79	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.72	other (other)	ectoine	Methylobacter marinus
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000857.3	0.59	other (other)	ectoine	Methylophaga alcalica
BGC0000854.3	0.57	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000855.3	0.55	other (other)	ectoine	Methylomicrobium kenyense
BGC0000856.3	0.55	other (other)	ectoine	Methylophaga thalassica
BGC0000860.3	0.51	other (other)	ectoine	Methylarcula marina

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002052.3	0.82	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.82	other (other)	ectoine	Streptomyces anulatus
BGC0000852.5	0.79	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.72	other (other)	ectoine	Methylobacter marinus
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000857.3	0.59	other (other)	ectoine	Methylophaga alcalica
BGC0000854.3	0.57	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000855.3	0.55	other (other)	ectoine	Methylomicrobium kenyense
BGC0000856.3	0.55	other (other)	ectoine	Methylophaga thalassica
BGC0000860.3	0.51	other (other)	ectoine	Methylarcula marina

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.11 out of 24.78

Confidence: strong

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.11 out of 19.52

Confidence: medium

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 24.07 out of 29.65

Confidence: medium

Additional weak hits (5):

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.14 out of 19.26

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.85 out of 20.01

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.89 out of 20.01

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.27 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.12 out of 29.38

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
LexA variant 1	Repressor of DNA damage response
LexA variant 2	Repressor of DNA damage response

NPDC021375.ctg-0015 - Region 2 - NAPAA,hglE-KS

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Location: 58,971 - 133,750 nt. (total: 74,780 nt) Show pHMM detection rules used

hglE-KS: (hglE or hglD)
NAPAA: (AMP-binding and TIGR02353)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

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resistance

TTA codons

binding site

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Select a gene to view the details available for it

Gene overview

Tailoring

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TFBS Finder

NRPS/PKS modules

Pfam domains

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NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CDS_06759: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CDS_06762: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase aminotransferase carboxylase

CDS_06755: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

CDS_06761: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

CDS_06774: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

CDS_06777: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: amidase esterase hydrolase

CDS_06748: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

CDS_06758: thioesterase

smcogs: SMCOG1004: thioesterase

CDS_06772: amidase

smcogs: SMCOG1105: amidase

Lyases: decarboxylase dehydratase

CDS_06745: putative carboxymuconolactone decarboxylase

smcogs: SMCOG1298: putative carboxymuconolactone decarboxylase

CDS_06756: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase

CDS_06750: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

CDS_06773: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: transport

CDS_06757: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002174.2	0.42	NRPS	ε-Poly-L-lysine	Epichloe festucae
BGC0002535.2	0.31	NRPS	γ-poly-L-2,4-diaminobutyric acid	Streptomyces celluloflavus
BGC0002135.2	0.28	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.28	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000307.4	0.27	NRPS	AbT1	Aureobasidium pullulans
BGC0001758.4	0.27	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.4	0.27	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.26	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.26	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001249.5	0.26	NRPS	dimethylcoprogen	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002174.2	0.74	NRPS	ε-Poly-L-lysine	Epichloe festucae
BGC0002535.2	0.64	NRPS	γ-poly-L-2,4-diaminobutyric acid	Streptomyces celluloflavus
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.4	0.63	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.63	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002276.2	0.63	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001132.4	0.63	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.62	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.62	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52

Confidence: strong

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.11 out of 19.52

Confidence: medium

Additional weak hits (16):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.65 out of 32.74

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.13 out of 39.62

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.98 out of 39.62

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.86 out of 32.93

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.51 out of 21.84

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.14 out of 21.84

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.63 out of 29.38

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.29 out of 18.57

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.45 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.61 out of 29.38

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.81 out of 35.63

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.64 out of 29.65

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.76 out of 21.84

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.05 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 17.32 out of 33.14

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.90 out of 27.04

Confidence: weak

Module view

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 58970 - 133750:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 99688 - 133750:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_06773: X

AMP-binding (37..430): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DFECLSAVTK
Nearest Stachelhaus code(s):: Val DFESLAAVYK (65% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production

NPDC021375.ctg-0015 - Region 3 - lassopeptide

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Location: 146,394 - 168,923 nt. (total: 22,530 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene overview

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MIBiG comparison

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Lasso peptides

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidase

CDS_06810: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CDS_06814: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

Hydrolases: back translocase hydrolase

CDS_06800: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

CDS_06807: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: dehydratase

CDS_06812: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Translocases: permease

CDS_06813: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001539.4	0.72	ribosomal	cattlecin	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0002074.2	0.72	ribosomal	huascopeptin	Streptomyces huasconensis
BGC0002053.3	0.72	ribosomal	ulleungdin	Streptomyces sp.
BGC0001779.5	0.71	ribosomal	siamycin	Streptomyces nodosus
BGC0001507.3	0.70	ribosomal	anantin C	Streptomyces olindensis
BGC0001493.5	0.69	ribosomal	achromosin	Streptomyces achromogenes subsp. achromogenes
BGC0002307.3	0.62	ribosomal	humidimycin	Streptomyces humidus
BGC0001674.5	0.62	ribosomal	MS-271	Streptomyces mirabilis
BGC0001920.4	0.62	ribosomal	siamycin I	Streptomyces sp.
BGC0002015.4	0.62	ribosomal	aborycin	Streptomyces sp. ZS0098

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001539.4	0.72	ribosomal	cattlecin	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0002074.2	0.72	ribosomal	huascopeptin	Streptomyces huasconensis
BGC0002053.3	0.72	ribosomal	ulleungdin	Streptomyces sp.
BGC0001779.5	0.71	ribosomal	siamycin	Streptomyces nodosus
BGC0001507.3	0.70	ribosomal	anantin C	Streptomyces olindensis
BGC0001493.5	0.69	ribosomal	achromosin	Streptomyces achromogenes subsp. achromogenes
BGC0002307.3	0.62	ribosomal	humidimycin	Streptomyces humidus
BGC0001674.5	0.62	ribosomal	MS-271	Streptomyces mirabilis
BGC0001920.4	0.62	ribosomal	siamycin I	Streptomyces sp.
BGC0002015.4	0.62	ribosomal	aborycin	Streptomyces sp. ZS0098

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 24.03 out of 25.31

Confidence: strong

Additional weak hits (10):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.21 out of 26.33

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.84 out of 26.33

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.88 out of 21.55

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.09 out of 30.11

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.24 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.40 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.10 out of 26.06

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.98 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.91 out of 28.19

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.15 out of 35.63

Confidence: weak

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

No core peptides found.

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 0 - 85; Score: 78.4

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor

NPDC021375.ctg-0015 - Region 4 - atropopeptide

Download region GenBank file

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Location: 181,907 - 202,989 nt. (total: 21,083 nt) Show pHMM detection rules used

atropopeptide: atropopeptide_p450

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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MIBiG comparison

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TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

CDS_06837: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

CDS_06839: Biaryl bond formation

MITE: MITE0000173Biaryl bond formation (identity: 87.60%)
smcogs: SMCOG1034: cytochrome P450

Hydrolases: hydrolase

CDS_06843: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Ligases: oxygenase

CDS_06839: Biaryl bond formation

MITE: MITE0000173Biaryl bond formation (identity: 87.60%)
smcogs: SMCOG1034: cytochrome P450

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002751.2	0.51	ribosomal	Amyxirubin B	Amycolatopsis xylanica
BGC0000527.5	0.39	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000559.4	0.37	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000043.5	0.37	PKS	curacin A	Moorea producens 19L
BGC0000506.4	0.37	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000511.5	0.36	ribosomal	ericin S	Bacillus subtilis
BGC0000842.5	0.36	other (non-nrp beta-lactam)	carbapenem MM4550	Streptomyces argenteolus
BGC0000547.5	0.34	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000197.5	0.34	PKS, saccharide	aranciamycin	Streptomyces echinatus
BGC0000503.5	0.34	ribosomal	cinnamycin	Streptomyces cinnamoneus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002751.2	0.51	ribosomal	Amyxirubin B	Amycolatopsis xylanica
BGC0000527.5	0.39	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000559.4	0.37	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000043.5	0.37	PKS	curacin A	Moorea producens 19L
BGC0000506.4	0.37	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000511.5	0.36	ribosomal	ericin S	Bacillus subtilis
BGC0000842.5	0.36	other (non-nrp beta-lactam)	carbapenem MM4550	Streptomyces argenteolus
BGC0000547.5	0.34	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000197.5	0.34	PKS, saccharide	aranciamycin	Streptomyces echinatus
BGC0000503.5	0.34	ribosomal	cinnamycin	Streptomyces cinnamoneus

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.71 out of 25.88

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 24.84 out of 29.72

Confidence: medium

Additional weak hits (3):

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.57 out of 24.78

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.10 out of 29.65

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.39 out of 28.19

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
NtrC	Nitrogen regulatory protein C
PsrA	Oleic acid responsive regulator

NPDC021375.ctg-0018 - Region 1 - NRPS,NRPS-like

Download region GenBank file

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Location: 106,366 - 160,418 nt. (total: 54,053 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

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other genes

resistance

TTA codons

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

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TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

CDS_07618: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CDS_07626: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

CDS_07637: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: methyltransferase

CDS_07604: methyltransferase

smcogs: SMCOG1089: methyltransferase

CDS_07634: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: hydrolase peptidase

CDS_07630: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

CDS_07639: gamma-glutamyltranspeptidase

smcogs: SMCOG1274: gamma-glutamyltranspeptidase

Ligases: ligase

CDS_07629: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_07631: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_07632: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.85	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.82	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.82	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.82	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002135.2	0.79	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002286.3	0.77	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.77	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.76	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001261.3	0.74	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.73	NRPS	enniatin	Fusarium equiseti

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.73	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.73	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002135.2	0.72	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002286.3	0.71	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.71	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.70	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 18.08 out of 25.31

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 25.84 out of 30.12

Confidence: medium

Additional weak hits (14):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.66 out of 32.74

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.46 out of 25.75

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.02 out of 26.85

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.10 out of 27.78

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.71 out of 26.85

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 39.62

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.19 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.28 out of 26.06

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.10 out of 21.55

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.43 out of 27.04

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 22.08 out of 32.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.73 out of 29.38

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.21 out of 36.53

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.99 out of 26.06

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 106365 - 160418:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Pro) + (X) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 106365 - 148195:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Pro) + (X) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 110082 - 160418:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Pro) + (X) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_07629: X

AMP-binding (11..416): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DARHASLMTK
Nearest Stachelhaus code(s):: Ala DAWHISLMDK (47% 8Å match)
Stachelhaus code match:: 70% (weak)

CDS_07631: X

AMP-binding (469..866): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLADLGLVDK
Nearest Stachelhaus code(s):: Thr DLWQLGLVHK (38% 8Å match)
Stachelhaus code match:: 70% (weak)

CDS_07632: X - Pro

Search NORINE for peptide: strict or relaxed

AMP-binding (465..864): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DGLHSGGVDK
Nearest Stachelhaus code(s):: mTyr or ohdmTyr DGSHSGDVWK (59% 8Å match); OH-Orn DGEGSGGVTK (50% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1524..1938): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVWCGGLLVK
Nearest Stachelhaus code(s):: 4Me-Pro or Pro DVQYGGHLVK (79% 8Å match); Arg DVWCFGLVDK (53% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CatR	H2O2-responsive repressor
OsdR	Development and stress management regulator
VqsM	Regulator of quorum-sensing signalling systems

NPDC021375.ctg-0018 - Region 2 - RRE-containing

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Location: 207,048 - 223,023 nt. (total: 15,976 nt) Show pHMM detection rules used

Region on contig edge.

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.75	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0000542.3	0.40	ribosomal	paenicidin B	Paenibacillus terrae
BGC0001289.5	0.39	ribosomal	penisin	Paenibacillus ehimensis
BGC0000541.5	0.39	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0001727.3	0.35	ribosomal	paenilan	Paenibacillus polymyxa E681
BGC0000529.5	0.33	ribosomal	microbisporicin A2	Microbispora corallina
BGC0002448.2	0.27	NRPS	Q6402A	Streptomyces violaceusniger
BGC0000957.5	0.22	NRPS, PKS	mycotrienin I	Streptomyces sp. XZQH13
BGC0001762.3	0.20	other (other)	rubrolone A, rubrolone B	Streptomyces sp. KIB-H033

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.75	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0000542.3	0.40	ribosomal	paenicidin B	Paenibacillus terrae
BGC0001289.5	0.39	ribosomal	penisin	Paenibacillus ehimensis
BGC0000541.5	0.39	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0001727.3	0.35	ribosomal	paenilan	Paenibacillus polymyxa E681
BGC0000529.5	0.33	ribosomal	microbisporicin A2	Microbispora corallina
BGC0002448.2	0.27	NRPS	Q6402A	Streptomyces violaceusniger
BGC0000957.5	0.22	NRPS, PKS	mycotrienin I	Streptomyces sp. XZQH13
BGC0001762.3	0.20	other (other)	rubrolone A, rubrolone B	Streptomyces sp. KIB-H033

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 20.76 out of 21.84

Confidence: strong

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 20.08 out of 23.43

Confidence: medium

Additional weak hits (9):

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.92 out of 23.43

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.85 out of 36.54

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.85 out of 26.12

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.33 out of 25.88

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.16 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.30 out of 26.06

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.03 out of 32.74

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.86 out of 30.25

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.59 out of 18.57

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

RREFinder

TFBS Finder

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 22 - 114; Score: 72.4

TFBS definitions

Regulator	Description
BldD	Development and antibiotic global regulator
MexT	Global virulence regulator

NPDC021375.ctg-0019 - Region 1 - NRPS-like

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Location: 57,886 - 100,570 nt. (total: 42,685 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

CDS_07770: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

CDS_07774: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: hydrolase

CDS_07764: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Ligases: ligase

CDS_07771: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CDS_07778: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002277.2	0.64	NRPS	atromentin	Suillus grevillei
BGC0002274.2	0.64	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0002193.2	0.63	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0001128.4	0.63	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.63	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.62	NRPS	AbT1	Aureobasidium pullulans
BGC0002276.2	0.60	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002164.2	0.60	NRPS	peramine	Epichloe festucae
BGC0001268.4	0.59	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001164.3	0.57	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002277.2	0.64	NRPS	atromentin	Suillus grevillei
BGC0002274.2	0.64	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0002193.2	0.63	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0001128.4	0.63	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.63	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.62	NRPS	AbT1	Aureobasidium pullulans
BGC0002276.2	0.60	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002164.2	0.60	NRPS	peramine	Epichloe festucae
BGC0001268.4	0.59	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001164.3	0.57	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (13):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.19 out of 20.97

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.27 out of 29.25

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.28 out of 26.33

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.73 out of 29.25

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.68 out of 20.97

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.07 out of 25.88

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 24.18 out of 30.22

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.41 out of 26.33

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.33 out of 32.93

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.89 out of 29.65

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.04 out of 29.65

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.96 out of 29.25

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 57885 - 100570:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_07778: fatty_acid

CAL_domain (34..421): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 20.1
Acetyl-CoA: 10.3
shikimic_acid: 0.0
NH2: 0.0
AHBA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description

NPDC021375.ctg-0019 - Region 2 - NRPS,T1PKS,terpene

Download region GenBank file

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Location: 112,551 - 204,956 nt. (total: 92,406 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

CDS_07819: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

CDS_07820: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

CDS_07825: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

CDS_07835: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CDS_07838: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

CDS_07860: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

CDS_07861: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: acylase halogenase methyltransferase

CDS_07818: methyltransferase

smcogs: SMCOG1089: methyltransferase

CDS_07836: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

CDS_07850: halogenase

smcogs: SMCOG1119: halogenase

Hydrolases: esterase hydrolase

CDS_07828: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

CDS_07831: thioesterase

smcogs: SMCOG1004: thioesterase

CDS_07837: thioesterase

smcogs: SMCOG1004: thioesterase

CDS_07846: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: cyclase

CDS_07817: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Ligases: ligase synthase

CDS_07832: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_07833: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

CDS_07834: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

CDS_07847: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CDS_07848: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CDS_07849: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_07852: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CDS_07856: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

CDS_07859: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000658.3	1.87	terpene	2-methylisoborneol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000659.3	1.54	terpene	2-methylisoborneol	Saccharopolyspora erythraea NRRL 2338
BGC0001273.3	1.39	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	1.38	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	1.38	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000041.3	1.12	PKS	oronofacic acid	Pseudomonas syringae
BGC0002135.2	1.09	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	1.08	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	1.06	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	1.06	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000658.3	0.85	terpene	2-methylisoborneol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000659.3	0.79	terpene	2-methylisoborneol	Saccharopolyspora erythraea NRRL 2338
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.74	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0000041.3	0.72	PKS	oronofacic acid	Pseudomonas syringae
BGC0001128.4	0.72	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
monoterpene		2-methylisoborneol	C11	C1-C6	OH
monoterpene		2-methylenebornane	C11	C1-C6	none

Genes with terpene domains:

CDS_07817: T1TS

Domain 1 (10 - 388): Type 1 terpene synthase

Subtype: 2-Methylisoborneol synthase type

Reactions:: 2-MeGPP → 2-methylisoborneol; 2-MeGPP → 2-methylenebornane

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.65 out of 18.46

Confidence: strong

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.28 out of 19.52

Confidence: medium

Additional weak hits (16):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.27 out of 30.97

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 16.78 out of 26.12

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.86 out of 26.85

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.16 out of 28.14

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.94 out of 27.55

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.18 out of 30.25

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 16.78 out of 26.12

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.46 out of 32.74

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.68 out of 35.63

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.75 out of 35.63

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.99 out of 36.53

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.13 out of 24.78

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.39 out of 27.04

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.81 out of 29.65

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Terpene

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 112550 - 204956:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X - Gly) + (D-X - X) + (NMe-Val) + (pk) + (ccemal) + (redmal) + (Me-mal) + (Val)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 117474 - 160741:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk) + (ccemal) + (redmal) + (Me-mal) + (Val)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 120871 - 179392:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X - X) + (NMe-Val) + (pk) + (ccemal) + (redmal) + (Me-mal) + (Val)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 6, location 150544 - 204956:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X - Gly) + (D-X - X) + (NMe-Val) + (pk) + (ccemal) + (redmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_07832: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (497..887): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: EALWWGGGFK
Nearest Stachelhaus code(s):: 3OH-Leu DTLWWGGGFK (85% 8Å match); Val or aIle DALWWGGVFK (74% 8Å match)
Stachelhaus code match:: 80% (moderate)

CDS_07833: mmal

PKS_AT (574..870): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.0
Ethylmalonyl-CoA: 204.3
Methoxymalonyl-CoA: 178.9
2-Methylbutyryl-CoA: 155.9
trans-1,2-CPDA: 137.4
Propionyl-CoA: 119.4
Malonyl-CoA: 109.5
CHC-CoA: 97.3
Isobutyryl-CoA: 92.2
Benzoyl-CoA: 64.4
Acetyl-CoA: 43.0
3-Methylbutyryl-CoA: 41.3
fatty_acid: 32.8
inactive: 31.1

CDS_07834: mal

PKS_AT (572..867): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 66.7%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 151.0
Methylmalonyl-CoA: 75.7
Methoxymalonyl-CoA: 68.3
inactive: 51.3
Ethylmalonyl-CoA: 38.5
Propionyl-CoA: 34.7
Benzoyl-CoA: 31.8
Isobutyryl-CoA: 26.7
CHC-CoA: 26.7
2-Methylbutyryl-CoA: 24.9
Acetyl-CoA: 23.6
fatty_acid: 21.4
trans-1,2-CPDA: 20.6
3-Methylbutyryl-CoA: 0.0

CDS_07835: emal

PKS_AT (607..905): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 91.7%; Methoxymalonyl-CoA: 83.3%; Methylmalonyl-CoA: 83.3%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 190.7
Methylmalonyl-CoA: 182.9
Methoxymalonyl-CoA: 164.6
trans-1,2-CPDA: 117.1
Malonyl-CoA: 105.8
2-Methylbutyryl-CoA: 101.9
CHC-CoA: 92.6
Propionyl-CoA: 85.0
Isobutyryl-CoA: 81.1
Benzoyl-CoA: 42.7
inactive: 40.2
Acetyl-CoA: 36.4
fatty_acid: 25.8
3-Methylbutyryl-CoA: 25.5

CDS_07836: pk

PKS_AT (539..834): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 207.7
Methylmalonyl-CoA: 199.0
Methoxymalonyl-CoA: 166.0
trans-1,2-CPDA: 118.2
2-Methylbutyryl-CoA: 115.0
Malonyl-CoA: 104.9
Propionyl-CoA: 103.5
CHC-CoA: 98.1
Benzoyl-CoA: 59.9
Isobutyryl-CoA: 57.7
Acetyl-CoA: 45.2
inactive: 37.5
3-Methylbutyryl-CoA: 33.4
fatty_acid: 22.4

CDS_07847: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (466..845): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DAPFEALVEK
Nearest Stachelhaus code(s):: Val DAPFEALVEK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

CDS_07848: X - X

AMP-binding (465..868): X

nrpys: Piz

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVFSIAAYAK
Nearest Stachelhaus code(s):: Piz DVFSIAAYAK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2027..2418): X

nrpys: 3R-oh-3-mePro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DVFCNSSYAK
Nearest Stachelhaus code(s):: 3R-oh-3-mePro DVFCNSSYAK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

CDS_07849: X - Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (465..861): X

nrpys: Piz

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVFSVASYAK
Nearest Stachelhaus code(s):: Piz DVFSVASYAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2017..2393): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGVIWK
Nearest Stachelhaus code(s):: Gly DILQLGVIWK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

CDS_07852: X

AMP-binding (19..425): X

nrpys: Leu, Ala

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLRHLGQDVK
Nearest Stachelhaus code(s):: Leu or Ala DLRHLGQDVK (100% 8Å match); Leu or Ser DLRHLGQDVK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

Glossary

Acronym	Full name
2-MeGPP	2-methylgeranyl diphosphate

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
RpoN	Regulator of nitrogen assimilation and virulence

NPDC021375.ctg-0021 - Region 1 - T1PKS

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Location: 49,186 - 121,097 nt. (total: 71,912 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxidoreductase oxygenase

CDS_08043: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

CDS_08045: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

CDS_08047: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

CDS_08056: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

CDS_08059: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CDS_08060: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase aminotransferase

CDS_08046: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

CDS_08049: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

CDS_08054: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Lyases: decarboxylase

CDS_08063: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Isomerases: racemase

CDS_08058: mandelate racemase/muconate lactonizing enzyme

smcogs: SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Ligases: synthase

CDS_08048: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

CDS_08050: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

CDS_08053: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	0.74	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001533.5	0.67	PKS	borrelidin	Streptomyces rochei
BGC0000031.5	0.64	PKS	borrelidin	Streptomyces parvulus
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002154.2	0.64	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.64	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	0.74	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001533.5	0.67	PKS	borrelidin	Streptomyces rochei
BGC0000031.5	0.64	PKS	borrelidin	Streptomyces parvulus
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002154.2	0.64	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.64	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84

Confidence: medium

Additional weak hits (12):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.48 out of 28.14

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 18.70 out of 26.12

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.14 out of 19.26

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.13 out of 26.33

Confidence: weak

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 17.99 out of 25.31

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.71 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.89 out of 26.06

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.26 out of 20.97

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.96 out of 28.14

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.52 out of 27.55

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.40 out of 26.06

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.41 out of 28.19

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 49185 - 121097:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (ohmal) + (ccmal) + (Me-ohmal) + (Me-redmal) + (ohmal)
Non-colinear ordering:: CDS_08054 + CDS_08053 + CDS_08052 + CDS_08050 + CDS_08049 + CDS_08048

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_08048: mal

PKS_AT (569..852): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.0
inactive: 91.2
Methoxymalonyl-CoA: 60.2
Methylmalonyl-CoA: 58.6
Acetyl-CoA: 31.3
Propionyl-CoA: 27.5
Isobutyryl-CoA: 24.2
Benzoyl-CoA: 23.5
Ethylmalonyl-CoA: 21.9
2-Methylbutyryl-CoA: 14.2
CHC-CoA: 13.5
fatty_acid: 12.8
trans-1,2-CPDA: 10.6
3-Methylbutyryl-CoA: 0.0

CDS_08049: mmal

PKS_AT (558..852): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 213.7
Ethylmalonyl-CoA: 206.0
Methoxymalonyl-CoA: 178.6
2-Methylbutyryl-CoA: 142.1
trans-1,2-CPDA: 138.1
Malonyl-CoA: 132.8
Propionyl-CoA: 125.7
CHC-CoA: 107.8
Isobutyryl-CoA: 74.9
Benzoyl-CoA: 70.8
Acetyl-CoA: 52.5
3-Methylbutyryl-CoA: 41.3
fatty_acid: 39.0
inactive: 36.0

CDS_08050: mmal

PKS_AT (560..852): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.9
Ethylmalonyl-CoA: 196.5
Methoxymalonyl-CoA: 184.8
2-Methylbutyryl-CoA: 137.3
Malonyl-CoA: 130.1
trans-1,2-CPDA: 126.8
Propionyl-CoA: 123.2
CHC-CoA: 105.4
Isobutyryl-CoA: 71.1
Benzoyl-CoA: 69.0
Acetyl-CoA: 51.1
3-Methylbutyryl-CoA: 38.7
inactive: 36.2
fatty_acid: 34.3

CDS_08052: mal

PKS_AT (564..856): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.7
inactive: 83.1
Methoxymalonyl-CoA: 58.6
Methylmalonyl-CoA: 47.5
Propionyl-CoA: 35.8
Isobutyryl-CoA: 29.2
Acetyl-CoA: 27.2
Benzoyl-CoA: 21.1
Ethylmalonyl-CoA: 19.4
fatty_acid: 16.8
CHC-CoA: 13.5
2-Methylbutyryl-CoA: 12.1
trans-1,2-CPDA: 6.7
3-Methylbutyryl-CoA: 0.0

CDS_08053: mal

PKS_AT (571..849): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.3
inactive: 96.3
Methylmalonyl-CoA: 70.9
Methoxymalonyl-CoA: 68.8
Ethylmalonyl-CoA: 38.7
Acetyl-CoA: 33.9
Isobutyryl-CoA: 33.5
Propionyl-CoA: 31.4
Benzoyl-CoA: 26.8
fatty_acid: 18.4
2-Methylbutyryl-CoA: 14.2
trans-1,2-CPDA: 14.1
CHC-CoA: 12.7
3-Methylbutyryl-CoA: 0.0

CDS_08054: pk

PKS_AT (357..655): pk

ATSignature: trans-1,2-CPDA

Top 3 matches:: trans-1,2-CPDA: 95.8%; Ethylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 235.7
Ethylmalonyl-CoA: 176.5
Methylmalonyl-CoA: 171.1
Methoxymalonyl-CoA: 155.8
2-Methylbutyryl-CoA: 135.7
Propionyl-CoA: 109.6
CHC-CoA: 89.8
Malonyl-CoA: 65.2
Benzoyl-CoA: 59.4
Acetyl-CoA: 57.4
Isobutyryl-CoA: 52.8
fatty_acid: 30.6
3-Methylbutyryl-CoA: 27.1
inactive: 16.9

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
MexT	Global virulence regulator

NPDC021375.ctg-0021 - Region 2 - azole-containing-RiPP

Download region GenBank file

Download region SVG

Location: 131,929 - 160,498 nt. (total: 28,570 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

CDS_08092: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Transferases: methyltransferase

CDS_08093: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: deacetylase hydrolase

CDS_08074: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

CDS_08078: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

CDS_08081: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002043.3	0.55	ribosomal	cittilin A, cittilin B	Myxococcus xanthus DK 1622
BGC0002699.2	0.52	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0002698.2	0.52	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001555.4	0.52	ribosomal	colicin V	Escherichia coli chi7122
BGC0000565.5	0.51	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0002551.2	0.51	other (other), ribosomal, terpene	muscoride A, muscoride B	Nostoc sp. UHCC-0398
BGC0000590.5	0.51	ribosomal	microcin N	Escherichia coli
BGC0002005.2	0.51	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000483.5	0.51	ribosomal	aeruginosamide B, aeruginosamide C	Microcystis aeruginosa PCC 9432
BGC0001262.3	0.51	PKS	AK-toxin I	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002043.3	0.55	ribosomal	cittilin A, cittilin B	Myxococcus xanthus DK 1622
BGC0002699.2	0.52	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0002698.2	0.52	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001555.4	0.52	ribosomal	colicin V	Escherichia coli chi7122
BGC0000565.5	0.51	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0002551.2	0.51	other (other), ribosomal, terpene	muscoride A, muscoride B	Nostoc sp. UHCC-0398
BGC0000590.5	0.51	ribosomal	microcin N	Escherichia coli
BGC0002005.2	0.51	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000483.5	0.51	ribosomal	aeruginosamide B, aeruginosamide C	Microcystis aeruginosa PCC 9432
BGC0001262.3	0.51	PKS	AK-toxin I	Alternaria alternata

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 22.47 out of 25.31

Confidence: strong

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 23.74 out of 27.04

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.03 out of 29.72

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.17 out of 25.31

Confidence: medium

Additional weak hits (8):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.73 out of 31.73

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.51 out of 21.55

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.16 out of 29.65

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.79 out of 26.85

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 19.95 out of 30.98

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.60 out of 29.65

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.63 out of 29.65

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

RREFinder

TFBS Finder

Azole RiPPs

RRE predictions

: RRE type: NHLP_CD_RRE; Location: 2 - 93; Score: 43.4; RRE type: Cyanobactin_D_RRE; Location: 2 - 78; Score: 39.5; RRE type: Goadsporin_CD_RRE; Location: 4 - 97; Score: 38.8

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
DasR	N-acetylglucosamine dependent repressor
NtrC	Nitrogen regulatory protein C

Core peptide predictions

No core peptides found.

NPDC021375.ctg-0022 - Region 1 - lanthipeptide-class-ii

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Location: 56,826 - 84,841 nt. (total: 28,016 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

CDS_08172: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Lyases: cyclase

CDS_08169: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

CDS_08171: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002110.3	0.71	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001229.4	0.66	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000520.5	0.59	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000528.5	0.59	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000555.3	0.58	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0000516.4	0.55	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000503.5	0.54	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0000623.3	0.53	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001210.5	0.53	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001311.5	0.52	ribosomal	flavecins	Ruminococcus flavefaciens FD-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002110.3	0.71	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001229.4	0.66	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000520.5	0.59	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000528.5	0.59	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000555.3	0.58	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0000516.4	0.55	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000503.5	0.54	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0000623.3	0.53	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001210.5	0.53	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001311.5	0.52	ribosomal	flavecins	Ruminococcus flavefaciens FD-1

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for CDS_08169

CDS_08167

Leader:

MVPFEGDLPLVEEIAEQDFDDVAYGA

Core:

CSTNTFSLSDYYGNQGNWCTLTRECINGC

Core with dehydrations:

CysDhaDhbNDhbFDhaLDhaDYYGNQGNWCysDhbLDhbRECysINGCys

antiSMASH-DB 4.0 matches for CDS_08167

76.7%

NZ_BLIS01000009.1and 7 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide

Lanthipeptides: GVO03_RS04820_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

C+TNTFSLSDY+GN+GNWCTLT EC+N C

1

CTTNTFSLSDYWGNKGNWCTLTHECMNWC

29

73.3%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

CSTNTFSLSD+ GNQG WCTLT+EC C

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNC

29

73.3%

NZ_CACZYW010000004.1and 1 other:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide

Lanthipeptides: HUF10_RS02825_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

CSTNTFSLSDY+GN GNWCTL+ EC+ C

1

CSTNTFSLSDYWGNNGNWCTLSHECMAWC

29

with 99 more sequence matches

Only the first 10 are displayed here.

73.3%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide

Lanthipeptides: allorf_0097945_0098112_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

CSTNTFSLSDY+GN+G WCTLT EC++ C

1

CSTNTFSLSDYWGNRGYWCTLTHECMSWC

29

73.3%

NZ_QGEE01000020.1and 5 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide

Lanthipeptides: DKP74_RS06160_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

CSTNTFSLSDY+GN+GNWCTL+ EC+ C

1

CSTNTFSLSDYWGNRGNWCTLSHECMAWC

29

70.0%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide

Lanthipeptides: PO853_RS06515_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

C+TNTFSLSDY+GN+GNWCT T EC+ C

1

CTTNTFSLSDYWGNKGNWCTATHECMGWC

29

70.0%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide

Lanthipeptides: OGH68_RS19760_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

C+TNTFSLSD+ GNQG WCTLT+EC C

1

CTTNTFSLSDWLGNQGGWCTLTKECQPNC

29

70.0%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide

Lanthipeptides: BJR39_RS08305_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

CSTNTFSLSDY+GN GNWCT + EC++ C

1

CSTNTFSLSDYWGNNGNWCTASHECMSWC

29

70.0%

NZ_FNHR01000005.1and 1 other:

NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05590_lanthipeptide

Lanthipeptides: BLQ37_RS05590_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

CSTNTFSLSDY GN GNWCT++ EC+ C

1

CSTNTFSLSDYMGNNGNWCTISHECMAWC

29

70.0%

NZ_JAJAGO010000028.1and 1 other:

NZ_JAJAGO010000028.1 Lanthipeptides: LHJ74_RS33590_lanthipeptide

Lanthipeptides: LHJ74_RS33590_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

CSTNTFSLSD GN G WCTLT+EC C

1

CSTNTFSLSDAAGNDGWWCTLTKECQRTC

29

70.0%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide

Lanthipeptides: CQS04_RS09620_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

C+TNTFSLSDY+GN GNWCT T EC++ C

1

CTTNTFSLSDYWGNNGNWCTATHECMSWC

29

66.7%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

C+TNTFSLSD GN G WCTLT+EC C

1

CTTNTFSLSDALGNHGGWCTLTKECQANC

29

66.7%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

C+TNTFSLSD GN G WCTLT EC C

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNC

29

MIBiG 4.0 matches for CDS_08167

63.3%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

C+TNTFSLS+ GN G WCTLT+EC C

1

CTTNTFSLSNALGNNGGWCTLTKECQPNC

29

37.9%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

6

FSLSDYYGNQGNWCTLTRECINGC

29

+++S GN+G +CTLT EC+ C

4

YNISCRLGNKGAYCTLTVECMPSC

27

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

19

CTLTRECINGC

29

CTL++EC C

28

CTLSKECQPNC

38

CDS_08168

Leader:

MEEKQDDILGRHDELDLVELSGEGVYGG

Core:

TLWVCQTVTLVSSIFCPTTACTTQC

Core with dehydrations:

DhbLWVCysQDhbVDhbLVDhaDhaIFCysPDhbDhbACysDhbDhbQCys

antiSMASH-DB 4.0 matches for CDS_08168

55.2%

NZ_JABBGE010000004.1and 1 other:

NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide

Lanthipeptides: HHL19_RS13570_lanthipeptide

1

TLWVCQTVT----LVSSIFCPTTACTTQC

25

T W C VT LVS+ CPTT CT+QC

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

44.8%

NZ_CP042598.1and 3 others:

NZ_CP042598.1 Lanthipeptides: FUT28_RS13815_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide

Lanthipeptides: FUT28_RS13815_lanthipeptide

1

TLWVC---QTVTLVSSIFCPTTACTTQC

25

T W C T+ S CPTT CT+QC

1

TTWACVAVSTIVDASISLCPTTKCTSQC

28

44.8%

NZ_JADPDT010000005.1and 1 other:

NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09875_lanthipeptide

Lanthipeptides: I4V19_RS09875_lanthipeptide

1

TLWVC---QTVTLVSSIFCPTTACTTQC

25

T W C TV S CPTT CT++C

1

TTWACVAVSTVVEASISLCPTTKCTSKC

28

with 101 more sequence matches

Only the first 10 are displayed here.

44.0%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide

Lanthipeptides: EL241_RS13590_lanthipeptide

7

TVTLVSSI-FCPTTACTTQC

25

TVT+ SI CPT CT++C

4

TVTVPLSIALCPTAKCTSKC

23

41.7%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06300_lanthipeptide

Lanthipeptides: EG886_RS06300_lanthipeptide

1

TLWVCQTVTLVSSIFCPTTACTTQC

25

TL VC V+L FCPTTACT+ C

14

TLAVCVPVSLA---FCPTTACTSDC

35

39.3%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide

Lanthipeptides: LDO05_RS02090_lanthipeptide

3

WVCQTVTLVSSIFCPTTACTTQC

25

W+C + S+ FCP+TACT++C

9

WICG---VASAAFCPSTACTSKC

28

38.5%

NC_017299.1and 1 other:

NC_017299.1 Lanthipeptides: H04402_RS03100_lanthipeptide

Lanthipeptides: H04402_RS03100_lanthipeptide

7

TVTLVSSIFCPTTACTTQC

25

+ T VS++F T+ACTT+C

7

SATAVSALFTVTSACTTKC

25

38.5%

NZ_CP016767.1and 13 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptideNZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptideNZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

11

VSSIFCPTTACTTQC

25

+SS CPTTACT C

12

ISSNTCPTTACTRAC

26

38.1%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS09415_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptide

Lanthipeptides: IEY56_RS09415_lanthipeptide

1

TLWVCQTVTLVSSIFCPTTACTTQC

25

T WVC TVTL ++ CPTT CT+QC

18

TAWVCATVTLATAAICPTTKCTSQC

42

37.5%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08310_lanthipeptide

Lanthipeptides: BJR39_RS08310_lanthipeptide

8

VTLVSSIFCPTTACTTQC

25

VT VS+ CPTTACT C

15

VTYVSNQTCPTTACTRAC

32

37.0%

NZ_CP114065.1:

Lanthipeptides: OX958_RS04330_lanthipeptide

2

LWVCQTVTLVSSIFCPTTA

20

L V +VT+ SSI P TA

9

LAVSDSVTICSSISAPVTA

27

36.7%

NZ_QGEE01000020.1and 3 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide

Lanthipeptides: DKP74_RS06165_lanthipeptide

10

LVSSIFCPTTACTTQC

25

VSS CPTTACT C

15

FVSSHTCPTTACTRAC

30

36.4%

NZ_QORY01000016.1and 1 other:

NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide

Lanthipeptides: DT250_RS18265_lanthipeptide

1

TLWVCQTVTLVSSIFCPTTACTTQC

25

T W C T+ S+ CPTTAC+++C

8

TTWGCAIFTIASAAQCPTTACSSKC

32

MIBiG 4.0 matches for CDS_08168

30.8%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

15

FCPTTACTTQC

25

FCPTT CT++C

16

FCPTTKCTSKC

26

27.0%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

11

VSSIFCPTTACTTQC

25

VS+ FCPTT CT++C

23

VSAAFCPTTKCTSRC

37

allorf_059075_059257

Leader:

MGGIRVRGGRRRRRAGA

Core:

GRRVRCTDEPFDVGSGRLSVASDALGARGRGEQSGDERVDQLG

Core with dehydrations:

GRRVRCysDhbDEPFDVGDhaGRLDhaVADhaDALGARGRGEQDhaGDERVDQLG

antiSMASH-DB 4.0 matches for allorf_059075_059257

18.6%

NZ_CP017171.1:

Lanthipeptides: allorf_7652556_7652741_lanthipeptide

10

PFDVGSGRLSVA

21

PFD GS R VA

28

PFDTGSVRRHVA

39

16.3%

NC_015711.1and 1 other:

NZ_CP022203.1 Lanthipeptides: allorf_3348101_3348274_lanthipeptide

Lanthipeptides: allorf_5227001_5227174_lanthipeptide

16

GRLSVASDALGARGR

30

++SV ++ALG GR

19

AQVSVTANALGPEGR

33

16.3%

NZ_BMJA01000001.1:

Lanthipeptides: allorf_0181822_0181917_lanthipeptide

5

RCTDEPFDVGSGRLS

19

RC EP SG+ S

7

RCQAEPHRCASGKTS

21

with 2 more sequence matches

16.3%

NZ_BNAV01000001.1:

Lanthipeptides: allorf_1531220_1531375_lanthipeptide

5

RCTDEPFDVGSGRLSVAS

22

+C PF + GR+S+ S

4

QCGLPPFSLPRGRVSMLS

21

16.3%

NZ_JAGGRJ010000031.1:

Lanthipeptides: allorf_016614_016724_lanthipeptide

4

VRCTDEPFDVGSGRL

18

VR T PF++ GR+

4

VRATPPPFNLCLGRI

18

allorf_062366_062548

Leader:

MMTATWGDGNKDLPVQAA

Core:

GRRRPSPLPRHSPRRRRPPPGAGLRWCSAPPCWASSSSHWTR

Core with dehydrations:

GRRRPDhaPLPRHDhaPRRRRPPPGAGLRWCysDhaAPPCysWADhaDhaDhaDhaHWDhbR

antiSMASH-DB 4.0 matches for allorf_062366_062548

20.8%

NZ_JACDUR010000006.1:

Lanthipeptides: allorf_021997_022233_lanthipeptide

2

RRRPSPLPRHSPRRRRPP

19

RR+PS L R SP+R PP

27

RRQPSLLLRGSPKRHEPP

44

17.5%

NZ_CP011020.1:

Lanthipeptides: allorf_1834656_1834892_lanthipeptide

6

SPLPRHSPRRRRPPPGAGLRWCSAPP

31

P P H RRP PGA C + P

27

EPFPSHEKNDRRPRPGAKPETCGSEP

52

14.7%

NZ_QFWW01000059.1:

Lanthipeptides: allorf_187545_187781_lanthipeptide

1

GRRRPSPLPRHSPRRRRPPPGAG

23

G R + RH RRPP G G

36

GEARSALGVRHGVGDRRPPTGRG

58

MIBiG 4.0 matches for allorf_062366_062548

9.5%

BGC0002150.2 (MBO0654592.1):

Lasso peptide: triculamin

16

RRPPPGAGLR

25

++ PG G+R

2

KKSKPGDGIR

11

allorf_064850_065068

Leader:

MGRVAEAGS

Core:

DSPPSVPRPAAERDEASRPRRRRTHRARRPPGRPWPGPGQVSGCDQSVGLVVTATRNRWIFLL

Core with dehydrations:

DDhaPPDhaVPRPAAERDEADhaRPRRRRDhbHRARRPPGRPWPGPGQVDhaGCysDQDhaVGLVVDhbADhbRNRWIFLL

antiSMASH-DB 4.0 matches for allorf_064850_065068

11.1%

NZ_BMRB01000009.1and 3 others:

NZ_BMRB01000009.1 Lanthipeptides: IEY98_RS29710_lanthipeptideNZ_CP031087.1 Lanthipeptides: Actkin_RS26635_lanthipeptideNZ_CP031087.1 Lanthipeptides: Actkin_RS26635_lanthipeptide

Lanthipeptides: IEY98_RS29710_lanthipeptide

23

RTHRARRPPGRPWPGPGQVSGCDQSVG

49

+ + ++ GR P P + CD+++G

13

KGYLSKVENGRARPNPALAALCDRALG

39

MIBiG 4.0 matches for allorf_064850_065068

11.1%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

14

DEASRPRRRRTHRARRPP

31

DE+SRP H P

30

DESSRPAAPACHTLSSLP

47

allorf_065822_066016

Leader:

MLDTIAIRGVPSRGRAEAGA

Core:

GPGRQGVPVRPCSVPCRDRRRGRRADHPRRPSSCGWRPGPSFPG

Core with dehydrations:

GPGRQGVPVRPCysDhaVPCysRDRRRGRRADHPRRPDhaDhaCysGWRPGPDhaFPG

antiSMASH-DB 4.0 matches for allorf_065822_066016

31.8%

NZ_CP034350.1and 3 others:

NZ_CP034350.1 Lanthipeptides: allorf_1143579_1143785_lanthipeptideNZ_CP034350.1 Lanthipeptides: allorf_1143579_1143785_lanthipeptideNZ_CP034350.1 Lanthipeptides: allorf_1143579_1143785_lanthipeptide

Lanthipeptides: allorf_1143579_1143785_lanthipeptide

2

PGRQGVPVRPCSVPCRDRRRGRR

24

PGR G PVRP P R R GRR

11

PGRSGHPVRPGH-PLRTDRHGRR

32

27.5%

NZ_LIPG01000002.1and 1 other:

NZ_LIPG01000002.1 Lanthipeptides: allorf_0371938_0372126_lanthipeptide

Lanthipeptides: allorf_0371938_0372126_lanthipeptide

1

GPGRQGVPVRPC----------SVPCRDRRR

21

GPGRQG +RP S P +DRRR

8

GPGRQGSGMRPGRCGPRTDVRRSAPRKDRRR

38

22.7%

NZ_CP120210.1:

Lanthipeptides: P3102_RS07330_lanthipeptide

8

PVRPCSVPCRDRRRGRRADHPR

29

P PCS+PC GR A R

2

PTIPCSIPCTRICTGRTACCSR

23

with 5 more sequence matches

20.5%

NZ_FQZK01000006.1and 2 others:

NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13065_lanthipeptideNZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13065_lanthipeptide

Lanthipeptides: BUE45_RS13065_lanthipeptide

1

GPGRQGVPVRPCSVPCRDRRRG

22

GPG VPV + PC D+ +

12

GPGEGAVPVTDPAQPCDDKEKA

33

20.5%

NZ_JANZKX010000002.1:

Lanthipeptides: allorf_602154_602312_lanthipeptide

3

GRQGV---PVRPCSVPC

16

GRQ + PV PC +PC

5

GRQALRRTPVNPCRLPC

21

18.2%

NZ_JAPFGB010000043.1:

Lanthipeptides: allorf_24720_24848_lanthipeptide

7

VPVRPCSVPCRDRRRGR

23

V VR + C R RGR

3

VAVRDLEISCSARARGR

19

15.9%

NZ_CP041613.2:

Lanthipeptides: allorf_01196898_01197128_lanthipeptide

28

PRRPSSCGWRPGPSFP

43

PRR SC W G +

1

PRRCRSCSWLHGHALT

16

13.6%

NZ_JARJVU010000021.1:

Lanthipeptides: P3195_RS10555_lanthipeptide

34

CGWRPGPSFPG

44

CGW G F G

1

CGWVGGGIFTG

11

allorf_066060_066257

Leader:

MEHPARGRRGIGRAYARHRRRIARESCAG

Core:

DCCGCACQRSAKTGSGSLSVPGPRKVTETAIMNPHN

Core with dehydrations:

DCysCysGCysACysQRDhaAKDhbGDhaGDhaLDhaVPGPRKVDhbEDhbAIMNPHN

antiSMASH-DB 4.0 matches for allorf_066060_066257

16.7%

NZ_LMHM01000001.1:

Lanthipeptides: allorf_734038_734136_lanthipeptide

21

PGPRKVTETAIMNP

34

PGP K + ++M P

4

PGPGKRSRVSVMQP

17

16.7%

NZ_QRDO01000002.1:

Lanthipeptides: allorf_1054818_1054979_lanthipeptide

19

SVPGPRKVTETA

30

S+PGP K+ +A

2

SLPGPEKIFPSA

13

16.3%

NZ_PUPX01000001.1:

Lanthipeptides: allorf_1091992_1092165_lanthipeptide

3

CGCACQRSAK

12

CGC+C R AK

34

CGCSCVRDAK

43

with 3 more sequence matches

14.3%

NZ_CP097290.1:

Lanthipeptides: allorf_006508_006717_lanthipeptide

2

CCGCACQRSAKTGSGSLSVP

21

CCG + ++ G LS+P

2

CCGTDGTQKSRHARGVLSLP

21

12.3%

NZ_BNAY01000001.1:

Lanthipeptides: allorf_1318663_1318878_lanthipeptide

15

SGSLSVPGPRKVTETAIMNP

34

SG+L+VP P + ++ P

1

SGTLNVPDPPLIKVVPVLGP

20

10.2%

NZ_FOGI01000013.1:

Lanthipeptides: BMY07_RS27410_lanthipeptide

7

CQRSAKTGSGSLSVPGPRKV

26

C S + +++ P PRK+

36

CDYSGWAPAAAITTPNPRKI

55

allorf_066136_066348

Leader:

MFFLSPWMTQDAARMVLSAFLIFIVHDRSMRGA

Core:

SREREERHRARIRTTSPSHRKGIVRGRLLRVCVSTLR

Core with dehydrations:

DhaREREERHRARIRDhbDhbDhaPDhaHRKGIVRGRLLRVCysVDhaDhbLR

antiSMASH-DB 4.0 matches for allorf_066136_066348

27.0%

NZ_CP095274.1:

Lanthipeptides: allorf_2244352_2244492_lanthipeptide

12

IRTTSPSHRKGIVRGRLL

29

+ T+ PSHRK V RLL

2

VFTSGPSHRK--VTARLL

17

24.3%

NZ_CP007155.1:

Lanthipeptides: allorf_5635321_5635545_lanthipeptide

11

RIRTTSPSHRKGIVR

25

RIRT SPS + I R

1

RIRTGSPSGAESIER

15

19.0%

NZ_BMJA01000001.1:

Lanthipeptides: allorf_0188877_0189029_lanthipeptide

17

PSHRKGIVRGRLLRVCVSTL

36

P+ R G+ +CVSTL

1

PACRGSPPPGKPASMCVSTL

20

with 1 more sequence matches

18.9%

NZ_LMFT01000038.1and 1 other:

NZ_LMFT01000038.1 Lanthipeptides: allorf_017162_017272_lanthipeptide

Lanthipeptides: allorf_017162_017272_lanthipeptide

17

PSHRKGIVRGRLLRV

31

P+H VRG +RV

8

PAHEAAWVRGTEMRV

22

allorf_077097_077222

Leader:

MAVSLPVRSSRAAAEPGS

Core:

LRGADSCRRSLWNHHDWVGRARR

Core with dehydrations:

LRGADDhaCysRRDhaLWNHHDWVGRARR

antiSMASH-DB 4.0 matches for allorf_077097_077222

26.5%

NZ_CP073318.1:

Lanthipeptides: allorf_01122276_01122440_lanthipeptide

6

SCRRSLWNHHDWVGRARR

23

S RR LWN G +RR

10

SIRRGLWNLPACAGNSRR

27

allorf_077219_077452

Leader:

MTVRVRRSDVLAM

Core:

SARPPLAPVSHPFSSIPPAWPQRWPAAQGRRESAVRAVLSASEQILAARPLGAKPFRRSPKCLS

Core with dehydrations:

DhaARPPLAPVDhaHPFDhaDhaIPPAWPQRWPAAQGRREDhaAVRAVLDhaADhaEQILAARPLGAKPFRRDhaPKCysLDha

MIBiG 4.0 matches for allorf_077219_077452

10.9%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

5

PLAPVSHPFSSIP

17

P AP H SS+P

35

PAAPACHTLSSLP

47

allorf_077758_077979

Leader:

MISGYGNLAGA

Core:

AFTCTPTPLRRQARRKPRGSAHRAEPRPDPVPADRPEHHGPDAMDAVTSVDAANNIGTLITG

Core with dehydrations:

AFDhbCysDhbPDhbPLRRQARRKPRGDhaAHRAEPRPDPVPADRPEHHGPDAMDAVDhbDhaVDAANNIGDhbLIDhbG

antiSMASH-DB 4.0 matches for allorf_077758_077979

12.9%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: allorf_1271752_1271961_lanthipeptide

Lanthipeptides: allorf_1271752_1271961_lanthipeptide

3

TCTPTPLRRQAR

14

+CT LRRQAR

38

SCTLRSLRRQAR

49

allorf_077848_078039

Leader:

MQPSFRSRKRRRTSLHTRFRLTRYQSSNIIGG

Core:

VHARYGIHGIRAVMLGPVCRDRVGSWLCSMS

Core with dehydrations:

VHARYGIHGIRAVMLGPVCysRDRVGDhaWLCysDhaMDha

antiSMASH-DB 4.0 matches for allorf_077848_078039

22.5%

NZ_CP058277.1:

Lanthipeptides: allorf_2528982_2529143_lanthipeptide

2

HARYGIHGIRAVMLGPVCRDRVGSWLCSM

30

HAR H A L P C W+ ++

1

HARRRFHRPTAAALVPNCPGSTNRWVSTL

29

Lanthipeptide(s) for CDS_08171

CDS_08167

Leader:

MVPFEGDLPLVEEIAEQDFDDVAYGA

Core:

CSTNTFSLSDYYGNQGNWCTLTRECINGC

Core with dehydrations:

CysDhaDhbNDhbFDhaLDhaDYYGNQGNWCysDhbLDhbRECysINGCys

antiSMASH-DB 4.0 matches for CDS_08167

76.7%

NZ_BLIS01000009.1and 7 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide

Lanthipeptides: GVO03_RS04820_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

C+TNTFSLSDY+GN+GNWCTLT EC+N C

1

CTTNTFSLSDYWGNKGNWCTLTHECMNWC

29

73.3%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

CSTNTFSLSD+ GNQG WCTLT+EC C

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNC

29

73.3%

NZ_CACZYW010000004.1and 1 other:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide

Lanthipeptides: HUF10_RS02825_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

CSTNTFSLSDY+GN GNWCTL+ EC+ C

1

CSTNTFSLSDYWGNNGNWCTLSHECMAWC

29

with 99 more sequence matches

Only the first 10 are displayed here.

73.3%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide

Lanthipeptides: allorf_0097945_0098112_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

CSTNTFSLSDY+GN+G WCTLT EC++ C

1

CSTNTFSLSDYWGNRGYWCTLTHECMSWC

29

73.3%

NZ_QGEE01000020.1and 5 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide

Lanthipeptides: DKP74_RS06160_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

CSTNTFSLSDY+GN+GNWCTL+ EC+ C

1

CSTNTFSLSDYWGNRGNWCTLSHECMAWC

29

70.0%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide

Lanthipeptides: PO853_RS06515_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

C+TNTFSLSDY+GN+GNWCT T EC+ C

1

CTTNTFSLSDYWGNKGNWCTATHECMGWC

29

70.0%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide

Lanthipeptides: OGH68_RS19760_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

C+TNTFSLSD+ GNQG WCTLT+EC C

1

CTTNTFSLSDWLGNQGGWCTLTKECQPNC

29

70.0%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide

Lanthipeptides: BJR39_RS08305_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

CSTNTFSLSDY+GN GNWCT + EC++ C

1

CSTNTFSLSDYWGNNGNWCTASHECMSWC

29

70.0%

NZ_FNHR01000005.1and 1 other:

NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05590_lanthipeptide

Lanthipeptides: BLQ37_RS05590_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

CSTNTFSLSDY GN GNWCT++ EC+ C

1

CSTNTFSLSDYMGNNGNWCTISHECMAWC

29

70.0%

NZ_JAJAGO010000028.1and 1 other:

NZ_JAJAGO010000028.1 Lanthipeptides: LHJ74_RS33590_lanthipeptide

Lanthipeptides: LHJ74_RS33590_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

CSTNTFSLSD GN G WCTLT+EC C

1

CSTNTFSLSDAAGNDGWWCTLTKECQRTC

29

70.0%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide

Lanthipeptides: CQS04_RS09620_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

C+TNTFSLSDY+GN GNWCT T EC++ C

1

CTTNTFSLSDYWGNNGNWCTATHECMSWC

29

66.7%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

C+TNTFSLSD GN G WCTLT+EC C

1

CTTNTFSLSDALGNHGGWCTLTKECQANC

29

66.7%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

C+TNTFSLSD GN G WCTLT EC C

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNC

29

MIBiG 4.0 matches for CDS_08167

63.3%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

1

CSTNTFSLSDYYGNQGNWCTLTRECINGC

29

C+TNTFSLS+ GN G WCTLT+EC C

1

CTTNTFSLSNALGNNGGWCTLTKECQPNC

29

37.9%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

6

FSLSDYYGNQGNWCTLTRECINGC

29

+++S GN+G +CTLT EC+ C

4

YNISCRLGNKGAYCTLTVECMPSC

27

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

19

CTLTRECINGC

29

CTL++EC C

28

CTLSKECQPNC

38

CDS_08168

Leader:

MEEKQDDILGRHDELDLVELSGEGVYGG

Core:

TLWVCQTVTLVSSIFCPTTACTTQC

Core with dehydrations:

DhbLWVCysQDhbVDhbLVDhaDhaIFCysPDhbDhbACysDhbDhbQCys

antiSMASH-DB 4.0 matches for CDS_08168

55.2%

NZ_JABBGE010000004.1and 1 other:

NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide

Lanthipeptides: HHL19_RS13570_lanthipeptide

1

TLWVCQTVT----LVSSIFCPTTACTTQC

25

T W C VT LVS+ CPTT CT+QC

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

44.8%

NZ_CP042598.1and 3 others:

NZ_CP042598.1 Lanthipeptides: FUT28_RS13815_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide

Lanthipeptides: FUT28_RS13815_lanthipeptide

1

TLWVC---QTVTLVSSIFCPTTACTTQC

25

T W C T+ S CPTT CT+QC

1

TTWACVAVSTIVDASISLCPTTKCTSQC

28

44.8%

NZ_JADPDT010000005.1and 1 other:

NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09875_lanthipeptide

Lanthipeptides: I4V19_RS09875_lanthipeptide

1

TLWVC---QTVTLVSSIFCPTTACTTQC

25

T W C TV S CPTT CT++C

1

TTWACVAVSTVVEASISLCPTTKCTSKC

28

with 101 more sequence matches

Only the first 10 are displayed here.

44.0%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide

Lanthipeptides: EL241_RS13590_lanthipeptide

7

TVTLVSSI-FCPTTACTTQC

25

TVT+ SI CPT CT++C

4

TVTVPLSIALCPTAKCTSKC

23

41.7%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06300_lanthipeptide

Lanthipeptides: EG886_RS06300_lanthipeptide

1

TLWVCQTVTLVSSIFCPTTACTTQC

25

TL VC V+L FCPTTACT+ C

14

TLAVCVPVSLA---FCPTTACTSDC

35

39.3%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide

Lanthipeptides: LDO05_RS02090_lanthipeptide

3

WVCQTVTLVSSIFCPTTACTTQC

25

W+C + S+ FCP+TACT++C

9

WICG---VASAAFCPSTACTSKC

28

38.5%

NC_017299.1and 1 other:

NC_017299.1 Lanthipeptides: H04402_RS03100_lanthipeptide

Lanthipeptides: H04402_RS03100_lanthipeptide

7

TVTLVSSIFCPTTACTTQC

25

+ T VS++F T+ACTT+C

7

SATAVSALFTVTSACTTKC

25

38.5%

NZ_CP016767.1and 13 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptideNZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptideNZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

11

VSSIFCPTTACTTQC

25

+SS CPTTACT C

12

ISSNTCPTTACTRAC

26

38.1%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS09415_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptide

Lanthipeptides: IEY56_RS09415_lanthipeptide

1

TLWVCQTVTLVSSIFCPTTACTTQC

25

T WVC TVTL ++ CPTT CT+QC

18

TAWVCATVTLATAAICPTTKCTSQC

42

37.5%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08310_lanthipeptide

Lanthipeptides: BJR39_RS08310_lanthipeptide

8

VTLVSSIFCPTTACTTQC

25

VT VS+ CPTTACT C

15

VTYVSNQTCPTTACTRAC

32

37.0%

NZ_CP114065.1:

Lanthipeptides: OX958_RS04330_lanthipeptide

2

LWVCQTVTLVSSIFCPTTA

20

L V +VT+ SSI P TA

9

LAVSDSVTICSSISAPVTA

27

36.7%

NZ_QGEE01000020.1and 3 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide

Lanthipeptides: DKP74_RS06165_lanthipeptide

10

LVSSIFCPTTACTTQC

25

VSS CPTTACT C

15

FVSSHTCPTTACTRAC

30

36.4%

NZ_QORY01000016.1and 1 other:

NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide

Lanthipeptides: DT250_RS18265_lanthipeptide

1

TLWVCQTVTLVSSIFCPTTACTTQC

25

T W C T+ S+ CPTTAC+++C

8

TTWGCAIFTIASAAQCPTTACSSKC

32

MIBiG 4.0 matches for CDS_08168

30.8%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

15

FCPTTACTTQC

25

FCPTT CT++C

16

FCPTTKCTSKC

26

27.0%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

11

VSSIFCPTTACTTQC

25

VS+ FCPTT CT++C

23

VSAAFCPTTKCTSRC

37

allorf_062366_062548

Leader:

MMTATWGDGNKDLPVQAA

Core:

GRRRPSPLPRHSPRRRRPPPGAGLRWCSAPPCWASSSSHWTR

Core with dehydrations:

GRRRPDhaPLPRHDhaPRRRRPPPGAGLRWCysDhaAPPCysWADhaDhaDhaDhaHWDhbR

antiSMASH-DB 4.0 matches for allorf_062366_062548

20.8%

NZ_JACDUR010000006.1:

Lanthipeptides: allorf_021997_022233_lanthipeptide

2

RRRPSPLPRHSPRRRRPP

19

RR+PS L R SP+R PP

27

RRQPSLLLRGSPKRHEPP

44

17.5%

NZ_CP011020.1:

Lanthipeptides: allorf_1834656_1834892_lanthipeptide

6

SPLPRHSPRRRRPPPGAGLRWCSAPP

31

P P H RRP PGA C + P

27

EPFPSHEKNDRRPRPGAKPETCGSEP

52

14.7%

NZ_QFWW01000059.1:

Lanthipeptides: allorf_187545_187781_lanthipeptide

1

GRRRPSPLPRHSPRRRRPPPGAG

23

G R + RH RRPP G G

36

GEARSALGVRHGVGDRRPPTGRG

58

MIBiG 4.0 matches for allorf_062366_062548

9.5%

BGC0002150.2 (MBO0654592.1):

Lasso peptide: triculamin

16

RRPPPGAGLR

25

++ PG G+R

2

KKSKPGDGIR

11

allorf_064850_065068

Leader:

MGRVAEAGS

Core:

DSPPSVPRPAAERDEASRPRRRRTHRARRPPGRPWPGPGQVSGCDQSVGLVVTATRNRWIFLL

Core with dehydrations:

DDhaPPDhaVPRPAAERDEADhaRPRRRRDhbHRARRPPGRPWPGPGQVDhaGCysDQDhaVGLVVDhbADhbRNRWIFLL

antiSMASH-DB 4.0 matches for allorf_064850_065068

11.1%

NZ_BMRB01000009.1and 3 others:

NZ_BMRB01000009.1 Lanthipeptides: IEY98_RS29710_lanthipeptideNZ_CP031087.1 Lanthipeptides: Actkin_RS26635_lanthipeptideNZ_CP031087.1 Lanthipeptides: Actkin_RS26635_lanthipeptide

Lanthipeptides: IEY98_RS29710_lanthipeptide

23

RTHRARRPPGRPWPGPGQVSGCDQSVG

49

+ + ++ GR P P + CD+++G

13

KGYLSKVENGRARPNPALAALCDRALG

39

MIBiG 4.0 matches for allorf_064850_065068

11.1%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

14

DEASRPRRRRTHRARRPP

31

DE+SRP H P

30

DESSRPAAPACHTLSSLP

47

allorf_065822_066016

Leader:

MLDTIAIRGVPSRGRAEAGA

Core:

GPGRQGVPVRPCSVPCRDRRRGRRADHPRRPSSCGWRPGPSFPG

Core with dehydrations:

GPGRQGVPVRPCysDhaVPCysRDRRRGRRADHPRRPDhaDhaCysGWRPGPDhaFPG

antiSMASH-DB 4.0 matches for allorf_065822_066016

31.8%

NZ_CP034350.1and 3 others:

NZ_CP034350.1 Lanthipeptides: allorf_1143579_1143785_lanthipeptideNZ_CP034350.1 Lanthipeptides: allorf_1143579_1143785_lanthipeptideNZ_CP034350.1 Lanthipeptides: allorf_1143579_1143785_lanthipeptide

Lanthipeptides: allorf_1143579_1143785_lanthipeptide

2

PGRQGVPVRPCSVPCRDRRRGRR

24

PGR G PVRP P R R GRR

11

PGRSGHPVRPGH-PLRTDRHGRR

32

27.5%

NZ_LIPG01000002.1and 1 other:

NZ_LIPG01000002.1 Lanthipeptides: allorf_0371938_0372126_lanthipeptide

Lanthipeptides: allorf_0371938_0372126_lanthipeptide

1

GPGRQGVPVRPC----------SVPCRDRRR

21

GPGRQG +RP S P +DRRR

8

GPGRQGSGMRPGRCGPRTDVRRSAPRKDRRR

38

22.7%

NZ_CP120210.1:

Lanthipeptides: P3102_RS07330_lanthipeptide

8

PVRPCSVPCRDRRRGRRADHPR

29

P PCS+PC GR A R

2

PTIPCSIPCTRICTGRTACCSR

23

with 5 more sequence matches

20.5%

NZ_FQZK01000006.1and 2 others:

NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13065_lanthipeptideNZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13065_lanthipeptide

Lanthipeptides: BUE45_RS13065_lanthipeptide

1

GPGRQGVPVRPCSVPCRDRRRG

22

GPG VPV + PC D+ +

12

GPGEGAVPVTDPAQPCDDKEKA

33

20.5%

NZ_JANZKX010000002.1:

Lanthipeptides: allorf_602154_602312_lanthipeptide

3

GRQGV---PVRPCSVPC

16

GRQ + PV PC +PC

5

GRQALRRTPVNPCRLPC

21

18.2%

NZ_JAPFGB010000043.1:

Lanthipeptides: allorf_24720_24848_lanthipeptide

7

VPVRPCSVPCRDRRRGR

23

V VR + C R RGR

3

VAVRDLEISCSARARGR

19

15.9%

NZ_CP041613.2:

Lanthipeptides: allorf_01196898_01197128_lanthipeptide

28

PRRPSSCGWRPGPSFP

43

PRR SC W G +

1

PRRCRSCSWLHGHALT

16

13.6%

NZ_JARJVU010000021.1:

Lanthipeptides: P3195_RS10555_lanthipeptide

34

CGWRPGPSFPG

44

CGW G F G

1

CGWVGGGIFTG

11

allorf_066060_066257

Leader:

MEHPARGRRGIGRAYARHRRRIARESCAG

Core:

DCCGCACQRSAKTGSGSLSVPGPRKVTETAIMNPHN

Core with dehydrations:

DCysCysGCysACysQRDhaAKDhbGDhaGDhaLDhaVPGPRKVDhbEDhbAIMNPHN

antiSMASH-DB 4.0 matches for allorf_066060_066257

16.7%

NZ_LMHM01000001.1:

Lanthipeptides: allorf_734038_734136_lanthipeptide

21

PGPRKVTETAIMNP

34

PGP K + ++M P

4

PGPGKRSRVSVMQP

17

16.7%

NZ_QRDO01000002.1:

Lanthipeptides: allorf_1054818_1054979_lanthipeptide

19

SVPGPRKVTETA

30

S+PGP K+ +A

2

SLPGPEKIFPSA

13

16.3%

NZ_PUPX01000001.1:

Lanthipeptides: allorf_1091992_1092165_lanthipeptide

3

CGCACQRSAK

12

CGC+C R AK

34

CGCSCVRDAK

43

with 3 more sequence matches

14.3%

NZ_CP097290.1:

Lanthipeptides: allorf_006508_006717_lanthipeptide

2

CCGCACQRSAKTGSGSLSVP

21

CCG + ++ G LS+P

2

CCGTDGTQKSRHARGVLSLP

21

12.3%

NZ_BNAY01000001.1:

Lanthipeptides: allorf_1318663_1318878_lanthipeptide

15

SGSLSVPGPRKVTETAIMNP

34

SG+L+VP P + ++ P

1

SGTLNVPDPPLIKVVPVLGP

20

10.2%

NZ_FOGI01000013.1:

Lanthipeptides: BMY07_RS27410_lanthipeptide

7

CQRSAKTGSGSLSVPGPRKV

26

C S + +++ P PRK+

36

CDYSGWAPAAAITTPNPRKI

55

allorf_066136_066348

Leader:

MFFLSPWMTQDAARMVLSAFLIFIVHDRSMRGA

Core:

SREREERHRARIRTTSPSHRKGIVRGRLLRVCVSTLR

Core with dehydrations:

DhaREREERHRARIRDhbDhbDhaPDhaHRKGIVRGRLLRVCysVDhaDhbLR

antiSMASH-DB 4.0 matches for allorf_066136_066348

27.0%

NZ_CP095274.1:

Lanthipeptides: allorf_2244352_2244492_lanthipeptide

12

IRTTSPSHRKGIVRGRLL

29

+ T+ PSHRK V RLL

2

VFTSGPSHRK--VTARLL

17

24.3%

NZ_CP007155.1:

Lanthipeptides: allorf_5635321_5635545_lanthipeptide

11

RIRTTSPSHRKGIVR

25

RIRT SPS + I R

1

RIRTGSPSGAESIER

15

19.0%

NZ_BMJA01000001.1:

Lanthipeptides: allorf_0188877_0189029_lanthipeptide

17

PSHRKGIVRGRLLRVCVSTL

36

P+ R G+ +CVSTL

1

PACRGSPPPGKPASMCVSTL

20

with 1 more sequence matches

18.9%

NZ_LMFT01000038.1and 1 other:

NZ_LMFT01000038.1 Lanthipeptides: allorf_017162_017272_lanthipeptide

Lanthipeptides: allorf_017162_017272_lanthipeptide

17

PSHRKGIVRGRLLRV

31

P+H VRG +RV

8

PAHEAAWVRGTEMRV

22

allorf_077097_077222

Leader:

MAVSLPVRSSRAAAEPGS

Core:

LRGADSCRRSLWNHHDWVGRARR

Core with dehydrations:

LRGADDhaCysRRDhaLWNHHDWVGRARR

antiSMASH-DB 4.0 matches for allorf_077097_077222

26.5%

NZ_CP073318.1:

Lanthipeptides: allorf_01122276_01122440_lanthipeptide

6

SCRRSLWNHHDWVGRARR

23

S RR LWN G +RR

10

SIRRGLWNLPACAGNSRR

27

allorf_077219_077452

Leader:

MTVRVRRSDVLAM

Core:

SARPPLAPVSHPFSSIPPAWPQRWPAAQGRRESAVRAVLSASEQILAARPLGAKPFRRSPKCLS

Core with dehydrations:

DhaARPPLAPVDhaHPFDhaDhaIPPAWPQRWPAAQGRREDhaAVRAVLDhaADhaEQILAARPLGAKPFRRDhaPKCysLDha

MIBiG 4.0 matches for allorf_077219_077452

10.9%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

5

PLAPVSHPFSSIP

17

P AP H SS+P

35

PAAPACHTLSSLP

47

allorf_077758_077979

Leader:

MISGYGNLAGA

Core:

AFTCTPTPLRRQARRKPRGSAHRAEPRPDPVPADRPEHHGPDAMDAVTSVDAANNIGTLITG

Core with dehydrations:

AFDhbCysDhbPDhbPLRRQARRKPRGDhaAHRAEPRPDPVPADRPEHHGPDAMDAVDhbDhaVDAANNIGDhbLIDhbG

antiSMASH-DB 4.0 matches for allorf_077758_077979

12.9%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: allorf_1271752_1271961_lanthipeptide

Lanthipeptides: allorf_1271752_1271961_lanthipeptide

3

TCTPTPLRRQAR

14

+CT LRRQAR

38

SCTLRSLRRQAR

49

allorf_077848_078039

Leader:

MQPSFRSRKRRRTSLHTRFRLTRYQSSNIIGG

Core:

VHARYGIHGIRAVMLGPVCRDRVGSWLCSMS

Core with dehydrations:

VHARYGIHGIRAVMLGPVCysRDRVGDhaWLCysDhaMDha

antiSMASH-DB 4.0 matches for allorf_077848_078039

22.5%

NZ_CP058277.1:

Lanthipeptides: allorf_2528982_2529143_lanthipeptide

2

HARYGIHGIRAVMLGPVCRDRVGSWLCSM

30

HAR H A L P C W+ ++

1

HARRRFHRPTAAALVPNCPGSTNRWVSTL

29

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.64 out of 26.33

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.90 out of 26.85

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.93 out of 23.79

Confidence: medium

Additional weak hits (7):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.25 out of 30.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.60 out of 31.73

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.28 out of 35.63

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.75 out of 29.65

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.23 out of 29.65

Confidence: weak

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Lanthipeptides

TFBS Finder

Core peptide predictions

CDS_08167 - Class II

Cleavage pHMM score: -2.20

RODEO score: 0

Monoisotopic mass: 3123.3 Da

Molecular weight: 3125.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3143.4 Da N = 1; 3161.4 Da N = 2; 3179.4 Da N = 3

CDS_08168 - Class II

Cleavage pHMM score: -3.10

RODEO score: 0

Monoisotopic mass: 2543.3 Da

Molecular weight: 2545.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 2563.0 Da N = 1; 2581.0 Da N = 2; 2599.0 Da N = 3; 2617.1 Da N = 4; 2635.1 Da N = 5

allorf_059075_059257 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 4440.2 Da

Molecular weight: 4442.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4460.8 Da N = 1; 4478.8 Da N = 2; 4496.8 Da N = 3; 4514.8 Da N = 4

allorf_062366_062548 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 4667.5 Da

Molecular weight: 4670.3 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4688.3 Da N = 1; 4706.3 Da N = 2; 4724.4 Da N = 3; 4742.4 Da N = 4; 4760.4 Da N = 5; 4778.4 Da N = 6

allorf_064850_065068 - Class II

Cleavage pHMM score: -3.80

RODEO score: 0

Monoisotopic mass: 6932.7 Da

Molecular weight: 6936.8 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 6954.8 Da N = 1; 6972.8 Da N = 2; 6990.8 Da N = 3; 7008.9 Da N = 4; 7026.9 Da N = 5; 7044.9 Da N = 6; 7062.9 Da N = 7

allorf_065822_066016 - Class II

Cleavage pHMM score: -2.20

RODEO score: 0

Monoisotopic mass: 4789.5 Da

Molecular weight: 4792.4 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 4810.4 Da N = 1

allorf_066060_066257 - Class II

Cleavage pHMM score: -5.00

RODEO score: 0

Monoisotopic mass: 3548.7 Da

Molecular weight: 3551.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3569.0 Da N = 1; 3587.1 Da N = 2; 3605.1 Da N = 3

allorf_066136_066348 - Class II

Cleavage pHMM score: -3.20

RODEO score: 0

Monoisotopic mass: 4297.5 Da

Molecular weight: 4300.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4318.0 Da N = 1; 4336.0 Da N = 2; 4354.0 Da N = 3; 4372.0 Da N = 4; 4390.1 Da N = 5; 4408.1 Da N = 6

allorf_077097_077222 - Class II

Cleavage pHMM score: -3.30

RODEO score: 0

Monoisotopic mass: 2767.4 Da

Molecular weight: 2769.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2787.1 Da N = 1

allorf_077219_077452 - Class II

Cleavage pHMM score: -2.30

RODEO score: 0

Monoisotopic mass: 6744.7 Da

Molecular weight: 6748.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 6766.8 Da N = 1; 6784.8 Da N = 2; 6802.8 Da N = 3; 6820.8 Da N = 4; 6838.8 Da N = 5; 6856.9 Da N = 6; 6874.9 Da N = 7; 6892.9 Da N = 8

allorf_077758_077979 - Class II

Cleavage pHMM score: -3.20

RODEO score: 0

Monoisotopic mass: 6503.4 Da

Molecular weight: 6507.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 6525.2 Da N = 1; 6543.2 Da N = 2; 6561.2 Da N = 3; 6579.3 Da N = 4; 6597.3 Da N = 5; 6615.3 Da N = 6; 6633.3 Da N = 7

allorf_077848_078039 - Class II

Cleavage pHMM score: -2.70

RODEO score: 0

Monoisotopic mass: 3371.7 Da

Molecular weight: 3374.0 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3392.0 Da N = 1

CDS_08167 - Class II

Cleavage pHMM score: -2.20

RODEO score: 0

Monoisotopic mass: 3123.3 Da

Molecular weight: 3125.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3143.4 Da N = 1; 3161.4 Da N = 2; 3179.4 Da N = 3

CDS_08168 - Class II

Cleavage pHMM score: -3.10

RODEO score: 0

Monoisotopic mass: 2543.3 Da

Molecular weight: 2545.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 2563.0 Da N = 1; 2581.0 Da N = 2; 2599.0 Da N = 3; 2617.1 Da N = 4; 2635.1 Da N = 5

allorf_062366_062548 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 4667.5 Da

Molecular weight: 4670.3 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4688.3 Da N = 1; 4706.3 Da N = 2; 4724.4 Da N = 3; 4742.4 Da N = 4; 4760.4 Da N = 5; 4778.4 Da N = 6

allorf_064850_065068 - Class II

Cleavage pHMM score: -3.80

RODEO score: 0

Monoisotopic mass: 6932.7 Da

Molecular weight: 6936.8 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 6954.8 Da N = 1; 6972.8 Da N = 2; 6990.8 Da N = 3; 7008.9 Da N = 4; 7026.9 Da N = 5; 7044.9 Da N = 6; 7062.9 Da N = 7

allorf_065822_066016 - Class II

Cleavage pHMM score: -2.20

RODEO score: 0

Monoisotopic mass: 4789.5 Da

Molecular weight: 4792.4 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 4810.4 Da N = 1

allorf_066060_066257 - Class II

Cleavage pHMM score: -5.00

RODEO score: 0

Monoisotopic mass: 3548.7 Da

Molecular weight: 3551.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3569.0 Da N = 1; 3587.1 Da N = 2; 3605.1 Da N = 3

allorf_066136_066348 - Class II

Cleavage pHMM score: -3.20

RODEO score: 0

Monoisotopic mass: 4297.5 Da

Molecular weight: 4300.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4318.0 Da N = 1; 4336.0 Da N = 2; 4354.0 Da N = 3; 4372.0 Da N = 4; 4390.1 Da N = 5; 4408.1 Da N = 6

allorf_077097_077222 - Class II

Cleavage pHMM score: -3.30

RODEO score: 0

Monoisotopic mass: 2767.4 Da

Molecular weight: 2769.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2787.1 Da N = 1

allorf_077219_077452 - Class II

Cleavage pHMM score: -2.30

RODEO score: 0

Monoisotopic mass: 6744.7 Da

Molecular weight: 6748.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 6766.8 Da N = 1; 6784.8 Da N = 2; 6802.8 Da N = 3; 6820.8 Da N = 4; 6838.8 Da N = 5; 6856.9 Da N = 6; 6874.9 Da N = 7; 6892.9 Da N = 8

allorf_077758_077979 - Class II

Cleavage pHMM score: -3.20

RODEO score: 0

Monoisotopic mass: 6503.4 Da

Molecular weight: 6507.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 6525.2 Da N = 1; 6543.2 Da N = 2; 6561.2 Da N = 3; 6579.3 Da N = 4; 6597.3 Da N = 5; 6615.3 Da N = 6; 6633.3 Da N = 7

allorf_077848_078039 - Class II

Cleavage pHMM score: -2.70

RODEO score: 0

Monoisotopic mass: 3371.7 Da

Molecular weight: 3374.0 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3392.0 Da N = 1

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism
RpoN	Regulator of nitrogen assimilation and virulence
RutR	Regulator of the pyrimidine and purine metabolism

NPDC021375.ctg-0023 - Region 1 - terpene-precursor

Download region GenBank file

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Location: 39,343 - 60,365 nt. (total: 21,023 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

CDS_08290: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000677.5	0.33	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000678.5	0.32	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000903.3	0.30	other (other)	fluorometabolite	Streptomyces cattleya
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0001911.3	0.30	terpene	raimonol	Streptomyces anulatus
BGC0000665.5	0.29	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0001594.3	0.29	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0001910.4	0.29	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0001126.4	0.28	other (other), terpene	12-epi-hapalindole J isonitrile, ambiguine A isonitrile, ambiguine B isonitrile, ambiguine C isonitrile, ambiguine D isonitrile, ambiguine E isonitrile, ambiguine K isonitrile, ambiguine L isonitrile, ambiguine I isonitrile, ambiguine J isonitrile	Fischerella ambigua UTEX 1903

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000677.5	0.33	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000678.5	0.32	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000903.3	0.30	other (other)	fluorometabolite	Streptomyces cattleya
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0001911.3	0.30	terpene	raimonol	Streptomyces anulatus
BGC0000665.5	0.29	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0001594.3	0.29	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0001910.4	0.29	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0001126.4	0.28	other (other), terpene	12-epi-hapalindole J isonitrile, ambiguine A isonitrile, ambiguine B isonitrile, ambiguine C isonitrile, ambiguine D isonitrile, ambiguine E isonitrile, ambiguine K isonitrile, ambiguine L isonitrile, ambiguine I isonitrile, ambiguine J isonitrile	Fischerella ambigua UTEX 1903

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

CDS_08290: PT_FPPS_like

Domain 1 (40 - 316): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.95 out of 32.93

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description

NPDC021375.ctg-0024 - Region 1 - lanthipeptide-class-iv

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Location: 55,245 - 91,318 nt. (total: 36,074 nt) Show pHMM detection rules used

lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene overview

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MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: back translocase hydrolase

CDS_08439: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

CDS_08464: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

Lyases: cyclase

CDS_08457: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

Ligases: ligase

CDS_08454: carboxylate-amine ligase

smcogs: SMCOG1165: carboxylate-amine ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002337.2	0.60	ribosomal	class IV lanthipeptide, SflA	Streptomyces sp. NRRL S-1022
BGC0000563.4	0.50	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.50	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000528.5	0.47	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002316.2	0.46	ribosomal	cebulantin	Saccharopolyspora cebuensis
BGC0000496.5	0.45	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000551.5	0.45	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000518.3	0.45	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000501.3	0.45	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000503.5	0.44	ribosomal	cinnamycin	Streptomyces cinnamoneus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002337.2	0.60	ribosomal	class IV lanthipeptide, SflA	Streptomyces sp. NRRL S-1022
BGC0000563.4	0.50	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.50	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000528.5	0.47	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002316.2	0.46	ribosomal	cebulantin	Saccharopolyspora cebuensis
BGC0000496.5	0.45	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000551.5	0.45	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000518.3	0.45	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000501.3	0.45	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000503.5	0.44	ribosomal	cinnamycin	Streptomyces cinnamoneus

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.51 out of 27.55

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.60 out of 21.55

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

Additional weak hits (9):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.88 out of 25.75

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.54 out of 26.85

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.19 out of 30.22

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.69 out of 21.55

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.22 out of 29.38

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.28 out of 29.51

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.79 out of 30.22

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 17.99 out of 26.33

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.07 out of 29.65

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Lanthipeptides

TFBS Finder

Core peptide predictions

No core peptides found.

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CRP	Cyclic AMP receptor protein
GnfM	Regulator of nitrogen-fixation genes
RpoN	Regulator of nitrogen assimilation and virulence

NPDC021375.ctg-0024 - Region 2 - hydrogen-cyanide

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Location: 117,556 - 130,696 nt. (total: 13,141 nt) Show pHMM detection rules used

hydrogen-cyanide: (Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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ClusterBlast

KnownClusterBlast

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TFBS Finder

Pfam domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase reductase

CDS_08495: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

CDS_08498: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

CDS_08500: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002345.2	0.54	other (other)	hydrogen cyanide	Pseudomonas fluorescens
BGC0001364.3	0.33	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0000603.5	0.32	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0002487.3	0.31	other (other)	staphylopine	Staphylococcus aureus subsp. aureus Mu50
BGC0000914.5	0.30	other (other)	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0000811.3	0.28	other (other)	fumigaclavine C	Aspergillus fumigatus Af293
BGC0002712.2	0.28	PKS	WS-5995 D, WS-5995 B, WS-5995 C, SEK 43	Streptomyces yanglinensis
BGC0000348.4	0.28	NRPS	ergovaline	Epichloe festucae var. lolii
BGC0001304.3	0.28	PKS	aflavarin	Aspergillus flavus NRRL3357
BGC0002070.3	0.27	PKS	SEK90, pentangumycin	Saccharothrix espanaensis DSM 44229

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002345.2	0.54	other (other)	hydrogen cyanide	Pseudomonas fluorescens
BGC0001364.3	0.33	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0000603.5	0.32	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0002487.3	0.31	other (other)	staphylopine	Staphylococcus aureus subsp. aureus Mu50
BGC0000914.5	0.30	other (other)	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0000811.3	0.28	other (other)	fumigaclavine C	Aspergillus fumigatus Af293
BGC0002712.2	0.28	PKS	WS-5995 D, WS-5995 B, WS-5995 C, SEK 43	Streptomyces yanglinensis
BGC0000348.4	0.28	NRPS	ergovaline	Epichloe festucae var. lolii
BGC0001304.3	0.28	PKS	aflavarin	Aspergillus flavus NRRL3357
BGC0002070.3	0.27	PKS	SEK90, pentangumycin	Saccharothrix espanaensis DSM 44229

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 22.13 out of 26.33

Confidence: medium

Additional weak hits (3):

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 19.95 out of 30.98

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.98 out of 29.25

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.64 out of 24.78

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator

NPDC021375.ctg-0026 - Region 1 - T2PKS

Download region GenBank file

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Location: 1 - 72,478 nt. (total: 72,478 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

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resistance

TTA codons

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Gene details

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Tailoring

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KnownClusterBlast

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TFBS Finder

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

CDS_08640: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

CDS_08646: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

CDS_08648: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

CDS_08656: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

CDS_08664: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: carboxylase kinase methyltransferase transferase

CDS_08645: glycerol kinase

smcogs: SMCOG1210: glycerol kinase

CDS_08661: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

CDS_08672: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

CDS_08674: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

CDS_08693: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: hydrolase

CDS_08659: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

Lyases: cyclase

CDS_08670: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

CDS_08671: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Isomerases: isomerase

CDS_08681: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

CDS_08667: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

CDS_08668: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

CDS_08682: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000272.3	0.73	PKS	spore pigment	Streptomyces collinus
BGC0000215.5	0.69	PKS	curamycin	Streptomyces cyaneus
BGC0000271.5	0.68	PKS	spore pigment	Streptomyces avermitilis
BGC0000234.5	0.60	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001833.4	0.58	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.58	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000261.5	0.58	PKS	R1128	Streptomyces sp. R1128
BGC0001197.5	0.57	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001513.3	0.55	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000275.4	0.55	PKS	tetracenomycin C	Streptomyces glaucescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000272.3	0.73	PKS	spore pigment	Streptomyces collinus
BGC0000215.5	0.69	PKS	curamycin	Streptomyces cyaneus
BGC0000271.5	0.68	PKS	spore pigment	Streptomyces avermitilis
BGC0000234.5	0.60	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001833.4	0.58	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.58	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000261.5	0.58	PKS	R1128	Streptomyces sp. R1128
BGC0001197.5	0.57	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001513.3	0.55	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000275.4	0.55	PKS	tetracenomycin C	Streptomyces glaucescens

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 30.74 out of 32.93

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.65 out of 18.46

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.88 out of 20.97

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.47 out of 27.04

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 29.86 out of 36.53

Confidence: medium

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 28.76 out of 32.38

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.11 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.65 out of 28.19

Confidence: medium

Additional weak hits (18):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.12 out of 21.84

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.14 out of 27.78

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.86 out of 26.33

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.78 out of 32.74

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.40 out of 18.57

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.62 out of 20.97

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.42 out of 39.62

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.79 out of 32.93

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.42 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.67 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.89 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.30 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.59 out of 26.06

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.21 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.13 out of 33.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.01 out of 28.19

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 22.47 out of 32.38

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

TFBS Finder

NRPS/PKS substrate predictions

CDS_08682: X

AMP-binding (42..444): X

nrpys: Sal

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: PLPAQGVLNK
Nearest Stachelhaus code(s):: Sal PLPAQGVLNK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 72478
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Product class(es):: pentangular polyphenol
tetracenomycin

CDS_08640: KR (Score: 75.4; E-value: 1.3e-23)
CDS_08661: MET C6|C8 (Score: 536.6; E-value: 4.5e-164)
CDS_08664: OXY (Score: 303.9; E-value: 5.1e-93)
CDS_08666: CYC C5-C18 (Score: 213.7; E-value: 1.5e-66)
CDS_08667: KS (Score: 710.2; E-value: 1.8e-216)
CDS_08668: CLF (Score: 532.2; E-value: 1.8e-162)
CDS_08669: ACP (Score: 67.5; E-value: 1.8e-21)
CDS_08670: CYC C9-C14 (Score: 240.7; E-value: 1.2e-74)
CDS_08671: CYC C4-C21/C2-C23|C2-C19 (Score: 154.4; E-value: 2e-48)

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CcpA	Catabolite control protein A
CsoR	Copper-responsive repressor
DasR	N-acetylglucosamine dependent repressor
DmdR1	Iron(II)-dependent repressor
RicR	Copper-responsive regulator
RpoN	Regulator of nitrogen assimilation and virulence
VqsM	Regulator of quorum-sensing signalling systems
ZuR variant 1	Zinc-responsive repressor

NPDC021375.ctg-0027 - Region 1 - NRPS

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Location: 83,286 - 106,810 nt. (total: 23,525 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

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NRPS/PKS modules

Pfam domains

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NRPS/PKS domains

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

CDS_08831: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Ligases: ligase

CDS_08846: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001641.4	0.66	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.66	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.65	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.65	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.65	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.64	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001641.4	0.66	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.66	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.65	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.65	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.65	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.64	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.86 out of 18.57

Confidence: medium

Additional weak hits (6):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.67 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.85 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.22 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.55 out of 27.78

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.03 out of 31.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.88 out of 30.25

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 83285 - 106810:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_08846: Ile

Search NORINE for peptide: strict or relaxed

AMP-binding (311..693): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAYFWGVTFK
Nearest Stachelhaus code(s):: Ile DAYFWGVTFK (85% 8Å match); Val DAYFWGVTFK (82% 8Å match); Ile or Val DAYFWGVTFK (82% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ToxT	Regulator of MSHA biosynthesis

NPDC021375.ctg-0029 - Region 1 - butyrolactone

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Location: 51,903 - 62,862 nt. (total: 10,960 nt) Show pHMM detection rules used

Region on contig edge.

butyrolactone: AfsA

Legend:

core biosynthetic genes

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TTA codons

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Select a gene to view the details available for it

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Pfam domains

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Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

CDS_08975: dihydropteridine reductase

smcogs: SMCOG1159: dihydropteridine reductase

Hydrolases: hydrolase

CDS_08980: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000848.5	0.76	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000849.4	0.56	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000850.5	0.54	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.48	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000941.3	0.38	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002535.2	0.35	NRPS	γ-poly-L-2,4-diaminobutyric acid	Streptomyces celluloflavus
BGC0002305.2	0.35	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001453.5	0.35	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0001458.4	0.34	other (aminocoumarin)	salinipostin G, Salinipostin G, Salinipostin A, Salinipostin B, Salinipostin C, Salinipostin D, Salinipostin E, Salinipostin F, Salinipostin H, Salinipostin I, Salinipostin J, Salinipostin K	Salinispora tropica CNB-440
BGC0001007.5	0.31	NRPS, PKS	lymphostin, neolymphostinol B, lymphostinol, neolymphostin b	Salinispora arenicola CNS-205

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000848.5	0.76	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000849.4	0.56	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000850.5	0.54	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.48	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000941.3	0.38	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002535.2	0.35	NRPS	γ-poly-L-2,4-diaminobutyric acid	Streptomyces celluloflavus
BGC0002305.2	0.35	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001453.5	0.35	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0001458.4	0.34	other (aminocoumarin)	salinipostin G, Salinipostin G, Salinipostin A, Salinipostin B, Salinipostin C, Salinipostin D, Salinipostin E, Salinipostin F, Salinipostin H, Salinipostin I, Salinipostin J, Salinipostin K	Salinispora tropica CNB-440
BGC0001007.5	0.31	NRPS, PKS	lymphostin, neolymphostinol B, lymphostinol, neolymphostin b	Salinispora arenicola CNS-205

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (8):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.25 out of 26.33

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.49 out of 30.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.40 out of 26.06

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.55 out of 20.97

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.54 out of 30.97

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.56 out of 28.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 17.96 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.82 out of 33.14

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description

NPDC021375.ctg-0039 - Region 1 - NRPS-like

Download region GenBank file

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Location: 8,819 - 33,430 nt. (total: 24,612 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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NRPS/PKS modules

Pfam domains

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NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase oxygenase

CDS_09382: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

CDS_09390: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

CDS_09393: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: halogenase

CDS_09389: flavin-dependent trp 5 halogenase

halogenases: flavin-dependent trp 5 halogenase
MITE: MITE0000030Halogenation (identity: 61.40%)
smcogs: SMCOG1119: halogenase

Hydrolases: esterase hydrolase

CDS_09378: isochorismatase

smcogs: SMCOG1027: isochorismatase

CDS_09381: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase

CDS_09392: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.63	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001641.4	0.63	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.63	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001825.4	0.62	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002075.3	0.62	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001135.5	0.62	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.63	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001641.4	0.63	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.63	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001825.4	0.62	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002075.3	0.62	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001135.5	0.62	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (5):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.29 out of 25.75

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.71 out of 33.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.86 out of 29.38

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.20 out of 32.93

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.99 out of 26.06

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 8818 - 33430:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Trp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_09392: Trp

Search NORINE for peptide: strict or relaxed

AMP-binding (14..406): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWVMTGVGK
Nearest Stachelhaus code(s):: Trp DAWVMTGVGK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description

NPDC021375.ctg-0043 - Region 1 - hglE-KS

Download region GenBank file

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Location: 1 - 21,849 nt. (total: 21,849 nt) Show pHMM detection rules used

Region on contig edge.

hglE-KS: (hglE or hglD)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

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TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acylase methyltransferase

CDS_09487: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

CDS_09490: methyltransferase

smcogs: SMCOG1089: methyltransferase

Lyases: dehydratase

CDS_09484: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

CDS_09486: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001268.4	0.60	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0000861.5	0.52	other (other)	eicosapentaenoic acid	Shewanella sp. BR-2
BGC0002648.2	0.52	PKS	eicosapentaenoic acid	Shewanella sp. N2AIL
BGC0000862.3	0.50	other (other)	eicosapentaenoic acid	Shewanella pneumatophori
BGC0000863.3	0.50	other (other)	eicosapentaenoic acid	Pseudoalteromonas sp. DS-12
BGC0000056.3	0.49	PKS	esperamicin	Actinomadura verrucosospora

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001268.4	0.60	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0000861.5	0.52	other (other)	eicosapentaenoic acid	Shewanella sp. BR-2
BGC0002648.2	0.52	PKS	eicosapentaenoic acid	Shewanella sp. N2AIL
BGC0000862.3	0.50	other (other)	eicosapentaenoic acid	Shewanella pneumatophori
BGC0000863.3	0.50	other (other)	eicosapentaenoic acid	Pseudoalteromonas sp. DS-12
BGC0000056.3	0.49	PKS	esperamicin	Actinomadura verrucosospora

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.99 out of 20.47

Confidence: medium

Additional weak hits (2):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 14.88 out of 27.78

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 21849:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CDS_09486: mal

PKS_AT (585..877): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; inactive: 62.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 67.4
Methoxymalonyl-CoA: 46.4
Methylmalonyl-CoA: 38.0
Ethylmalonyl-CoA: 21.3
Propionyl-CoA: 16.6
Isobutyryl-CoA: 13.1
Benzoyl-CoA: 11.1
fatty_acid: 8.0
2-Methylbutyryl-CoA: 6.4
CHC-CoA: 4.6
trans-1,2-CPDA: 0.0
inactive: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems