Streptomyces_odonnellii_NRRL_B-24891 - 38 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

LATD01000103.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	butyrolactone	2,137	13,126

LATD01000109.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 12.1	terpene-precursor	21,818	33,925

LATD01000111.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 15.1	terpene	4,643	31,251	High	hopene	terpene

LATD01000131.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 37.1	RRE-containing	22,748	39,148

LATD01000153.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 61.1	T3PKS,RiPP-like	1	23,578	Medium	perquinoline A/perquinoline B/perquinoline C	other:other

LATD01000155.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 63.1	T1PKS	1	31,601	Low	camporidine A/camporidine B	other:other+PKS

LATD01000157.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 65.1	furan	8,716	29,813

LATD01000016.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 68.1	T1PKS,hglE-KS	1	18,250

LATD01000164.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 73.1	terpene	1	3,494	High	geosmin	terpene:Sesquiterpene

LATD01000186.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 97.1	nucleoside	1	20,471	High	toyocamycin	other:other

LATD01000190.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 102.1	terpene	1	11,153

LATD01000195.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 107.1	T1PKS	1	44,619	Low	nystatin A1	PKS:Type I+saccharide:hybrid/tailoring

LATD01000202.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 116.1	lanthipeptide-class-i	1	13,690

LATD01000203.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 117.1	lassopeptide	3,662	17,219

LATD01000226.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 142.1	terpene	1	24,073

LATD01000229.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 145.1	ectoine	1	8,114
Region 145.2	butyrolactone	23,004	29,011

LATD01000231.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 148.1	NRPS	1	30,647

LATD01000024.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 157.1	T1PKS	1	78,961	Medium	nystatin A1	PKS:Type I+saccharide:hybrid/tailoring

LATD01000255.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 174.1	NRPS	1	27,525

LATD01000263.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 183.1	T2PKS	1	22,499

LATD01000027.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 190.1	terpene	19,849	40,181

LATD01000028.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 201.1	NI-siderophore	21,695	54,492

LATD01000283.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 205.1	T3PKS,melanin	1	23,191

LATD01000302.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 227.1	RiPP-like	1	7,766	Low	14-hydroxyisochainin	PKS:Modular type I

LATD01000309.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 234.1	terpene	1	5,032	Low	raimonol	terpene

LATD01000319.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 245.1	RRE-containing,azole-containing-RiPP	2,280	37,173

LATD01000339.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 267.1	NRPS	1	13,986	Low	scabichelin	NRPS:Type I

LATD01000393.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 327.1	terpene	1	9,976

LATD01000402.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 338.1	T1PKS	1	8,564

LATD01000439.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 378.1	ectoine	1	6,981	Medium	ectoine	other:other

LATD01000044.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 379.1	NRP-metallophore,NRPS	1	27,359	Medium	scabichelin	NRPS:Type I

LATD01000497.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 442.1	terpene	1	8,527	Low	raimonol	terpene

LATD01000500.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 447.1	RiPP-like	1	8,039

LATD01000054.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 490.1	T3PKS	9,945	50,928	High	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone/2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	PKS:Type III

LATD01000059.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 545.1	T1PKS,phenazine	1	48,671	Medium	streptazone E	PKS

LATD01000625.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 585.1	terpene	1	1,612	High	geosmin	terpene:Sesquiterpene

LATD01000089.1 (Streptomyces odonnellii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 637.1	lanthipeptide-class-iii	4,880	27,624	High	SapB	ribosomal:RiPP:Lanthipeptide

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	butyrolactone	2,137	13,126
Region 12.1	terpene-precursor	21,818	33,925
Region 15.1	terpene	4,643	31,251	High	hopene	terpene
Region 37.1	RRE-containing	22,748	39,148
Region 61.1	T3PKS,RiPP-like	1	23,578	Medium	perquinoline A/perquinoline B/perquinoline C	other:other
Region 63.1	T1PKS	1	31,601	Low	camporidine A/camporidine B	other:other+PKS
Region 65.1	furan	8,716	29,813
Region 68.1	T1PKS,hglE-KS	1	18,250
Region 73.1	terpene	1	3,494	High	geosmin	terpene:Sesquiterpene
Region 97.1	nucleoside	1	20,471	High	toyocamycin	other:other
Region 102.1	terpene	1	11,153
Region 107.1	T1PKS	1	44,619	Low	nystatin A1	PKS:Type I+saccharide:hybrid/tailoring
Region 116.1	lanthipeptide-class-i	1	13,690
Region 117.1	lassopeptide	3,662	17,219
Region 142.1	terpene	1	24,073
Region 145.1	ectoine	1	8,114
Region 145.2	butyrolactone	23,004	29,011
Region 148.1	NRPS	1	30,647
Region 157.1	T1PKS	1	78,961	Medium	nystatin A1	PKS:Type I+saccharide:hybrid/tailoring
Region 174.1	NRPS	1	27,525
Region 183.1	T2PKS	1	22,499
Region 190.1	terpene	19,849	40,181
Region 201.1	NI-siderophore	21,695	54,492
Region 205.1	T3PKS,melanin	1	23,191
Region 227.1	RiPP-like	1	7,766	Low	14-hydroxyisochainin	PKS:Modular type I
Region 234.1	terpene	1	5,032	Low	raimonol	terpene
Region 245.1	RRE-containing,azole-containing-RiPP	2,280	37,173
Region 267.1	NRPS	1	13,986	Low	scabichelin	NRPS:Type I
Region 327.1	terpene	1	9,976
Region 338.1	T1PKS	1	8,564
Region 378.1	ectoine	1	6,981	Medium	ectoine	other:other
Region 379.1	NRP-metallophore,NRPS	1	27,359	Medium	scabichelin	NRPS:Type I
Region 442.1	terpene	1	8,527	Low	raimonol	terpene
Region 447.1	RiPP-like	1	8,039
Region 490.1	T3PKS	9,945	50,928	High	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone/2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	PKS:Type III
Region 545.1	T1PKS,phenazine	1	48,671	Medium	streptazone E	PKS
Region 585.1	terpene	1	1,612	High	geosmin	terpene:Sesquiterpene
Region 637.1	lanthipeptide-class-iii	4,880	27,624	High	SapB	ribosomal:RiPP:Lanthipeptide

No secondary metabolite regions were found in these records:: LATD01000001.1 (Streptomyces odonnellii); LATD01000010.1 (Streptomyces odonnellii); LATD01000100.1 (Streptomyces odonnellii); LATD01000101.1 (Streptomyces odonnellii); LATD01000102.1 (Streptomyces odonnellii); LATD01000104.1 (Streptomyces odonnellii); LATD01000105.1 (Streptomyces odonnellii); LATD01000106.1 (Streptomyces odonnellii); LATD01000107.1 (Streptomyces odonnellii); LATD01000108.1 (Streptomyces odonnellii); LATD01000011.1 (Streptomyces odonnellii); LATD01000110.1 (Streptomyces odonnellii); LATD01000112.1 (Streptomyces odonnellii); LATD01000113.1 (Streptomyces odonnellii); LATD01000114.1 (Streptomyces odonnellii); LATD01000115.1 (Streptomyces odonnellii); LATD01000116.1 (Streptomyces odonnellii); LATD01000117.1 (Streptomyces odonnellii); LATD01000118.1 (Streptomyces odonnellii); LATD01000119.1 (Streptomyces odonnellii); LATD01000012.1 (Streptomyces odonnellii); LATD01000120.1 (Streptomyces odonnellii); LATD01000121.1 (Streptomyces odonnellii); LATD01000122.1 (Streptomyces odonnellii); LATD01000123.1 (Streptomyces odonnellii); LATD01000124.1 (Streptomyces odonnellii); LATD01000125.1 (Streptomyces odonnellii); LATD01000126.1 (Streptomyces odonnellii); LATD01000127.1 (Streptomyces odonnellii); LATD01000128.1 (Streptomyces odonnellii); LATD01000129.1 (Streptomyces odonnellii); LATD01000013.1 (Streptomyces odonnellii); LATD01000130.1 (Streptomyces odonnellii); LATD01000132.1 (Streptomyces odonnellii); LATD01000133.1 (Streptomyces odonnellii); LATD01000134.1 (Streptomyces odonnellii); LATD01000135.1 (Streptomyces odonnellii); LATD01000136.1 (Streptomyces odonnellii); LATD01000137.1 (Streptomyces odonnellii); LATD01000138.1 (Streptomyces odonnellii); LATD01000139.1 (Streptomyces odonnellii); LATD01000014.1 (Streptomyces odonnellii); LATD01000140.1 (Streptomyces odonnellii); LATD01000141.1 (Streptomyces odonnellii); LATD01000142.1 (Streptomyces odonnellii); LATD01000143.1 (Streptomyces odonnellii); LATD01000144.1 (Streptomyces odonnellii); LATD01000145.1 (Streptomyces odonnellii); LATD01000146.1 (Streptomyces odonnellii); LATD01000147.1 (Streptomyces odonnellii); LATD01000148.1 (Streptomyces odonnellii); LATD01000149.1 (Streptomyces odonnellii); LATD01000015.1 (Streptomyces odonnellii); LATD01000150.1 (Streptomyces odonnellii); LATD01000151.1 (Streptomyces odonnellii); LATD01000152.1 (Streptomyces odonnellii); LATD01000154.1 (Streptomyces odonnellii); LATD01000156.1 (Streptomyces odonnellii); LATD01000158.1 (Streptomyces odonnellii); LATD01000159.1 (Streptomyces odonnellii); LATD01000160.1 (Streptomyces odonnellii); LATD01000161.1 (Streptomyces odonnellii); LATD01000162.1 (Streptomyces odonnellii); LATD01000163.1 (Streptomyces odonnellii); LATD01000165.1 (Streptomyces odonnellii); LATD01000166.1 (Streptomyces odonnellii); LATD01000167.1 (Streptomyces odonnellii); LATD01000168.1 (Streptomyces odonnellii); LATD01000169.1 (Streptomyces odonnellii); LATD01000017.1 (Streptomyces odonnellii); LATD01000170.1 (Streptomyces odonnellii); LATD01000171.1 (Streptomyces odonnellii); LATD01000172.1 (Streptomyces odonnellii); LATD01000173.1 (Streptomyces odonnellii); LATD01000174.1 (Streptomyces odonnellii); LATD01000175.1 (Streptomyces odonnellii); LATD01000176.1 (Streptomyces odonnellii); LATD01000177.1 (Streptomyces odonnellii); LATD01000178.1 (Streptomyces odonnellii); LATD01000179.1 (Streptomyces odonnellii); LATD01000018.1 (Streptomyces odonnellii); LATD01000180.1 (Streptomyces odonnellii); LATD01000181.1 (Streptomyces odonnellii); LATD01000182.1 (Streptomyces odonnellii); LATD01000183.1 (Streptomyces odonnellii); LATD01000184.1 (Streptomyces odonnellii); LATD01000185.1 (Streptomyces odonnellii); LATD01000187.1 (Streptomyces odonnellii); LATD01000188.1 (Streptomyces odonnellii); LATD01000189.1 (Streptomyces odonnellii); LATD01000019.1 (Streptomyces odonnellii); LATD01000191.1 (Streptomyces odonnellii); LATD01000192.1 (Streptomyces odonnellii); LATD01000193.1 (Streptomyces odonnellii); LATD01000194.1 (Streptomyces odonnellii); LATD01000196.1 (Streptomyces odonnellii); LATD01000197.1 (Streptomyces odonnellii); LATD01000198.1 (Streptomyces odonnellii); LATD01000199.1 (Streptomyces odonnellii); LATD01000002.1 (Streptomyces odonnellii); LATD01000020.1 (Streptomyces odonnellii); LATD01000200.1 (Streptomyces odonnellii); LATD01000201.1 (Streptomyces odonnellii); LATD01000204.1 (Streptomyces odonnellii); LATD01000205.1 (Streptomyces odonnellii); LATD01000206.1 (Streptomyces odonnellii); LATD01000207.1 (Streptomyces odonnellii); LATD01000208.1 (Streptomyces odonnellii); LATD01000209.1 (Streptomyces odonnellii); LATD01000021.1 (Streptomyces odonnellii); LATD01000210.1 (Streptomyces odonnellii); LATD01000211.1 (Streptomyces odonnellii); LATD01000212.1 (Streptomyces odonnellii); LATD01000213.1 (Streptomyces odonnellii); LATD01000214.1 (Streptomyces odonnellii); LATD01000215.1 (Streptomyces odonnellii); LATD01000216.1 (Streptomyces odonnellii); LATD01000217.1 (Streptomyces odonnellii); LATD01000218.1 (Streptomyces odonnellii); LATD01000219.1 (Streptomyces odonnellii); LATD01000022.1 (Streptomyces odonnellii); LATD01000220.1 (Streptomyces odonnellii); LATD01000221.1 (Streptomyces odonnellii); LATD01000222.1 (Streptomyces odonnellii); LATD01000223.1 (Streptomyces odonnellii); LATD01000224.1 (Streptomyces odonnellii); LATD01000225.1 (Streptomyces odonnellii); LATD01000227.1 (Streptomyces odonnellii); LATD01000228.1 (Streptomyces odonnellii); LATD01000023.1 (Streptomyces odonnellii); LATD01000230.1 (Streptomyces odonnellii); LATD01000232.1 (Streptomyces odonnellii); LATD01000233.1 (Streptomyces odonnellii); LATD01000234.1 (Streptomyces odonnellii); LATD01000235.1 (Streptomyces odonnellii); LATD01000236.1 (Streptomyces odonnellii); LATD01000237.1 (Streptomyces odonnellii); LATD01000238.1 (Streptomyces odonnellii); LATD01000239.1 (Streptomyces odonnellii); LATD01000240.1 (Streptomyces odonnellii); LATD01000241.1 (Streptomyces odonnellii); LATD01000242.1 (Streptomyces odonnellii); LATD01000243.1 (Streptomyces odonnellii); LATD01000244.1 (Streptomyces odonnellii); LATD01000245.1 (Streptomyces odonnellii); LATD01000246.1 (Streptomyces odonnellii); LATD01000247.1 (Streptomyces odonnellii); LATD01000248.1 (Streptomyces odonnellii); LATD01000249.1 (Streptomyces odonnellii); LATD01000025.1 (Streptomyces odonnellii); LATD01000250.1 (Streptomyces odonnellii); LATD01000251.1 (Streptomyces odonnellii); LATD01000252.1 (Streptomyces odonnellii); LATD01000253.1 (Streptomyces odonnellii); LATD01000254.1 (Streptomyces odonnellii); LATD01000256.1 (Streptomyces odonnellii); LATD01000257.1 (Streptomyces odonnellii); LATD01000258.1 (Streptomyces odonnellii); LATD01000259.1 (Streptomyces odonnellii); LATD01000026.1 (Streptomyces odonnellii); LATD01000260.1 (Streptomyces odonnellii); LATD01000261.1 (Streptomyces odonnellii); LATD01000262.1 (Streptomyces odonnellii); LATD01000264.1 (Streptomyces odonnellii); LATD01000265.1 (Streptomyces odonnellii); LATD01000266.1 (Streptomyces odonnellii); LATD01000267.1 (Streptomyces odonnellii); LATD01000268.1 (Streptomyces odonnellii); LATD01000269.1 (Streptomyces odonnellii); LATD01000270.1 (Streptomyces odonnellii); LATD01000271.1 (Streptomyces odonnellii); LATD01000272.1 (Streptomyces odonnellii); LATD01000273.1 (Streptomyces odonnellii); LATD01000274.1 (Streptomyces odonnellii); LATD01000275.1 (Streptomyces odonnellii); LATD01000276.1 (Streptomyces odonnellii); LATD01000277.1 (Streptomyces odonnellii); LATD01000278.1 (Streptomyces odonnellii); LATD01000279.1 (Streptomyces odonnellii); LATD01000280.1 (Streptomyces odonnellii); LATD01000281.1 (Streptomyces odonnellii); LATD01000282.1 (Streptomyces odonnellii); LATD01000284.1 (Streptomyces odonnellii); LATD01000285.1 (Streptomyces odonnellii); LATD01000286.1 (Streptomyces odonnellii); LATD01000287.1 (Streptomyces odonnellii); LATD01000288.1 (Streptomyces odonnellii); LATD01000289.1 (Streptomyces odonnellii); LATD01000029.1 (Streptomyces odonnellii); LATD01000290.1 (Streptomyces odonnellii); LATD01000291.1 (Streptomyces odonnellii); LATD01000292.1 (Streptomyces odonnellii); LATD01000293.1 (Streptomyces odonnellii); LATD01000294.1 (Streptomyces odonnellii); LATD01000295.1 (Streptomyces odonnellii); LATD01000296.1 (Streptomyces odonnellii); LATD01000297.1 (Streptomyces odonnellii); LATD01000298.1 (Streptomyces odonnellii); LATD01000299.1 (Streptomyces odonnellii); LATD01000003.1 (Streptomyces odonnellii); LATD01000030.1 (Streptomyces odonnellii); LATD01000300.1 (Streptomyces odonnellii); LATD01000301.1 (Streptomyces odonnellii); LATD01000303.1 (Streptomyces odonnellii); LATD01000304.1 (Streptomyces odonnellii); LATD01000305.1 (Streptomyces odonnellii); LATD01000306.1 (Streptomyces odonnellii); LATD01000307.1 (Streptomyces odonnellii); LATD01000308.1 (Streptomyces odonnellii); LATD01000031.1 (Streptomyces odonnellii); LATD01000310.1 (Streptomyces odonnellii); LATD01000311.1 (Streptomyces odonnellii); LATD01000312.1 (Streptomyces odonnellii); LATD01000313.1 (Streptomyces odonnellii); LATD01000314.1 (Streptomyces odonnellii); LATD01000315.1 (Streptomyces odonnellii); LATD01000316.1 (Streptomyces odonnellii); LATD01000317.1 (Streptomyces odonnellii); LATD01000318.1 (Streptomyces odonnellii); LATD01000032.1 (Streptomyces odonnellii); LATD01000320.1 (Streptomyces odonnellii); LATD01000321.1 (Streptomyces odonnellii); LATD01000322.1 (Streptomyces odonnellii); LATD01000323.1 (Streptomyces odonnellii); LATD01000324.1 (Streptomyces odonnellii); LATD01000325.1 (Streptomyces odonnellii); LATD01000326.1 (Streptomyces odonnellii); LATD01000327.1 (Streptomyces odonnellii); LATD01000328.1 (Streptomyces odonnellii); LATD01000329.1 (Streptomyces odonnellii); LATD01000033.1 (Streptomyces odonnellii); LATD01000330.1 (Streptomyces odonnellii); LATD01000331.1 (Streptomyces odonnellii); LATD01000332.1 (Streptomyces odonnellii); LATD01000333.1 (Streptomyces odonnellii); LATD01000334.1 (Streptomyces odonnellii); LATD01000335.1 (Streptomyces odonnellii); LATD01000336.1 (Streptomyces odonnellii); LATD01000337.1 (Streptomyces odonnellii); LATD01000338.1 (Streptomyces odonnellii); LATD01000034.1 (Streptomyces odonnellii); LATD01000340.1 (Streptomyces odonnellii); LATD01000341.1 (Streptomyces odonnellii); LATD01000342.1 (Streptomyces odonnellii); LATD01000343.1 (Streptomyces odonnellii); LATD01000344.1 (Streptomyces odonnellii); LATD01000345.1 (Streptomyces odonnellii); LATD01000346.1 (Streptomyces odonnellii); LATD01000347.1 (Streptomyces odonnellii); LATD01000348.1 (Streptomyces odonnellii); LATD01000349.1 (Streptomyces odonnellii); LATD01000035.1 (Streptomyces odonnellii); LATD01000350.1 (Streptomyces odonnellii); LATD01000351.1 (Streptomyces odonnellii); LATD01000352.1 (Streptomyces odonnellii); LATD01000353.1 (Streptomyces odonnellii); LATD01000354.1 (Streptomyces odonnellii); LATD01000355.1 (Streptomyces odonnellii); LATD01000356.1 (Streptomyces odonnellii); LATD01000357.1 (Streptomyces odonnellii); LATD01000358.1 (Streptomyces odonnellii); LATD01000359.1 (Streptomyces odonnellii); LATD01000036.1 (Streptomyces odonnellii); LATD01000360.1 (Streptomyces odonnellii); LATD01000361.1 (Streptomyces odonnellii); LATD01000362.1 (Streptomyces odonnellii); LATD01000363.1 (Streptomyces odonnellii); LATD01000364.1 (Streptomyces odonnellii); LATD01000365.1 (Streptomyces odonnellii); LATD01000366.1 (Streptomyces odonnellii); LATD01000367.1 (Streptomyces odonnellii); LATD01000368.1 (Streptomyces odonnellii); LATD01000369.1 (Streptomyces odonnellii); LATD01000037.1 (Streptomyces odonnellii); LATD01000370.1 (Streptomyces odonnellii); LATD01000371.1 (Streptomyces odonnellii); LATD01000372.1 (Streptomyces odonnellii); LATD01000373.1 (Streptomyces odonnellii); LATD01000374.1 (Streptomyces odonnellii); LATD01000375.1 (Streptomyces odonnellii); LATD01000376.1 (Streptomyces odonnellii); LATD01000377.1 (Streptomyces odonnellii); LATD01000378.1 (Streptomyces odonnellii); LATD01000379.1 (Streptomyces odonnellii); LATD01000038.1 (Streptomyces odonnellii); LATD01000380.1 (Streptomyces odonnellii); LATD01000381.1 (Streptomyces odonnellii); LATD01000382.1 (Streptomyces odonnellii); LATD01000383.1 (Streptomyces odonnellii); LATD01000384.1 (Streptomyces odonnellii); LATD01000385.1 (Streptomyces odonnellii); LATD01000386.1 (Streptomyces odonnellii); LATD01000387.1 (Streptomyces odonnellii); LATD01000388.1 (Streptomyces odonnellii); LATD01000389.1 (Streptomyces odonnellii); LATD01000039.1 (Streptomyces odonnellii); LATD01000390.1 (Streptomyces odonnellii); LATD01000391.1 (Streptomyces odonnellii); LATD01000392.1 (Streptomyces odonnellii); LATD01000394.1 (Streptomyces odonnellii); LATD01000395.1 (Streptomyces odonnellii); LATD01000396.1 (Streptomyces odonnellii); LATD01000397.1 (Streptomyces odonnellii); LATD01000398.1 (Streptomyces odonnellii); LATD01000399.1 (Streptomyces odonnellii); LATD01000004.1 (Streptomyces odonnellii); LATD01000040.1 (Streptomyces odonnellii); LATD01000400.1 (Streptomyces odonnellii); LATD01000401.1 (Streptomyces odonnellii); LATD01000403.1 (Streptomyces odonnellii); LATD01000404.1 (Streptomyces odonnellii); LATD01000405.1 (Streptomyces odonnellii); LATD01000406.1 (Streptomyces odonnellii); LATD01000407.1 (Streptomyces odonnellii); LATD01000408.1 (Streptomyces odonnellii); LATD01000409.1 (Streptomyces odonnellii); LATD01000041.1 (Streptomyces odonnellii); LATD01000410.1 (Streptomyces odonnellii); LATD01000411.1 (Streptomyces odonnellii); LATD01000412.1 (Streptomyces odonnellii); LATD01000413.1 (Streptomyces odonnellii); LATD01000414.1 (Streptomyces odonnellii); LATD01000415.1 (Streptomyces odonnellii); LATD01000416.1 (Streptomyces odonnellii); LATD01000417.1 (Streptomyces odonnellii); LATD01000418.1 (Streptomyces odonnellii); LATD01000419.1 (Streptomyces odonnellii); LATD01000042.1 (Streptomyces odonnellii); LATD01000420.1 (Streptomyces odonnellii); LATD01000421.1 (Streptomyces odonnellii); LATD01000422.1 (Streptomyces odonnellii); LATD01000423.1 (Streptomyces odonnellii); LATD01000424.1 (Streptomyces odonnellii); LATD01000425.1 (Streptomyces odonnellii); LATD01000426.1 (Streptomyces odonnellii); LATD01000427.1 (Streptomyces odonnellii); LATD01000428.1 (Streptomyces odonnellii); LATD01000429.1 (Streptomyces odonnellii); LATD01000043.1 (Streptomyces odonnellii); LATD01000430.1 (Streptomyces odonnellii); LATD01000431.1 (Streptomyces odonnellii); LATD01000432.1 (Streptomyces odonnellii); LATD01000433.1 (Streptomyces odonnellii); LATD01000434.1 (Streptomyces odonnellii); LATD01000435.1 (Streptomyces odonnellii); LATD01000436.1 (Streptomyces odonnellii); LATD01000437.1 (Streptomyces odonnellii); LATD01000438.1 (Streptomyces odonnellii); LATD01000440.1 (Streptomyces odonnellii); LATD01000441.1 (Streptomyces odonnellii); LATD01000442.1 (Streptomyces odonnellii); LATD01000443.1 (Streptomyces odonnellii); LATD01000444.1 (Streptomyces odonnellii); LATD01000445.1 (Streptomyces odonnellii); LATD01000446.1 (Streptomyces odonnellii); LATD01000447.1 (Streptomyces odonnellii); LATD01000448.1 (Streptomyces odonnellii); LATD01000449.1 (Streptomyces odonnellii); LATD01000045.1 (Streptomyces odonnellii); LATD01000450.1 (Streptomyces odonnellii); LATD01000451.1 (Streptomyces odonnellii); LATD01000452.1 (Streptomyces odonnellii); LATD01000453.1 (Streptomyces odonnellii); LATD01000454.1 (Streptomyces odonnellii); LATD01000455.1 (Streptomyces odonnellii); LATD01000456.1 (Streptomyces odonnellii); LATD01000457.1 (Streptomyces odonnellii); LATD01000458.1 (Streptomyces odonnellii); LATD01000459.1 (Streptomyces odonnellii); LATD01000046.1 (Streptomyces odonnellii); LATD01000460.1 (Streptomyces odonnellii); LATD01000461.1 (Streptomyces odonnellii); LATD01000462.1 (Streptomyces odonnellii); LATD01000463.1 (Streptomyces odonnellii); LATD01000464.1 (Streptomyces odonnellii); LATD01000465.1 (Streptomyces odonnellii); LATD01000466.1 (Streptomyces odonnellii); LATD01000467.1 (Streptomyces odonnellii); LATD01000468.1 (Streptomyces odonnellii); LATD01000469.1 (Streptomyces odonnellii); LATD01000047.1 (Streptomyces odonnellii); LATD01000470.1 (Streptomyces odonnellii); LATD01000471.1 (Streptomyces odonnellii); LATD01000472.1 (Streptomyces odonnellii); LATD01000473.1 (Streptomyces odonnellii); LATD01000474.1 (Streptomyces odonnellii); LATD01000475.1 (Streptomyces odonnellii); LATD01000476.1 (Streptomyces odonnellii); LATD01000477.1 (Streptomyces odonnellii); LATD01000478.1 (Streptomyces odonnellii); LATD01000479.1 (Streptomyces odonnellii); LATD01000048.1 (Streptomyces odonnellii); LATD01000480.1 (Streptomyces odonnellii); LATD01000481.1 (Streptomyces odonnellii); LATD01000482.1 (Streptomyces odonnellii); LATD01000483.1 (Streptomyces odonnellii); LATD01000484.1 (Streptomyces odonnellii); LATD01000485.1 (Streptomyces odonnellii); LATD01000486.1 (Streptomyces odonnellii); LATD01000487.1 (Streptomyces odonnellii); LATD01000488.1 (Streptomyces odonnellii); LATD01000489.1 (Streptomyces odonnellii); LATD01000049.1 (Streptomyces odonnellii); LATD01000490.1 (Streptomyces odonnellii); LATD01000491.1 (Streptomyces odonnellii); LATD01000492.1 (Streptomyces odonnellii); LATD01000493.1 (Streptomyces odonnellii); LATD01000494.1 (Streptomyces odonnellii); LATD01000495.1 (Streptomyces odonnellii); LATD01000496.1 (Streptomyces odonnellii); LATD01000498.1 (Streptomyces odonnellii); LATD01000499.1 (Streptomyces odonnellii); LATD01000005.1 (Streptomyces odonnellii); LATD01000050.1 (Streptomyces odonnellii); LATD01000501.1 (Streptomyces odonnellii); LATD01000502.1 (Streptomyces odonnellii); LATD01000503.1 (Streptomyces odonnellii); LATD01000504.1 (Streptomyces odonnellii); LATD01000505.1 (Streptomyces odonnellii); LATD01000506.1 (Streptomyces odonnellii); LATD01000507.1 (Streptomyces odonnellii); LATD01000508.1 (Streptomyces odonnellii); LATD01000509.1 (Streptomyces odonnellii); LATD01000051.1 (Streptomyces odonnellii); LATD01000510.1 (Streptomyces odonnellii); LATD01000511.1 (Streptomyces odonnellii); LATD01000512.1 (Streptomyces odonnellii); LATD01000513.1 (Streptomyces odonnellii); LATD01000514.1 (Streptomyces odonnellii); LATD01000515.1 (Streptomyces odonnellii); LATD01000516.1 (Streptomyces odonnellii); LATD01000517.1 (Streptomyces odonnellii); LATD01000518.1 (Streptomyces odonnellii); LATD01000519.1 (Streptomyces odonnellii); LATD01000052.1 (Streptomyces odonnellii); LATD01000520.1 (Streptomyces odonnellii); LATD01000521.1 (Streptomyces odonnellii); LATD01000522.1 (Streptomyces odonnellii); LATD01000523.1 (Streptomyces odonnellii); LATD01000524.1 (Streptomyces odonnellii); LATD01000525.1 (Streptomyces odonnellii); LATD01000526.1 (Streptomyces odonnellii); LATD01000527.1 (Streptomyces odonnellii); LATD01000528.1 (Streptomyces odonnellii); LATD01000529.1 (Streptomyces odonnellii); LATD01000053.1 (Streptomyces odonnellii); LATD01000530.1 (Streptomyces odonnellii); LATD01000531.1 (Streptomyces odonnellii); LATD01000532.1 (Streptomyces odonnellii); LATD01000533.1 (Streptomyces odonnellii); LATD01000534.1 (Streptomyces odonnellii); LATD01000535.1 (Streptomyces odonnellii); LATD01000536.1 (Streptomyces odonnellii); LATD01000537.1 (Streptomyces odonnellii); LATD01000538.1 (Streptomyces odonnellii); LATD01000539.1 (Streptomyces odonnellii); LATD01000540.1 (Streptomyces odonnellii); LATD01000541.1 (Streptomyces odonnellii); LATD01000542.1 (Streptomyces odonnellii); LATD01000543.1 (Streptomyces odonnellii); LATD01000544.1 (Streptomyces odonnellii); LATD01000545.1 (Streptomyces odonnellii); LATD01000546.1 (Streptomyces odonnellii); LATD01000547.1 (Streptomyces odonnellii); LATD01000548.1 (Streptomyces odonnellii); LATD01000549.1 (Streptomyces odonnellii); LATD01000055.1 (Streptomyces odonnellii); LATD01000550.1 (Streptomyces odonnellii); LATD01000551.1 (Streptomyces odonnellii); LATD01000552.1 (Streptomyces odonnellii); LATD01000553.1 (Streptomyces odonnellii); LATD01000554.1 (Streptomyces odonnellii); LATD01000555.1 (Streptomyces odonnellii); LATD01000556.1 (Streptomyces odonnellii); LATD01000557.1 (Streptomyces odonnellii); LATD01000558.1 (Streptomyces odonnellii); LATD01000559.1 (Streptomyces odonnellii); LATD01000056.1 (Streptomyces odonnellii); LATD01000560.1 (Streptomyces odonnellii); LATD01000561.1 (Streptomyces odonnellii); LATD01000562.1 (Streptomyces odonnellii); LATD01000563.1 (Streptomyces odonnellii); LATD01000564.1 (Streptomyces odonnellii); LATD01000565.1 (Streptomyces odonnellii); LATD01000566.1 (Streptomyces odonnellii); LATD01000567.1 (Streptomyces odonnellii); LATD01000568.1 (Streptomyces odonnellii); LATD01000569.1 (Streptomyces odonnellii); LATD01000057.1 (Streptomyces odonnellii); LATD01000570.1 (Streptomyces odonnellii); LATD01000571.1 (Streptomyces odonnellii); LATD01000572.1 (Streptomyces odonnellii); LATD01000573.1 (Streptomyces odonnellii); LATD01000574.1 (Streptomyces odonnellii); LATD01000575.1 (Streptomyces odonnellii); LATD01000576.1 (Streptomyces odonnellii); LATD01000577.1 (Streptomyces odonnellii); LATD01000578.1 (Streptomyces odonnellii); LATD01000579.1 (Streptomyces odonnellii); LATD01000058.1 (Streptomyces odonnellii); LATD01000580.1 (Streptomyces odonnellii); LATD01000581.1 (Streptomyces odonnellii); LATD01000582.1 (Streptomyces odonnellii); LATD01000583.1 (Streptomyces odonnellii); LATD01000584.1 (Streptomyces odonnellii); LATD01000585.1 (Streptomyces odonnellii); LATD01000586.1 (Streptomyces odonnellii); LATD01000587.1 (Streptomyces odonnellii); LATD01000588.1 (Streptomyces odonnellii); LATD01000589.1 (Streptomyces odonnellii); LATD01000590.1 (Streptomyces odonnellii); LATD01000591.1 (Streptomyces odonnellii); LATD01000592.1 (Streptomyces odonnellii); LATD01000593.1 (Streptomyces odonnellii); LATD01000594.1 (Streptomyces odonnellii); LATD01000595.1 (Streptomyces odonnellii); LATD01000596.1 (Streptomyces odonnellii); LATD01000597.1 (Streptomyces odonnellii); LATD01000598.1 (Streptomyces odonnellii); LATD01000599.1 (Streptomyces odonnellii); LATD01000006.1 (Streptomyces odonnellii); LATD01000060.1 (Streptomyces odonnellii); LATD01000600.1 (Streptomyces odonnellii); LATD01000601.1 (Streptomyces odonnellii); LATD01000602.1 (Streptomyces odonnellii); LATD01000603.1 (Streptomyces odonnellii); LATD01000604.1 (Streptomyces odonnellii); LATD01000605.1 (Streptomyces odonnellii); LATD01000606.1 (Streptomyces odonnellii); LATD01000607.1 (Streptomyces odonnellii); LATD01000608.1 (Streptomyces odonnellii); LATD01000609.1 (Streptomyces odonnellii); LATD01000061.1 (Streptomyces odonnellii); LATD01000610.1 (Streptomyces odonnellii); LATD01000611.1 (Streptomyces odonnellii); LATD01000612.1 (Streptomyces odonnellii); LATD01000613.1 (Streptomyces odonnellii); LATD01000614.1 (Streptomyces odonnellii); LATD01000615.1 (Streptomyces odonnellii); LATD01000616.1 (Streptomyces odonnellii); LATD01000617.1 (Streptomyces odonnellii); LATD01000618.1 (Streptomyces odonnellii); LATD01000619.1 (Streptomyces odonnellii); LATD01000062.1 (Streptomyces odonnellii); LATD01000620.1 (Streptomyces odonnellii); LATD01000621.1 (Streptomyces odonnellii); LATD01000622.1 (Streptomyces odonnellii); LATD01000623.1 (Streptomyces odonnellii); LATD01000624.1 (Streptomyces odonnellii); LATD01000626.1 (Streptomyces odonnellii); LATD01000627.1 (Streptomyces odonnellii); LATD01000628.1 (Streptomyces odonnellii); LATD01000629.1 (Streptomyces odonnellii); LATD01000063.1 (Streptomyces odonnellii); LATD01000630.1 (Streptomyces odonnellii); LATD01000631.1 (Streptomyces odonnellii); LATD01000632.1 (Streptomyces odonnellii); LATD01000633.1 (Streptomyces odonnellii); LATD01000634.1 (Streptomyces odonnellii); LATD01000635.1 (Streptomyces odonnellii); LATD01000636.1 (Streptomyces odonnellii); LATD01000637.1 (Streptomyces odonnellii); LATD01000638.1 (Streptomyces odonnellii); LATD01000639.1 (Streptomyces odonnellii); LATD01000064.1 (Streptomyces odonnellii); LATD01000640.1 (Streptomyces odonnellii); LATD01000641.1 (Streptomyces odonnellii); LATD01000642.1 (Streptomyces odonnellii); LATD01000643.1 (Streptomyces odonnellii); LATD01000644.1 (Streptomyces odonnellii); LATD01000645.1 (Streptomyces odonnellii); LATD01000646.1 (Streptomyces odonnellii); LATD01000647.1 (Streptomyces odonnellii); LATD01000648.1 (Streptomyces odonnellii); LATD01000065.1 (Streptomyces odonnellii); LATD01000066.1 (Streptomyces odonnellii); LATD01000067.1 (Streptomyces odonnellii); LATD01000068.1 (Streptomyces odonnellii); LATD01000069.1 (Streptomyces odonnellii); LATD01000007.1 (Streptomyces odonnellii); LATD01000070.1 (Streptomyces odonnellii); LATD01000071.1 (Streptomyces odonnellii); LATD01000072.1 (Streptomyces odonnellii); LATD01000073.1 (Streptomyces odonnellii); LATD01000074.1 (Streptomyces odonnellii); LATD01000075.1 (Streptomyces odonnellii); LATD01000076.1 (Streptomyces odonnellii); LATD01000077.1 (Streptomyces odonnellii); LATD01000078.1 (Streptomyces odonnellii); LATD01000079.1 (Streptomyces odonnellii); LATD01000008.1 (Streptomyces odonnellii); LATD01000080.1 (Streptomyces odonnellii); LATD01000081.1 (Streptomyces odonnellii); LATD01000082.1 (Streptomyces odonnellii); LATD01000083.1 (Streptomyces odonnellii); LATD01000084.1 (Streptomyces odonnellii); LATD01000085.1 (Streptomyces odonnellii); LATD01000086.1 (Streptomyces odonnellii); LATD01000087.1 (Streptomyces odonnellii); LATD01000088.1 (Streptomyces odonnellii); LATD01000009.1 (Streptomyces odonnellii); LATD01000090.1 (Streptomyces odonnellii); LATD01000091.1 (Streptomyces odonnellii); LATD01000092.1 (Streptomyces odonnellii); LATD01000093.1 (Streptomyces odonnellii); LATD01000094.1 (Streptomyces odonnellii); LATD01000095.1 (Streptomyces odonnellii); LATD01000096.1 (Streptomyces odonnellii); LATD01000097.1 (Streptomyces odonnellii); LATD01000098.1 (Streptomyces odonnellii); LATD01000099.1 (Streptomyces odonnellii)

Compact view

LATD01000103.1 - Region 1 - butyrolactone

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Location: 2,137 - 13,126 nt. (total: 10,990 nt) Show pHMM detection rules used

Region on contig edge.

butyrolactone: AfsA

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: deacetylase hydrolase

ctg6_13: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

ctg6_8: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000849.4	0.76	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000848.5	0.75	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000850.5	0.63	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.46	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000914.5	0.35	other (other)	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0002571.2	0.32	NRPS	pyoverdine DC3000	Pseudomonas syringae pv. tomato str. DC3000
BGC0002285.2	0.31	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0000495.5	0.29	ribosomal	actagardine	Actinoplanes garbadinensis
BGC0001553.5	0.27	NRPS, PKS	clifednamide A	Streptomyces sp. JV178
BGC0000038.5	0.26	PKS	coelimycin P1	Streptomyces coelicolor A3(2)

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000849.4	0.76	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000848.5	0.75	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000850.5	0.63	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.46	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000914.5	0.35	other (other)	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0002571.2	0.32	NRPS	pyoverdine DC3000	Pseudomonas syringae pv. tomato str. DC3000
BGC0002285.2	0.31	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0000495.5	0.29	ribosomal	actagardine	Actinoplanes garbadinensis
BGC0001553.5	0.27	NRPS, PKS	clifednamide A	Streptomyces sp. JV178
BGC0000038.5	0.26	PKS	coelimycin P1	Streptomyces coelicolor A3(2)

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

Additional weak hits (1):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.18 out of 26.33

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator

LATD01000109.1 - Region 1 - terpene-precursor

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Download region SVG

Location: 21,818 - 33,925 nt. (total: 12,108 nt) Show pHMM detection rules used

Region on contig edge.

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

ctg12_32: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000948.5	0.45	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000657.5	0.44	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0000677.5	0.37	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001911.3	0.34	terpene	raimonol	Streptomyces anulatus
BGC0000678.5	0.33	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001910.4	0.32	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000665.5	0.32	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000643.3	0.32	terpene	carotenoid	Brevundimonas vesicularis
BGC0000664.5	0.32	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000948.5	0.45	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000657.5	0.44	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0000677.5	0.37	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001911.3	0.34	terpene	raimonol	Streptomyces anulatus
BGC0000678.5	0.33	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001910.4	0.32	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000665.5	0.32	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000643.3	0.32	terpene	carotenoid	Brevundimonas vesicularis
BGC0000664.5	0.32	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

ctg12_32: PT_FPPS_like

Domain 1 (70 - 352): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.35 out of 20.47

Confidence: strong

Additional weak hits (2):

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.38 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.68 out of 24.78

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems

LATD01000111.1 - Region 1 - terpene

Download region GenBank file

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Location: 4,643 - 31,251 nt. (total: 26,609 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

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transport-related genes

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resistance

TTA codons

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Gene overview

Tailoring

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ClusterBlast

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

ctg15_17: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

ctg15_9: dehydrogenase

smcogs: SMCOG1181: dehydrogenase

Transferases: aminotransferase transferase

ctg15_24: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

ctg15_8: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Lyases: dehydratase

ctg15_6: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase synthetase

ctg15_18: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

ctg15_23: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.81	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0002591.2	0.51	PKS, terpene	aurachin C, aurachin D, aurachin SS	Streptomyces sp.
BGC0000656.5	0.50	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0002162.3	0.49	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0002736.2	0.49	terpene	preaspterpenacid I	Aspergillus terreus NIH2624
BGC0002610.3	0.49	terpene	stellatic acid	Aspergillus stellatus
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0000630.3	0.49	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000651.5	0.49	terpene	KS-505a	Streptomyces argenteolus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.81	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0002591.2	0.51	PKS, terpene	aurachin C, aurachin D, aurachin SS	Streptomyces sp.
BGC0000656.5	0.50	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0002162.3	0.49	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0002736.2	0.49	terpene	preaspterpenacid I	Aspergillus terreus NIH2624
BGC0002610.3	0.49	terpene	stellatic acid	Aspergillus stellatus
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0000630.3	0.49	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000651.5	0.49	terpene	KS-505a	Streptomyces argenteolus

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

ctg15_14: PT_phytoene_like

Domain 1 (16 - 292): Prenyltransferase; Phytoene synthase like

Subtype: Hydroxysqualene synthase

Reactions:: PSPP → hydroxysqualene

ctg15_15: PT_phytoene_like

Domain 1 (16 - 304): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → PSPP; FPP → diapophytoene; GGPP → phytoene; PSPP → hydroxysqualene

ctg15_18: PT_FPPS_like

Domain 1 (62 - 353): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

ctg15_19: T2TS

Domain 1 (32 - 654): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.86 out of 21.84

Confidence: medium

Additional weak hits (4):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.15 out of 30.25

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 17.97 out of 36.54

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.51 out of 21.84

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.09 out of 30.98

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
AfsR	Pleiotropic regulatory for antibiotic production
MexT	Global virulence regulator

LATD01000131.1 - Region 1 - RRE-containing

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Location: 22,748 - 39,148 nt. (total: 16,401 nt) Show pHMM detection rules used

Region on contig edge.

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

Pfam domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002317.2	0.44	ribosomal	herbicolin O, mcceh252, pantocin A	Pantoea agglomerans
BGC0000585.5	0.40	ribosomal	microcin C7	Escherichia coli
BGC0001972.4	0.33	other (other)	toxoflavin, fervenulin	Streptomyces hiroshimensis
BGC0001548.4	0.31	ribosomal	citrulassin A	Streptomyces albulus
BGC0000016.4	0.29	other (other)	amphotericin B	Streptomyces nodosus
BGC0002755.2	0.23	NRPS	clovibactin	Eleftheria terrae P9846
BGC0000711.5	0.23	saccharide	neomycin	Streptomyces fradiae
BGC0001687.3	0.23	other (other)	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0000709.5	0.22	saccharide	neomycin	Streptomyces fradiae ATCC 10745 = DSM 40063
BGC0001335.5	0.21	other (other)	borregomycin A, borregomycin B, borregomycin C, borregomycin D	uncultured bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002317.2	0.44	ribosomal	herbicolin O, mcceh252, pantocin A	Pantoea agglomerans
BGC0000585.5	0.40	ribosomal	microcin C7	Escherichia coli
BGC0001972.4	0.33	other (other)	toxoflavin, fervenulin	Streptomyces hiroshimensis
BGC0001548.4	0.31	ribosomal	citrulassin A	Streptomyces albulus
BGC0000016.4	0.29	other (other)	amphotericin B	Streptomyces nodosus
BGC0002755.2	0.23	NRPS	clovibactin	Eleftheria terrae P9846
BGC0000711.5	0.23	saccharide	neomycin	Streptomyces fradiae
BGC0001687.3	0.23	other (other)	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0000709.5	0.22	saccharide	neomycin	Streptomyces fradiae ATCC 10745 = DSM 40063
BGC0001335.5	0.21	other (other)	borregomycin A, borregomycin B, borregomycin C, borregomycin D	uncultured bacterium

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.90 out of 18.57

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.82 out of 18.57

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.77 out of 28.19

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

RREFinder

TFBS Finder

RRE predictions

: RRE type: Pantocin_Microcin_RRE; Location: 13 - 104; Score: 76.8

TFBS definitions

Regulator	Description

LATD01000153.1 - Region 1 - RiPP-like,T3PKS

Download region GenBank file

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Location: 1 - 23,578 nt. (total: 23,578 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acyltransferase

ctg61_11: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

Lyases: hydratase

ctg61_1: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

ctg61_6: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: synthase

ctg61_3: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

ctg61_4: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001555.4	0.39	ribosomal	colicin V	Escherichia coli chi7122
BGC0002005.2	0.38	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000590.5	0.37	ribosomal	microcin N	Escherichia coli
BGC0000588.5	0.35	ribosomal	microcin L	Escherichia coli
BGC0002698.2	0.34	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002699.2	0.33	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000554.4	0.30	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000589.5	0.30	ribosomal	microcin M	Escherichia coli Nissle 1917
BGC0000519.4	0.29	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000587.5	0.28	ribosomal	microcin H47	Escherichia coli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002034.3	0.60	other (other)	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0002699.2	0.52	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0001555.4	0.52	ribosomal	colicin V	Escherichia coli chi7122
BGC0002698.2	0.52	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002005.2	0.51	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000590.5	0.50	ribosomal	microcin N	Escherichia coli
BGC0000588.5	0.49	ribosomal	microcin L	Escherichia coli
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000519.4	0.48	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000554.4	0.45	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (4):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.52 out of 18.57

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.20 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.16 out of 36.54

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.80 out of 28.19

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

ctg61_5: X

AMP-binding (106..311): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: AQTILI--YK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description

LATD01000155.1 - Region 1 - T1PKS

Download region GenBank file

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Location: 1 - 31,601 nt. (total: 31,601 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

ctg63_11: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

ctg63_13: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

ctg63_18: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

ctg63_9: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Ligases: synthase

ctg63_3: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002192.3	0.61	PKS	FR901512	fungal sp. No.14919
BGC0001164.3	0.61	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.61	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002192.3	0.61	PKS	FR901512	fungal sp. No.14919
BGC0001164.3	0.61	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.61	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.47 out of 27.78

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

Additional weak hits (5):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.08 out of 18.57

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.62 out of 25.75

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.10 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.52 out of 29.38

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.21 out of 26.33

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 31601:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg63_3: mmal

PKS_AT (579..876): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 213.7
Ethylmalonyl-CoA: 208.4
2-Methylbutyryl-CoA: 177.8
Methoxymalonyl-CoA: 169.2
trans-1,2-CPDA: 142.2
Propionyl-CoA: 136.5
CHC-CoA: 124.0
Malonyl-CoA: 114.8
Isobutyryl-CoA: 78.3
Benzoyl-CoA: 66.1
fatty_acid: 58.2
Acetyl-CoA: 54.6
3-Methylbutyryl-CoA: 37.6
inactive: 36.1

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
VqsM	Regulator of quorum-sensing signalling systems

LATD01000157.1 - Region 1 - furan

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Location: 8,716 - 29,813 nt. (total: 21,098 nt) Show pHMM detection rules used

Region on contig edge.

furan: (mmyO or AvrD)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

ctg65_29: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: methyltransferase

ctg65_39: methyltransferase

smcogs: SMCOG1248: methyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000866.5	0.46	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.3	0.45	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000565.5	0.42	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0001485.4	0.39	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0002138.2	0.39	PKS	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670
BGC0001810.3	0.39	PKS	trehangelin	Polymorphospora rubra
BGC0001336.5	0.38	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0000582.4	0.37	ribosomal	cypemycin	Streptomyces sp. OH-4156
BGC0000207.5	0.37	PKS	chartreusin	Streptomyces chartreusis
BGC0000678.5	0.37	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000866.5	0.46	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.3	0.45	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000565.5	0.42	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0001485.4	0.39	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0002138.2	0.39	PKS	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670
BGC0001810.3	0.39	PKS	trehangelin	Polymorphospora rubra
BGC0001336.5	0.38	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0000582.4	0.37	ribosomal	cypemycin	Streptomyces sp. OH-4156
BGC0000207.5	0.37	PKS	chartreusin	Streptomyces chartreusis
BGC0000678.5	0.37	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (9):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.54 out of 27.55

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.15 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.79 out of 26.06

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 18.32 out of 26.12

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 21.04 out of 36.54

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.03 out of 26.85

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.79 out of 30.22

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.80 out of 29.25

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description

LATD01000016.1 - Region 1 - T1PKS,hglE-KS

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Location: 1 - 18,250 nt. (total: 18,250 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
hglE-KS: (hglE or hglD)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

ctg68_6: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acylase

ctg68_1: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Ligases: synthase

ctg68_2: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	0.53	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.53	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.52	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.52	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002192.3	0.46	PKS	FR901512	fungal sp. No.14919
BGC0001160.5	0.45	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.45	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001254.3	0.45	PKS	ACT-Toxin II	Alternaria alternata
BGC0001268.4	0.43	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0000863.3	0.38	other (other)	eicosapentaenoic acid	Pseudoalteromonas sp. DS-12

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	0.60	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.60	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.59	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.59	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002192.3	0.56	PKS	FR901512	fungal sp. No.14919
BGC0001160.5	0.56	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.55	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001254.3	0.55	PKS	ACT-Toxin II	Alternaria alternata
BGC0001268.4	0.54	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0000863.3	0.51	other (other)	eicosapentaenoic acid	Pseudoalteromonas sp. DS-12

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.67 out of 19.26

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.12 out of 23.79

Confidence: medium

Additional weak hits (7):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.90 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.92 out of 29.38

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.56 out of 25.88

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.59 out of 27.55

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.53 out of 21.55

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.05 out of 27.78

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.19 out of 28.19

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 18250:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg68_1: pk

PKS_AT (634..855): pk

ATSignature: (unknown)

No matches above 50%

minowa: inactive

Prediction, score:

inactive: 12.7
3-Methylbutyryl-CoA: 11.4
Malonyl-CoA: 8.1
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg68_2: mal

PKS_AT (1234..1526): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 66.7%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 91.1
inactive: 39.6
Methoxymalonyl-CoA: 35.0
Methylmalonyl-CoA: 34.2
fatty_acid: 15.7
CHC-CoA: 13.0
2-Methylbutyryl-CoA: 12.1
Propionyl-CoA: 11.2
Benzoyl-CoA: 10.4
Isobutyryl-CoA: 9.7
Ethylmalonyl-CoA: 9.4
trans-1,2-CPDA: 8.9
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism

LATD01000164.1 - Region 1 - terpene

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Location: 1 - 3,494 nt. (total: 3,494 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

ctg73_3: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001181.4	0.84	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0000878.5	0.28	other (other)	puromycin	Streptomyces alboniger
BGC0002253.3	0.27	PKS	waikikiamide A, waikikiamide B, waikikiamide C, (+)-semivioxanthin, semivioxanthin	Aspergillus sp. FM242

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001181.4	0.84	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0000878.5	0.28	other (other)	puromycin	Streptomyces alboniger
BGC0002253.3	0.27	PKS	waikikiamide A, waikikiamide B, waikikiamide C, (+)-semivioxanthin, semivioxanthin	Aspergillus sp. FM242

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene		germacradienol	C15	C1-C10	OH

Genes with terpene domains:

ctg73_3: T1TS

Domain 1 (2 - 326): Type 1 terpene synthase

Subtype: Geosmin synthase, N terminal domain

Reactions:: FPP → germacradienol

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (1):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.73 out of 29.38

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate

TFBS definitions

Regulator	Description

LATD01000186.1 - Region 1 - nucleoside

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Location: 1 - 20,471 nt. (total: 20,471 nt) Show pHMM detection rules used

Region on contig edge.

nucleoside: (LipM or LipV or LipU or TunD or pur6 or pur10 or nikJ or nikO or truD)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

ctg97_20: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: glycosyltransferase

ctg97_10: Glycosylation

MITE: MITE0000018Glycosylation (identity: 61.50%)
smcogs: SMCOG1102: glycosyltransferase

Hydrolases: hydrolase

ctg97_1: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Lyases: lyase

ctg97_4: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000879.5	0.62	other (other)	toyocamycin, sangivamycin	Streptomyces rimosus
BGC0000881.3	0.60	other (other)	toyocamycin	Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001808.5	0.60	other (other)	toyocamycin	Streptomyces diastatochromogenes
BGC0001937.4	0.60	other (other)	tubercidin	Streptomyces tubercidicus
BGC0002354.4	0.53	other (other)	huimycin	Kutzneria albida DSM 43870
BGC0002246.3	0.43	terpene	naematolin	Hypholoma sublateritium FD-334 SS-4
BGC0000802.5	0.42	saccharide	succinoglycan	Sinorhizobium meliloti
BGC0002645.3	0.42	other (other)	fluopsin C	Pseudomonas aeruginosa PAO1
BGC0000875.4	0.41	other (nucleoside), saccharide	caprazamycin, caprazamycin aglycon	Streptomyces sp. MK730-62F2
BGC0002228.3	0.39	NRPS	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000879.5	0.62	other (other)	toyocamycin, sangivamycin	Streptomyces rimosus
BGC0000881.3	0.60	other (other)	toyocamycin	Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001808.5	0.60	other (other)	toyocamycin	Streptomyces diastatochromogenes
BGC0001937.4	0.60	other (other)	tubercidin	Streptomyces tubercidicus
BGC0002354.4	0.53	other (other)	huimycin	Kutzneria albida DSM 43870
BGC0002246.3	0.43	terpene	naematolin	Hypholoma sublateritium FD-334 SS-4
BGC0000802.5	0.42	saccharide	succinoglycan	Sinorhizobium meliloti
BGC0002645.3	0.42	other (other)	fluopsin C	Pseudomonas aeruginosa PAO1
BGC0000875.4	0.41	other (nucleoside), saccharide	caprazamycin, caprazamycin aglycon	Streptomyces sp. MK730-62F2
BGC0002228.3	0.39	NRPS	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.70 out of 23.79

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.15 out of 29.72

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

Additional weak hits (8):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.40 out of 30.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.64 out of 27.78

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.18 out of 25.75

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.47 out of 27.55

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.56 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.39 out of 29.38

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.25 out of 27.18

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.52 out of 28.19

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
IolR	Regulator of the inositol catabolism
NtrC	Nitrogen regulatory protein C

LATD01000190.1 - Region 1 - terpene

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Location: 1 - 11,153 nt. (total: 11,153 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Pfam domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

ctg102_2: methyltransferase

smcogs: SMCOG1089: methyltransferase

Lyases: cyclase

ctg102_1: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000658.3	0.86	terpene	2-methylisoborneol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000659.3	0.79	terpene	2-methylisoborneol	Saccharopolyspora erythraea NRRL 2338
BGC0000657.5	0.55	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0000453.5	0.25	NRPS	valinomycin	Streptomyces tsusimaensis
BGC0001580.3	0.24	PKS	ebelactone	Kitasatospora aburaviensis
BGC0002666.2	0.23	NRPS, other (other)	Legonmycin A, Legonmycin B, Legonindolizine A, Legonindolizine B	Streptomyces sp. MA37
BGC0001335.5	0.22	other (other)	borregomycin A, borregomycin B, borregomycin C, borregomycin D	uncultured bacterium
BGC0002343.3	0.21	other (other), ribosomal	ammosester A, ammosester B, ammosester C, ammosamaic acid cogener	Streptomyces uncialis
BGC0000651.5	0.21	terpene	KS-505a	Streptomyces argenteolus
BGC0002805.2	0.21	other (other)	Azodyrecin A, Azodyrecin B, Azodyrecin C	Streptomyces mirabilis strain P8-A

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000658.3	0.86	terpene	2-methylisoborneol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000659.3	0.79	terpene	2-methylisoborneol	Saccharopolyspora erythraea NRRL 2338
BGC0000657.5	0.55	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0000453.5	0.25	NRPS	valinomycin	Streptomyces tsusimaensis
BGC0001580.3	0.24	PKS	ebelactone	Kitasatospora aburaviensis
BGC0002666.2	0.23	NRPS, other (other)	Legonmycin A, Legonmycin B, Legonindolizine A, Legonindolizine B	Streptomyces sp. MA37
BGC0001335.5	0.22	other (other)	borregomycin A, borregomycin B, borregomycin C, borregomycin D	uncultured bacterium
BGC0002343.3	0.21	other (other), ribosomal	ammosester A, ammosester B, ammosester C, ammosamaic acid cogener	Streptomyces uncialis
BGC0000651.5	0.21	terpene	KS-505a	Streptomyces argenteolus
BGC0002805.2	0.21	other (other)	Azodyrecin A, Azodyrecin B, Azodyrecin C	Streptomyces mirabilis strain P8-A

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
monoterpene		2-methylisoborneol	C11	C1-C6	OH
monoterpene		2-methylenebornane	C11	C1-C6	none

Genes with terpene domains:

ctg102_1: T1TS

Domain 1 (17 - 377): Type 1 terpene synthase

Subtype: 2-Methylisoborneol synthase type

Reactions:: 2-MeGPP → 2-methylisoborneol; 2-MeGPP → 2-methylenebornane

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (1):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.38 out of 36.53

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Terpene

TFBS Finder

Glossary

Acronym	Full name
2-MeGPP	2-methylgeranyl diphosphate

TFBS definitions

Regulator	Description

LATD01000195.1 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 44,619 nt. (total: 44,619 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase

ctg107_4: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1060: 4'-phosphopantetheinyl transferase

Lyases: dehydratase

ctg107_8: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

ctg107_10: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ctg107_9: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	0.74	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002192.3	0.61	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	0.74	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002192.3	0.61	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.22 out of 30.25

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.87 out of 24.78

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.33 out of 24.78

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 44619:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ccmal - ohmal - Me-ohmal - ohmal - ohmal - ohmal) + (redmal)
Non-colinear ordering:: ctg107_9 + ctg107_10

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg107_9: mal - mal - mmal - mal - mal - mal

PKS_AT (562..860): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 214.4
inactive: 94.0
Methoxymalonyl-CoA: 70.2
Methylmalonyl-CoA: 54.4
Propionyl-CoA: 40.4
Ethylmalonyl-CoA: 28.9
Isobutyryl-CoA: 26.4
Benzoyl-CoA: 22.1
Acetyl-CoA: 21.1
trans-1,2-CPDA: 15.0
CHC-CoA: 14.0
fatty_acid: 13.5
2-Methylbutyryl-CoA: 9.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (2296..2595): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 232.9
inactive: 102.6
Methoxymalonyl-CoA: 65.4
Methylmalonyl-CoA: 57.8
Propionyl-CoA: 38.1
Acetyl-CoA: 29.9
Ethylmalonyl-CoA: 27.1
Isobutyryl-CoA: 25.5
Benzoyl-CoA: 22.4
2-Methylbutyryl-CoA: 21.4
fatty_acid: 18.0
trans-1,2-CPDA: 17.1
CHC-CoA: 15.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (3846..4143): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.4
Ethylmalonyl-CoA: 199.5
Methoxymalonyl-CoA: 175.1
2-Methylbutyryl-CoA: 134.2
trans-1,2-CPDA: 128.4
Propionyl-CoA: 105.6
CHC-CoA: 98.8
Isobutyryl-CoA: 88.4
Malonyl-CoA: 82.6
Benzoyl-CoA: 69.3
3-Methylbutyryl-CoA: 42.0
fatty_acid: 40.8
Acetyl-CoA: 38.8
inactive: 12.5

PKS_AT (5385..5685): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 237.3
inactive: 116.5
Methoxymalonyl-CoA: 69.1
Methylmalonyl-CoA: 57.4
Propionyl-CoA: 46.7
Isobutyryl-CoA: 27.9
2-Methylbutyryl-CoA: 26.7
Acetyl-CoA: 23.0
Benzoyl-CoA: 22.2
Ethylmalonyl-CoA: 21.2
fatty_acid: 12.8
trans-1,2-CPDA: 8.8
CHC-CoA: 8.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (6923..7218): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 235.0
inactive: 111.4
Methoxymalonyl-CoA: 58.8
Methylmalonyl-CoA: 55.5
Propionyl-CoA: 33.5
Isobutyryl-CoA: 23.3
2-Methylbutyryl-CoA: 19.2
Ethylmalonyl-CoA: 19.0
Acetyl-CoA: 17.9
Benzoyl-CoA: 16.8
CHC-CoA: 10.8
trans-1,2-CPDA: 10.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (8489..8782): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 217.9
inactive: 104.8
Methylmalonyl-CoA: 57.5
Methoxymalonyl-CoA: 55.5
Propionyl-CoA: 32.2
Isobutyryl-CoA: 25.7
Benzoyl-CoA: 23.9
Acetyl-CoA: 23.6
Ethylmalonyl-CoA: 21.4
trans-1,2-CPDA: 15.2
fatty_acid: 12.1
CHC-CoA: 12.1
2-Methylbutyryl-CoA: 8.8
3-Methylbutyryl-CoA: 0.0

ctg107_10: mal

PKS_AT (575..865): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 237.1
inactive: 109.1
Methoxymalonyl-CoA: 64.6
Methylmalonyl-CoA: 57.0
Propionyl-CoA: 41.1
Isobutyryl-CoA: 27.4
Ethylmalonyl-CoA: 26.7
2-Methylbutyryl-CoA: 26.0
Acetyl-CoA: 19.4
Benzoyl-CoA: 18.3
CHC-CoA: 11.8
trans-1,2-CPDA: 8.5
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description

LATD01000202.1 - Region 1 - lanthipeptide-class-i

Download region GenBank file

Download region SVG

Location: 1 - 13,690 nt. (total: 13,690 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase dehydratase

ctg116_12: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

ctg116_13: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

ctg116_5: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.75	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0001289.5	0.49	ribosomal	penisin	Paenibacillus ehimensis
BGC0002635.2	0.44	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000542.3	0.44	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.44	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0001727.3	0.40	ribosomal	paenilan	Paenibacillus polymyxa E681
BGC0000518.3	0.40	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000529.5	0.36	ribosomal	microbisporicin A2	Microbispora corallina
BGC0001695.5	0.29	NRPS	neoantimycin	Streptomyces conglobatus
BGC0001435.4	0.28	NRPS, PKS	ikarugamycin	Streptomyces sp. ZJ306

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.75	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0001289.5	0.49	ribosomal	penisin	Paenibacillus ehimensis
BGC0002635.2	0.44	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000542.3	0.44	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.44	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0001727.3	0.40	ribosomal	paenilan	Paenibacillus polymyxa E681
BGC0000518.3	0.40	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000529.5	0.36	ribosomal	microbisporicin A2	Microbispora corallina
BGC0001695.5	0.29	NRPS	neoantimycin	Streptomyces conglobatus
BGC0001435.4	0.28	NRPS, PKS	ikarugamycin	Streptomyces sp. ZJ306

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for ctg116_12

ctg116_11

Leader:

MTVQMERPVAPVRPATEEQDLTGFDLDITIVEGGPAAD

Core:

QLIRLTSDGCNSTCATACVSCP

Core with dehydrations:

QLIRLDhbDhaDGCysNDhaDhbCysADhbACysVDhaCysP

antiSMASH-DB 4.0 matches for ctg116_11

100.0%

NZ_NDXL01000003.1and 1 other:

NZ_NDXL01000003.1 Lanthipeptides: B7024_RS36425_lanthipeptide

Lanthipeptides: B7024_RS36425_lanthipeptide

1

QLIRLTSDGCNSTCATACVSCP

22

QLIRLTSDGCNSTCATACVSCP

1

QLIRLTSDGCNSTCATACVSCP

22

95.5%

NC_016109.1and 4 others:

NC_016109.1 Lanthipeptides: KSE_RS29105_lanthipeptideNZ_AP023440.1 Lanthipeptides: IGS71_RS16730_lanthipeptideNZ_AP023440.1 Lanthipeptides: IGS71_RS16730_lanthipeptideNZ_AP023440.1 Lanthipeptides: IGS71_RS16730_lanthipeptide

Lanthipeptides: KSE_RS29105_lanthipeptide

1

QLIRLTSDGCNSTCATACVSCP

22

QLIRLT+DGCNSTCATACVSCP

1

QLIRLTNDGCNSTCATACVSCP

22

95.5%

NZ_CP021121.1and 1 other:

NZ_CP021121.1 Lanthipeptides: CAG99_RS19010_lanthipeptide

Lanthipeptides: CAG99_RS19010_lanthipeptide

1

QLIRLTSDGCNSTCATACVSCP

22

QLIRLT DGCNSTCATACVSCP

1

QLIRLTGDGCNSTCATACVSCP

22

with 174 more sequence matches

Only the first 10 are displayed here.

95.5%

NZ_CP031264.1and 1 other:

NZ_CP031264.1 Lanthipeptides: C7M71_RS22650_lanthipeptide

Lanthipeptides: C7M71_RS22650_lanthipeptide

1

QLIRLTSDGCNSTCATACVSCP

22

QLIRLT DGCNSTCATACVSCP

1

QLIRLTDDGCNSTCATACVSCP

22

90.9%

NZ_JACERG010000017.1and 1 other:

NZ_JACERG010000017.1 Lanthipeptides: H1X69_RS24645_lanthipeptide

Lanthipeptides: H1X69_RS24645_lanthipeptide

1

QLIRLTSDGCNSTCATACVSCP

22

QLIRLT+DGCNSTCA+ACVSCP

1

QLIRLTNDGCNSTCASACVSCP

22

86.4%

NZ_CP045572.1and 1 other:

NZ_CP045572.1 Lanthipeptides: GBF35_RS16225_lanthipeptide

Lanthipeptides: GBF35_RS16225_lanthipeptide

1

QLIRLTSDGCNSTCATACVSCP

22

QLIR+T DGCNSTCATAC SCP

1

QLIRMTDDGCNSTCATACNSCP

22

82.6%

NZ_BCBX01000061.1and 1 other:

NZ_BCBX01000061.1 Lanthipeptides: AP234_RS35640_lanthipeptide

Lanthipeptides: AP234_RS35640_lanthipeptide

1

QLIRLTSDGCNSTCATACVSC

21

QLIR+T DGCNSTCATACVSC

1

QLIRMTDDGCNSTCATACVSC

21

82.6%

NZ_CP119143.1and 1 other:

NZ_CP119143.1 Lanthipeptides: PYR72_RS32440_lanthipeptide

Lanthipeptides: PYR72_RS32440_lanthipeptide

1

QLIRLTSDGCNSTCATACVSCP

22

QLIR+T DGCNSTCATAC SCP

1

QLIRMTDDGCNSTCATACTSCP

22

78.3%

NZ_CP045572.1and 1 other:

NZ_CP045572.1 Lanthipeptides: GBF35_RS37485_lanthipeptide

Lanthipeptides: GBF35_RS37485_lanthipeptide

1

QLIRLTSDGCNSTCATACVSC

21

QLIR+T DGCNSTC TACVSC

1

QLIRMTDDGCNSTCGTACVSC

21

77.3%

NZ_CP026652.1and 1 other:

NZ_CP026652.1 Lanthipeptides: C4B68_RS00400_lanthipeptide

Lanthipeptides: C4B68_RS00400_lanthipeptide

1

QLIRLTSDGCNSTCATACVSCP

22

QLIRLT+DGC STC +AC SCP

1

QLIRLTNDGCGSTCQSACTSCP

22

60.9%

NC_007777.1and 1 other:

NC_007777.1 Lanthipeptides: FRANCCI3_RS10225_lanthipeptide

Lanthipeptides: FRANCCI3_RS10225_lanthipeptide

1

QLIRLTSDGCNSTCATAC-VSCP

22

+LIR+T DGC +TC TAC +CP

1

RLIRMTDDGCGTTCETACSTTCP

23

59.1%

NZ_AZVD01000043.1and 3 others:

NZ_AZVD01000043.1 Lanthipeptides: K389_RS1000000127440_lanthipeptideNZ_KB898438.1 Lanthipeptides: D462_RS1000000129145_lanthipeptideNZ_KB898438.1 Lanthipeptides: D462_RS1000000129145_lanthipeptide

Lanthipeptides: K389_RS1000000127440_lanthipeptide

2

LIRLTSDGCNSTCATACVSCP

22

L+R TSD C TCA+AC SC

1

LLRSTSDNCGGTCASACTSCK

21

59.1%

NZ_CP061725.1and 1 other:

NZ_CP061725.1 Lanthipeptides: ID554_RS13020_lanthipeptide

Lanthipeptides: ID554_RS13020_lanthipeptide

2

LIRLTSDGCNSTCATACVSCP

22

L+R TSD C TCA+AC SC

1

LMRSTSDNCGKTCASACTSCK

21

Lanthipeptide(s) for ctg116_14

ctg116_11

Leader:

MTVQMERPVAPVRPATEEQDLTGFDLDITIVEGGPAAD

Core:

QLIRLTSDGCNSTCATACVSCP

Core with dehydrations:

QLIRLDhbDhaDGCysNDhaDhbCysADhbACysVDhaCysP

antiSMASH-DB 4.0 matches for ctg116_11

100.0%

NZ_NDXL01000003.1and 1 other:

NZ_NDXL01000003.1 Lanthipeptides: B7024_RS36425_lanthipeptide

Lanthipeptides: B7024_RS36425_lanthipeptide

1

QLIRLTSDGCNSTCATACVSCP

22

QLIRLTSDGCNSTCATACVSCP

1

QLIRLTSDGCNSTCATACVSCP

22

95.5%

NC_016109.1and 4 others:

NC_016109.1 Lanthipeptides: KSE_RS29105_lanthipeptideNZ_AP023440.1 Lanthipeptides: IGS71_RS16730_lanthipeptideNZ_AP023440.1 Lanthipeptides: IGS71_RS16730_lanthipeptideNZ_AP023440.1 Lanthipeptides: IGS71_RS16730_lanthipeptide

Lanthipeptides: KSE_RS29105_lanthipeptide

1

QLIRLTSDGCNSTCATACVSCP

22

QLIRLT+DGCNSTCATACVSCP

1

QLIRLTNDGCNSTCATACVSCP

22

95.5%

NZ_CP021121.1and 1 other:

NZ_CP021121.1 Lanthipeptides: CAG99_RS19010_lanthipeptide

Lanthipeptides: CAG99_RS19010_lanthipeptide

1

QLIRLTSDGCNSTCATACVSCP

22

QLIRLT DGCNSTCATACVSCP

1

QLIRLTGDGCNSTCATACVSCP

22

with 174 more sequence matches

Only the first 10 are displayed here.

95.5%

NZ_CP031264.1and 1 other:

NZ_CP031264.1 Lanthipeptides: C7M71_RS22650_lanthipeptide

Lanthipeptides: C7M71_RS22650_lanthipeptide

1

QLIRLTSDGCNSTCATACVSCP

22

QLIRLT DGCNSTCATACVSCP

1

QLIRLTDDGCNSTCATACVSCP

22

90.9%

NZ_JACERG010000017.1and 1 other:

NZ_JACERG010000017.1 Lanthipeptides: H1X69_RS24645_lanthipeptide

Lanthipeptides: H1X69_RS24645_lanthipeptide

1

QLIRLTSDGCNSTCATACVSCP

22

QLIRLT+DGCNSTCA+ACVSCP

1

QLIRLTNDGCNSTCASACVSCP

22

86.4%

NZ_CP045572.1and 1 other:

NZ_CP045572.1 Lanthipeptides: GBF35_RS16225_lanthipeptide

Lanthipeptides: GBF35_RS16225_lanthipeptide

1

QLIRLTSDGCNSTCATACVSCP

22

QLIR+T DGCNSTCATAC SCP

1

QLIRMTDDGCNSTCATACNSCP

22

82.6%

NZ_BCBX01000061.1and 1 other:

NZ_BCBX01000061.1 Lanthipeptides: AP234_RS35640_lanthipeptide

Lanthipeptides: AP234_RS35640_lanthipeptide

1

QLIRLTSDGCNSTCATACVSC

21

QLIR+T DGCNSTCATACVSC

1

QLIRMTDDGCNSTCATACVSC

21

82.6%

NZ_CP119143.1and 1 other:

NZ_CP119143.1 Lanthipeptides: PYR72_RS32440_lanthipeptide

Lanthipeptides: PYR72_RS32440_lanthipeptide

1

QLIRLTSDGCNSTCATACVSCP

22

QLIR+T DGCNSTCATAC SCP

1

QLIRMTDDGCNSTCATACTSCP

22

78.3%

NZ_CP045572.1and 1 other:

NZ_CP045572.1 Lanthipeptides: GBF35_RS37485_lanthipeptide

Lanthipeptides: GBF35_RS37485_lanthipeptide

1

QLIRLTSDGCNSTCATACVSC

21

QLIR+T DGCNSTC TACVSC

1

QLIRMTDDGCNSTCGTACVSC

21

77.3%

NZ_CP026652.1and 1 other:

NZ_CP026652.1 Lanthipeptides: C4B68_RS00400_lanthipeptide

Lanthipeptides: C4B68_RS00400_lanthipeptide

1

QLIRLTSDGCNSTCATACVSCP

22

QLIRLT+DGC STC +AC SCP

1

QLIRLTNDGCGSTCQSACTSCP

22

60.9%

NC_007777.1and 1 other:

NC_007777.1 Lanthipeptides: FRANCCI3_RS10225_lanthipeptide

Lanthipeptides: FRANCCI3_RS10225_lanthipeptide

1

QLIRLTSDGCNSTCATAC-VSCP

22

+LIR+T DGC +TC TAC +CP

1

RLIRMTDDGCGTTCETACSTTCP

23

59.1%

NZ_AZVD01000043.1and 3 others:

NZ_AZVD01000043.1 Lanthipeptides: K389_RS1000000127440_lanthipeptideNZ_KB898438.1 Lanthipeptides: D462_RS1000000129145_lanthipeptideNZ_KB898438.1 Lanthipeptides: D462_RS1000000129145_lanthipeptide

Lanthipeptides: K389_RS1000000127440_lanthipeptide

2

LIRLTSDGCNSTCATACVSCP

22

L+R TSD C TCA+AC SC

1

LLRSTSDNCGGTCASACTSCK

21

59.1%

NZ_CP061725.1and 1 other:

NZ_CP061725.1 Lanthipeptides: ID554_RS13020_lanthipeptide

Lanthipeptides: ID554_RS13020_lanthipeptide

2

LIRLTSDGCNSTCATACVSCP

22

L+R TSD C TCA+AC SC

1

LMRSTSDNCGKTCASACTSCK

21

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (4):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.27 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.10 out of 29.38

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.00 out of 20.01

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

ctg116_11 - Class I

Cleavage pHMM score: -1.70

RODEO score: 24

Monoisotopic mass: 2134.0 Da

Molecular weight: 2135.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 2153.5 Da N = 1; 2171.5 Da N = 2

ctg116_11 - Class I

Cleavage pHMM score: -1.70

RODEO score: 24

Monoisotopic mass: 2134.0 Da

Molecular weight: 2135.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 2153.5 Da N = 1; 2171.5 Da N = 2

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 153 - 242; Score: 65.6

TFBS definitions

Regulator	Description

LATD01000203.1 - Region 1 - lassopeptide

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Location: 3,662 - 17,219 nt. (total: 13,558 nt) Show pHMM detection rules used

Region on contig edge.

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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resistance

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Pfam domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acetyltransferase

ctg117_17: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: hydrolase

ctg117_15: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002006.2	0.62	ribosomal	albusnodin	Streptomyces albus
BGC0001634.3	0.40	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001775.3	0.36	terpene	sespendole	Cordana terrestris
BGC0000846.5	0.36	other (other)	tabtoxin	Pseudomonas syringae
BGC0000578.3	0.32	ribosomal	SRO15-2005	Streptomyces filamentosus NRRL 15998
BGC0002216.3	0.32	terpene	HEx-tc1 terpene	Trichoderma virens Gv29-8
BGC0002670.2	0.29	other (other)	fosfonochlorin	Fusarium oxysporum f. sp. lycopersici 4287
BGC0000894.4	0.28	other (other)	citrinin	Monascus aurantiacus
BGC0001435.4	0.27	NRPS, PKS	ikarugamycin	Streptomyces sp. ZJ306
BGC0002213.3	0.27	PKS	HEx-pks16 polyketide	Punctularia strigosozonata HHB-11173 SS5

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002006.2	0.62	ribosomal	albusnodin	Streptomyces albus
BGC0001634.3	0.40	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001775.3	0.36	terpene	sespendole	Cordana terrestris
BGC0000846.5	0.36	other (other)	tabtoxin	Pseudomonas syringae
BGC0000578.3	0.32	ribosomal	SRO15-2005	Streptomyces filamentosus NRRL 15998
BGC0002216.3	0.32	terpene	HEx-tc1 terpene	Trichoderma virens Gv29-8
BGC0002670.2	0.29	other (other)	fosfonochlorin	Fusarium oxysporum f. sp. lycopersici 4287
BGC0000894.4	0.28	other (other)	citrinin	Monascus aurantiacus
BGC0001435.4	0.27	NRPS, PKS	ikarugamycin	Streptomyces sp. ZJ306
BGC0002213.3	0.27	PKS	HEx-pks16 polyketide	Punctularia strigosozonata HHB-11173 SS5

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.29 out of 23.79

Confidence: medium

Additional weak hits (3):

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 22.24 out of 32.38

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.19 out of 26.85

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.35 out of 24.78

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Lasso peptides

TFBS Finder

Core peptide predictions

No core peptides found.

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism

LATD01000226.1 - Region 1 - terpene

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Location: 1 - 24,073 nt. (total: 24,073 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene overview

Tailoring

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ClusterBlast

KnownClusterBlast

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Terpene

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

ctg142_17: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

ctg142_3: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

ctg142_4: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

ctg142_7: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Transferases: aminotransferase methyltransferase

ctg142_21: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

ctg142_6: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

ctg142_8: methyltransferase

smcogs: SMCOG1089: methyltransferase

Lyases: cyclase

ctg142_16: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Ligases: synthase synthetase

ctg142_14: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

ctg142_19: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

ctg142_9: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000659.3	0.59	terpene	2-methylisoborneol	Saccharopolyspora erythraea NRRL 2338
BGC0000658.3	0.59	terpene	2-methylisoborneol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001911.3	0.58	terpene	raimonol	Streptomyces anulatus
BGC0000660.5	0.58	terpene	albaflavenone	Streptomyces coelicolor A3(2)
BGC0001910.4	0.57	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0002391.2	0.57	terpene	zealexin B3, zealexin C2	Zea mays
BGC0000677.5	0.56	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000657.5	0.55	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0002043.3	0.54	ribosomal	cittilin A, cittilin B	Myxococcus xanthus DK 1622
BGC0001361.3	0.54	terpene	sodorifen	Serratia plymuthica 4Rx13

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000659.3	0.59	terpene	2-methylisoborneol	Saccharopolyspora erythraea NRRL 2338
BGC0000658.3	0.59	terpene	2-methylisoborneol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001911.3	0.58	terpene	raimonol	Streptomyces anulatus
BGC0000660.5	0.58	terpene	albaflavenone	Streptomyces coelicolor A3(2)
BGC0001910.4	0.57	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0002391.2	0.57	terpene	zealexin B3, zealexin C2	Zea mays
BGC0000677.5	0.56	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000657.5	0.55	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0002043.3	0.54	ribosomal	cittilin A, cittilin B	Myxococcus xanthus DK 1622
BGC0001361.3	0.54	terpene	sodorifen	Serratia plymuthica 4Rx13

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
diterpene			C20	C6-C11 + C10-C15	PP

Genes with terpene domains:

ctg142_9: PT_FPPS_like

Domain 1 (70 - 335): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

ctg142_14: PT_FPPS_like

Domain 1 (2 - 276): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

ctg142_15: T2TS

Domain 1 (7 - 547): Type 2 terpene synthase

Subtype: Diterpene synthase

Reactions:: GGPP → diterpene_C6-C11/C10-C15_PP

ctg142_16: T1TS

Domain 1 (14 - 316): Type 1 terpene synthase

Subtype: unknown

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (2):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 18.52 out of 26.12

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 19.80 out of 33.14

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description

LATD01000229.1 - Region 1 - ectoine

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Location: 1 - 8,114 nt. (total: 8,114 nt) Show pHMM detection rules used

Region on contig edge.

ectoine: ectoine_synt

Legend:

core biosynthetic genes

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transport-related genes

regulatory genes

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resistance

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Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

ctg145_3: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Ligases: ligase

ctg145_8: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.60	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.60	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.59	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.59	NRPS	enniatin	Fusarium equiseti
BGC0001166.5	0.59	NRPS	HC-toxin	Alternaria jesenskae
BGC0001641.4	0.59	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.59	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.58	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.58	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001778.5	0.51	other (other)	showdomycin	Streptomyces showdoensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.60	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.60	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.59	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.59	NRPS	enniatin	Fusarium equiseti
BGC0001166.5	0.59	NRPS	HC-toxin	Alternaria jesenskae
BGC0001641.4	0.59	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.59	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.58	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.58	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001778.5	0.51	other (other)	showdomycin	Streptomyces showdoensis

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

LATD01000229.1 - Region 2 - butyrolactone

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Location: 23,004 - 29,011 nt. (total: 6,008 nt) Show pHMM detection rules used

Region on contig edge.

butyrolactone: AfsA

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Select a gene to view the details available for it

Gene overview

Tailoring

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ClusterBlast

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TFBS Finder

Pfam domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

ctg145_27: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000849.4	0.79	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000848.5	0.78	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000850.5	0.70	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002276.2	0.56	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002578.2	0.41	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0001928.2	0.39	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000231.5	0.38	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002161.2	0.37	PKS	scytalone, T3HN	Pestalotiopsis fici W106-1
BGC0001083.5	0.36	PKS, terpene	merochlorin A, merochlorin B, deschloro-merochlorin A, deschloro-merochlorin B, isochloro-merochlorin B, dichloro-merochlorin B, merochlorin D, merochlorin C	Streptomyces sp. CNH189
BGC0000197.5	0.36	PKS, saccharide	aranciamycin	Streptomyces echinatus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000849.4	0.79	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000848.5	0.78	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000850.5	0.70	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002276.2	0.56	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002578.2	0.41	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0001928.2	0.39	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000231.5	0.38	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002161.2	0.37	PKS	scytalone, T3HN	Pestalotiopsis fici W106-1
BGC0001083.5	0.36	PKS, terpene	merochlorin A, merochlorin B, deschloro-merochlorin A, deschloro-merochlorin B, isochloro-merochlorin B, dichloro-merochlorin B, merochlorin D, merochlorin C	Streptomyces sp. CNH189
BGC0000197.5	0.36	PKS, saccharide	aranciamycin	Streptomyces echinatus

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52

Confidence: strong

Additional weak hits (5):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.27 out of 18.57

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.37 out of 26.06

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.70 out of 21.55

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.46 out of 21.55

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.88 out of 28.19

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
ZuR variant 1	Zinc-responsive repressor

LATD01000231.1 - Region 1 - NRPS

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Location: 1 - 30,647 nt. (total: 30,647 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

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resistance

TTA codons

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NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

ctg148_6: nucleotide sugar dehydrogenase

smcogs: SMCOG1152: nucleotide sugar dehydrogenase

Transferases: acyltransferase

ctg148_10: polyketide synthase associated protein papA3

smcogs: SMCOG1209: polyketide synthase associated protein papA3

Ligases: ligase

ctg148_11: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.72	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.70	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001135.5	0.70	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.72	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.70	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001135.5	0.70	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (6):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.44 out of 18.57

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.90 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.49 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.06 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.81 out of 26.06

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.77 out of 21.55

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 30647:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile - Pro) + (Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg148_10: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (540..945): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAHFLGGLYK
Nearest Stachelhaus code(s):: Ile DAMFLGCTYK (53% 8Å match)
Stachelhaus code match:: 70% (weak)

ctg148_11: Ile - Pro

Search NORINE for peptide: strict or relaxed

AMP-binding (22..480): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFLGVTFK
Nearest Stachelhaus code(s):: Ile DAFFLGVTFK (68% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1150..1565): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFIAHVVK
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (76% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description

LATD01000024.1 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 78,961 nt. (total: 78,961 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

ctg157_2: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

ctg157_4: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: acylase aminotransferase glycosyltransferase

ctg157_5: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

ctg157_6: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

ctg157_8: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: esterase

ctg157_10: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: synthase

ctg157_1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ctg157_7: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ctg157_9: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	0.73	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000041.3	0.72	PKS	oronofacic acid	Pseudomonas syringae
BGC0000016.4	0.72	other (other)	amphotericin B	Streptomyces nodosus
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002154.2	0.64	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.64	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	0.73	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000041.3	0.72	PKS	oronofacic acid	Pseudomonas syringae
BGC0000016.4	0.72	other (other)	amphotericin B	Streptomyces nodosus
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002154.2	0.64	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.64	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.57 out of 23.79

Confidence: medium

Additional weak hits (9):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.45 out of 30.25

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.95 out of 21.55

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.75 out of 27.78

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.60 out of 30.98

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.60 out of 29.65

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.04 out of 29.25

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.55 out of 18.57

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 19.66 out of 33.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.62 out of 28.19

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 78961:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (Me-ohmal - Me-ohmal) + (ccmal - redmal - ccmal - ccmal - ccmal - ccmal) + (ccmal)
Non-colinear ordering:: ctg157_7 + ctg157_8 + ctg157_9 + ctg157_1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg157_1: mal

PKS_AT (573..864): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 231.8
inactive: 104.2
Methylmalonyl-CoA: 54.8
Methoxymalonyl-CoA: 54.8
Propionyl-CoA: 36.4
Benzoyl-CoA: 20.1
2-Methylbutyryl-CoA: 18.9
Isobutyryl-CoA: 18.7
Ethylmalonyl-CoA: 16.2
Acetyl-CoA: 15.2
CHC-CoA: 13.4
trans-1,2-CPDA: 7.7
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

ctg157_7: mal

PKS_AT (584..879): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 231.4
inactive: 119.5
Methoxymalonyl-CoA: 62.5
Methylmalonyl-CoA: 62.4
Isobutyryl-CoA: 33.2
Propionyl-CoA: 32.0
2-Methylbutyryl-CoA: 19.8
Acetyl-CoA: 19.7
Benzoyl-CoA: 19.5
Ethylmalonyl-CoA: 18.0
CHC-CoA: 15.8
trans-1,2-CPDA: 7.1
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

ctg157_8: mmal - mmal

PKS_AT (569..867): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 218.7
Ethylmalonyl-CoA: 200.5
Methoxymalonyl-CoA: 174.6
trans-1,2-CPDA: 132.6
2-Methylbutyryl-CoA: 130.8
CHC-CoA: 107.2
Propionyl-CoA: 105.3
Isobutyryl-CoA: 99.0
Malonyl-CoA: 82.3
Benzoyl-CoA: 78.8
3-Methylbutyryl-CoA: 41.8
Acetyl-CoA: 38.3
fatty_acid: 33.8
inactive: 20.8

PKS_AT (2112..2411): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 215.8
Ethylmalonyl-CoA: 202.9
Methoxymalonyl-CoA: 181.4
2-Methylbutyryl-CoA: 146.3
trans-1,2-CPDA: 133.3
Propionyl-CoA: 110.3
Malonyl-CoA: 109.4
CHC-CoA: 103.8
Isobutyryl-CoA: 79.6
Benzoyl-CoA: 64.7
Acetyl-CoA: 51.8
3-Methylbutyryl-CoA: 44.5
fatty_acid: 36.6
inactive: 28.8

ctg157_9: mal - mal - mal - mal - mal - mal

PKS_AT (561..853): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 227.8
inactive: 93.9
Methoxymalonyl-CoA: 57.0
Methylmalonyl-CoA: 49.3
Isobutyryl-CoA: 25.1
Propionyl-CoA: 22.8
Acetyl-CoA: 21.8
Ethylmalonyl-CoA: 21.7
Benzoyl-CoA: 19.3
CHC-CoA: 9.7
2-Methylbutyryl-CoA: 6.5
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2333..2623): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 237.8
inactive: 110.7
Methoxymalonyl-CoA: 66.4
Methylmalonyl-CoA: 61.4
Propionyl-CoA: 40.7
Isobutyryl-CoA: 27.5
Benzoyl-CoA: 21.9
Acetyl-CoA: 21.9
2-Methylbutyryl-CoA: 20.5
Ethylmalonyl-CoA: 20.1
CHC-CoA: 16.2
fatty_acid: 10.5
trans-1,2-CPDA: 8.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (4407..4697): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 237.4
inactive: 112.6
Methoxymalonyl-CoA: 66.1
Methylmalonyl-CoA: 61.8
Isobutyryl-CoA: 28.0
Propionyl-CoA: 26.3
Benzoyl-CoA: 20.9
Ethylmalonyl-CoA: 19.7
Acetyl-CoA: 17.3
trans-1,2-CPDA: 13.1
2-Methylbutyryl-CoA: 9.5
CHC-CoA: 8.4
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (6169..6459): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 237.5
inactive: 107.1
Methoxymalonyl-CoA: 62.9
Methylmalonyl-CoA: 57.1
Propionyl-CoA: 37.3
Isobutyryl-CoA: 23.6
Benzoyl-CoA: 20.6
Acetyl-CoA: 20.6
Ethylmalonyl-CoA: 19.6
2-Methylbutyryl-CoA: 18.3
CHC-CoA: 14.7
fatty_acid: 10.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (7913..8203): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 233.7
inactive: 110.5
Methoxymalonyl-CoA: 59.3
Methylmalonyl-CoA: 56.9
Propionyl-CoA: 31.3
Isobutyryl-CoA: 26.6
Ethylmalonyl-CoA: 21.7
Benzoyl-CoA: 18.1
Acetyl-CoA: 17.0
2-Methylbutyryl-CoA: 14.9
CHC-CoA: 13.2
fatty_acid: 10.6
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (9677..9967): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 244.2
inactive: 112.1
Methoxymalonyl-CoA: 69.8
Methylmalonyl-CoA: 63.3
Propionyl-CoA: 40.8
Isobutyryl-CoA: 29.8
2-Methylbutyryl-CoA: 26.9
Ethylmalonyl-CoA: 25.4
Benzoyl-CoA: 21.3
Acetyl-CoA: 21.1
CHC-CoA: 15.3
fatty_acid: 10.8
trans-1,2-CPDA: 10.5
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism

LATD01000255.1 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 1 - 27,525 nt. (total: 27,525 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

ctg174_18: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: deacetylase

ctg174_15: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Ligases: ligase

ctg174_17: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.69	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000357.5	0.67	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0002135.2	0.67	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.66	NRPS	icosalide A, icosalide B	Burkholderia gladioli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.69	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000357.5	0.67	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0002135.2	0.67	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.66	NRPS	icosalide A, icosalide B	Burkholderia gladioli

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

Additional weak hits (9):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.92 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.89 out of 29.38

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 20.96 out of 36.54

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.23 out of 30.98

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.17 out of 18.57

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.11 out of 18.57

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.06 out of 29.65

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.83 out of 36.53

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.17 out of 27.18

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 27525:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Aad - Cys - D-Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg174_17: Aad - Cys - Val

Search NORINE for peptide: strict or relaxed

AMP-binding (266..684): Aad

nrpys: Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: aad (Aad)
Single AA prediction:: aad (Aad)

Stachelhaus prediction details:

Stachelhaus sequence:: EPRNLVEFVK
Nearest Stachelhaus code(s):: Aad EPRNLVEFVK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1383..1791): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DHESDIGITK
Nearest Stachelhaus code(s):: Cys DHESDIGITK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2494..2899): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DFESLAAVYK
Nearest Stachelhaus code(s):: Val DFESLAAVYK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production

LATD01000263.1 - Region 1 - T2PKS

Download region GenBank file

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Location: 1 - 22,499 nt. (total: 22,499 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

ctg183_9: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: acetyltransferase acylase glycosyltransferase

ctg183_10: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

ctg183_27: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

ctg183_4: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Ligases: synthase

ctg183_6: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

ctg183_7: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ctg183_8: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000231.5	0.67	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.62	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272.3	0.62	PKS	spore pigment	Streptomyces collinus
BGC0001723.5	0.58	PKS	oviedomycin	Streptomyces antibioticus
BGC0001164.3	0.58	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000275.4	0.57	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001197.5	0.55	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000271.5	0.54	PKS	spore pigment	Streptomyces avermitilis
BGC0000217.5	0.53	PKS	daunorubicin	Streptomyces sp.
BGC0001513.3	0.53	PKS	anthrabenzoxocinone	Actinobacteria bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000231.5	0.67	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.62	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272.3	0.62	PKS	spore pigment	Streptomyces collinus
BGC0001723.5	0.58	PKS	oviedomycin	Streptomyces antibioticus
BGC0001164.3	0.58	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000275.4	0.57	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001197.5	0.55	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000271.5	0.54	PKS	spore pigment	Streptomyces avermitilis
BGC0000217.5	0.53	PKS	daunorubicin	Streptomyces sp.
BGC0001513.3	0.53	PKS	anthrabenzoxocinone	Actinobacteria bacterium

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

Additional weak hits (7):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 23.19 out of 30.11

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.56 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.85 out of 28.14

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.85 out of 36.54

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.60 out of 21.84

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.81 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.88 out of 33.14

Confidence: weak

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

TFBS Finder

NRPS/PKS substrate predictions

ctg183_4: mal

PKS_AT (274..554): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 69.7
Methoxymalonyl-CoA: 52.5
Methylmalonyl-CoA: 42.0
Propionyl-CoA: 28.6
inactive: 22.4
Acetyl-CoA: 11.6
2-Methylbutyryl-CoA: 8.5
Ethylmalonyl-CoA: 6.9
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 22499
Starter unit(s):: 2-methylbutyryl-CoA (Score: 299.0; E-value: 2.33e-96)
Malonyl elongations:: 8|9 (Score: 663.2; E-value: 2.6e-202)
Product class(es):: angucycline
anthracycline
aureolic acid
tetracenomycin
tetracycline
Product molecular weight(s):: 2-methylbutyryl-CoA_8: 601 Da
2-methylbutyryl-CoA_9: 643 Da

ctg183_10: GT (Score: 128.5; E-value: 9.9e-40)
ctg183_4: AT (Score: 396.7; E-value: 1.9e-121); AT ADB23379.1_TLN-05220/TLN-05223_2-methylbutyryl-CoA (Score: 299.0; E-value: 2.33e-96)
ctg183_5: ACP (Score: 114.2; E-value: 5e-36)
ctg183_6: CLF 8|9 (Score: 663.2; E-value: 2.6e-202)
ctg183_7: KS (Score: 465.0; E-value: 4.8e-142)

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein

LATD01000027.1 - Region 1 - terpene

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Location: 19,849 - 40,181 nt. (total: 20,333 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

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Gene overview

Tailoring

MIBiG comparison

ClusterBlast

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SubClusterBlast

Terpene

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

ctg190_39: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000244.4	0.42	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0000706.3	0.39	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000207.5	0.35	PKS	chartreusin	Streptomyces chartreusis
BGC0000518.3	0.35	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000003.3	0.34	PKS	AF-toxin	Alternaria alternata
BGC0002412.2	0.32	NRPS	holomycin	Photobacterium galatheae
BGC0000783.3	0.31	saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0000274.5	0.31	PKS	tetarimycin A, tetarimycin B	uncultured bacterium
BGC0000959.5	0.30	NRPS, PKS	aspyridone A, aspyridone B	Aspergillus nidulans FGSC A4
BGC0001625.5	0.30	PKS	Isofuranonaphthoquinone A, Isofuranonaphthoquinone B, Isofuranonaphthoquinone C, Isofuranonaphthoquinone D, Isofuranonaphthoquinone E, Isofuranonaphthoquinone F	Streptomyces sp. CB01883

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000244.4	0.42	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0000706.3	0.39	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000207.5	0.35	PKS	chartreusin	Streptomyces chartreusis
BGC0000518.3	0.35	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000003.3	0.34	PKS	AF-toxin	Alternaria alternata
BGC0002412.2	0.32	NRPS	holomycin	Photobacterium galatheae
BGC0000783.3	0.31	saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0000274.5	0.31	PKS	tetarimycin A, tetarimycin B	uncultured bacterium
BGC0000959.5	0.30	NRPS, PKS	aspyridone A, aspyridone B	Aspergillus nidulans FGSC A4
BGC0001625.5	0.30	PKS	Isofuranonaphthoquinone A, Isofuranonaphthoquinone B, Isofuranonaphthoquinone C, Isofuranonaphthoquinone D, Isofuranonaphthoquinone E, Isofuranonaphthoquinone F	Streptomyces sp. CB01883

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

No product predictions

Genes with terpene domains:

No domains found

Transcription Factor Binding Sites

Binding sites found:

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.00 out of 26.85

Confidence: medium

Additional weak hits (5):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.61 out of 21.55

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.65 out of 27.55

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.32 out of 28.14

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.37 out of 39.62

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.88 out of 28.19

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
RutR	Regulator of the pyrimidine and purine metabolism

LATD01000028.1 - Region 1 - NI-siderophore

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Location: 21,695 - 54,492 nt. (total: 32,798 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

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Gene overview

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Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

ctg201_21: Antibiotic biosynthesis monooxygenase

smcogs: SMCOG1258: Antibiotic biosynthesis monooxygenase

Transferases: aminotransferase

ctg201_33: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Isomerases: mutase

ctg201_20: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002692.2	0.55	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000942.4	0.54	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001713.5	0.53	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0002683.2	0.51	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0002633.2	0.51	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002469.2	0.51	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0002470.2	0.51	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002
BGC0001572.3	0.50	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0000939.5	0.50	other (other)	aerobactin	Grimontia hollisae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002692.2	0.55	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000942.4	0.54	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001713.5	0.53	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0002683.2	0.51	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0002633.2	0.51	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002469.2	0.51	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0002470.2	0.51	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002
BGC0001572.3	0.50	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0000939.5	0.50	other (other)	aerobactin	Grimontia hollisae

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.18 out of 20.47

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 24.62 out of 27.18

Confidence: strong

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 25.08 out of 27.18

Confidence: strong

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52

Confidence: strong

Additional weak hits (9):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.03 out of 31.73

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.18 out of 26.33

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.14 out of 25.75

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.84 out of 23.43

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.15 out of 32.74

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.85 out of 18.57

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.56 out of 29.38

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.88 out of 29.65

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CRP	Cyclic AMP receptor protein
NrdR	Represses ribonucleotide reductase encoding genes
RpoN	Regulator of nitrogen assimilation and virulence
VqsM	Regulator of quorum-sensing signalling systems

LATD01000283.1 - Region 1 - T3PKS,melanin

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Location: 1 - 23,191 nt. (total: 23,191 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
melanin: melC

Legend:

core biosynthetic genes

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resistance

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TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthase

ctg205_6: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000911.3	1.04	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000910.3	1.02	other (other)	melanin	Streptomyces coelicolor A3(2)
BGC0000909.3	0.62	other (other)	melanin	Streptomyces avermitilis
BGC0000908.3	0.54	other (other)	melanin	Streptomyces avermitilis
BGC0000912.3	0.52	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000662.5	0.29	terpene	grixazone A	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000885.3	0.28	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000551.5	0.27	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0002306.2	0.27	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000558.5	0.26	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000911.3	0.80	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000910.3	0.79	other (other)	melanin	Streptomyces coelicolor A3(2)
BGC0000909.3	0.64	other (other)	melanin	Streptomyces avermitilis
BGC0000908.3	0.60	other (other)	melanin	Streptomyces avermitilis
BGC0000912.3	0.59	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000902.4	0.55	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0002127.3	0.54	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0000285.5	0.54	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0001310.5	0.53	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0000849.4	0.48	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.79 out of 25.31

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.37 out of 27.04

Confidence: medium

Additional weak hits (3):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.18 out of 26.33

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.79 out of 20.97

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.90 out of 28.19

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CatR	H2O2-responsive repressor
DasR	N-acetylglucosamine dependent repressor
VqsM	Regulator of quorum-sensing signalling systems

LATD01000302.1 - Region 1 - RiPP-like

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Location: 1 - 7,766 nt. (total: 7,766 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002788.2	0.29	PKS	14-hydroxyisochainin	Streptomyces peucetius subsp. caesius ATCC 27952
BGC0002387.2	0.28	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0001377.5	0.25	PKS	uncialamycin	Streptomyces uncialis
BGC0001060.5	0.22	PKS	dynemicin A	Micromonospora chersina
BGC0001984.3	0.21	NRPS	sarpeptin A, sarpeptin B	Streptomyces sp.
BGC0000241.5	0.19	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora tropica CNB-440
BGC0001693.3	0.19	PKS	nenestatin	Micromonospora echinospora

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002788.2	0.29	PKS	14-hydroxyisochainin	Streptomyces peucetius subsp. caesius ATCC 27952
BGC0002387.2	0.28	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0001377.5	0.25	PKS	uncialamycin	Streptomyces uncialis
BGC0001060.5	0.22	PKS	dynemicin A	Micromonospora chersina
BGC0001984.3	0.21	NRPS	sarpeptin A, sarpeptin B	Streptomyces sp.
BGC0000241.5	0.19	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora tropica CNB-440
BGC0001693.3	0.19	PKS	nenestatin	Micromonospora echinospora

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 22.96 out of 27.18

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

Additional weak hits (1):

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.74 out of 32.93

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
NrdR	Represses ribonucleotide reductase encoding genes
VqsM	Regulator of quorum-sensing signalling systems

LATD01000309.1 - Region 1 - terpene

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Location: 1 - 5,032 nt. (total: 5,032 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Pfam domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: Oxidation

ctg234_7: Oxidation

MITE: MITE0000108Oxidation (identity: 67.60%)

Lyases: cyclase

ctg234_6: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001911.3	0.52	terpene	raimonol	Streptomyces anulatus
BGC0001910.4	0.49	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000602.5	0.36	ribosomal	subtilosin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001929.2	0.35	ribosomal	WGK	Streptococcus ferus
BGC0002583.2	0.35	ribosomal	tryglysin B	Streptococcus mutans UA159
BGC0002372.3	0.25	PKS, other (other), terpene	marinoterpin B, marinoterpin A, marinoterpin C	Streptomyces sp.
BGC0001025.5	0.23	NRPS, PKS	myxovirescin A1	Myxococcus xanthus DK 1622

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001911.3	0.52	terpene	raimonol	Streptomyces anulatus
BGC0001910.4	0.49	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000602.5	0.36	ribosomal	subtilosin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001929.2	0.35	ribosomal	WGK	Streptococcus ferus
BGC0002583.2	0.35	ribosomal	tryglysin B	Streptococcus mutans UA159
BGC0002372.3	0.25	PKS, other (other), terpene	marinoterpin B, marinoterpin A, marinoterpin C	Streptomyces sp.
BGC0001025.5	0.23	NRPS, PKS	myxovirescin A1	Myxococcus xanthus DK 1622

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
diterpene			C20	C6-C11 + C10-C15	none

Genes with terpene domains:

ctg234_6: T1TS

Domain 1 (2 - 162): Type 1 terpene synthase

Subtype: Labdatriene synthase type

Reactions:: diterpene_C6-C11/C10-C15_PP → diterpene_C6-C11/C10-C15

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (1):

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.56 out of 29.51

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description

LATD01000319.1 - Region 1 - RRE-containing,azole-containing-RiPP

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Location: 2,280 - 37,173 nt. (total: 34,894 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

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Azole RiPPs

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

ctg245_29: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Hydrolases: deacetylase hydrolase

ctg245_23: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

ctg245_24: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

Lyases: dehydratase

ctg245_16: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

ctg245_17: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001145.5	0.41	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001146.5	0.37	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000603.5	0.36	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0001174.4	0.33	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000566.5	0.33	ribosomal	streptolysin S	Streptococcus pyogenes M1 GAS
BGC0000607.5	0.32	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001640.3	0.31	ribosomal	kocurin	Kocuria rosea
BGC0002144.3	0.31	ribosomal	phazolicin	Rhizobium sp. Pop5
BGC0002115.3	0.31	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0000568.5	0.30	ribosomal	microcin B17	Escherichia coli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002084.4	0.57	ribosomal	biarylitide YYH	Planomonospora sp. ID82291
BGC0002099.3	0.57	ribosomal	biarylitide YFH	Planomonospora sp. ID107089
BGC0001145.5	0.54	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001310.5	0.51	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0000603.5	0.51	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0001146.5	0.51	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001948.3	0.49	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0002127.3	0.48	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0002120.3	0.48	ribosomal	nocathioamide A	Nocardia terpenica IFM 0706
BGC0000566.5	0.48	ribosomal	streptolysin S	Streptococcus pyogenes M1 GAS

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.35 out of 20.47

Confidence: strong

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.52 out of 29.72

Confidence: medium

Additional weak hits (7):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.82 out of 27.78

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.73 out of 21.55

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.33 out of 30.97

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.45 out of 21.55

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.63 out of 30.98

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

RREFinder

TFBS Finder

Azole RiPPs

RRE predictions

: RRE type: Thiopeptide_F_RRE; Location: 9 - 88; Score: 61.7; RRE type: Heterocycloanthracin_C_RRE; Location: 9 - 94; Score: 38.5
: RRE type: Thiopeptide_F_RRE; Location: 9 - 88; Score: 61.7; RRE type: Heterocycloanthracin_C_RRE; Location: 9 - 94; Score: 38.5

TFBS definitions

Regulator	Description
NtrC	Nitrogen regulatory protein C
VqsM	Regulator of quorum-sensing signalling systems

Core peptide predictions

No core peptides found.

LATD01000339.1 - Region 1 - NRPS

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Location: 1 - 13,986 nt. (total: 13,986 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

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NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

ctg267_1: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000342.4	0.73	NRPS	enniatin	Fusarium equiseti
BGC0002135.2	0.67	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000423.5	0.66	NRPS	scabichelin	Streptomyces scabiei 87.22
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0000307.4	0.66	NRPS	AbT1	Aureobasidium pullulans
BGC0001135.5	0.66	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001825.4	0.65	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.65	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.65	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.65	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000342.4	0.73	NRPS	enniatin	Fusarium equiseti
BGC0002135.2	0.67	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000423.5	0.66	NRPS	scabichelin	Streptomyces scabiei 87.22
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0000307.4	0.66	NRPS	AbT1	Aureobasidium pullulans
BGC0001135.5	0.66	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001825.4	0.65	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.65	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.65	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.65	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 13986:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NMe-OH-Orn - Orn - D-OH-Orn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg267_1: OH-Orn - Orn - OH-Orn

Search NORINE for peptide: strict or relaxed

AMP-binding (601..1002): OH-Orn

nrpys: OH-Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: DMENLGLINK
Nearest Stachelhaus code(s):: OH-Orn DMENLGLINK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2048..2467): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: N/A
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: DGEDAGLVDK
Nearest Stachelhaus code(s):: Orn DGEDAGLVDK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3124..3534): OH-Orn

nrpys: OH-Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAQEGGLVDK
Nearest Stachelhaus code(s):: OH-Orn DAQEGGLVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

LATD01000393.1 - Region 1 - terpene

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Location: 1 - 9,976 nt. (total: 9,976 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

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resistance

TTA codons

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Gene details

Select a gene to view the details available for it

Gene overview

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Terpene

TFBS Finder

Pfam domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

ctg327_5: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Lyases: cyclase

ctg327_4: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001910.4	0.36	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001911.3	0.36	terpene	raimonol	Streptomyces anulatus
BGC0001483.4	0.33	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0001197.5	0.31	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001223.5	0.28	other (other)	hydroxysporine	uncultured bacterium
BGC0001605.3	0.27	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001012.3	0.26	NRPS, PKS	meridamycin	Streptomyces violaceusniger
BGC0002805.2	0.26	other (other)	Azodyrecin A, Azodyrecin B, Azodyrecin C	Streptomyces mirabilis strain P8-A
BGC0001840.2	0.25	NRPS, PKS	detoxin S1	Streptomyces sp. NRRL S-325

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001910.4	0.36	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001911.3	0.36	terpene	raimonol	Streptomyces anulatus
BGC0001483.4	0.33	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0001197.5	0.31	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001223.5	0.28	other (other)	hydroxysporine	uncultured bacterium
BGC0001605.3	0.27	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001012.3	0.26	NRPS, PKS	meridamycin	Streptomyces violaceusniger
BGC0002805.2	0.26	other (other)	Azodyrecin A, Azodyrecin B, Azodyrecin C	Streptomyces mirabilis strain P8-A
BGC0001840.2	0.25	NRPS, PKS	detoxin S1	Streptomyces sp. NRRL S-325

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

No product predictions

Genes with terpene domains:

ctg327_4: T1TS

Domain 1 (13 - 318): Type 1 terpene synthase

Subtype: unknown

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (4):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.45 out of 18.57

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.18 out of 26.33

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.48 out of 29.25

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.67 out of 23.43

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description

LATD01000402.1 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 8,564 nt. (total: 8,564 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

NRPS/PKS modules

Pfam domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000056.3	0.62	PKS	esperamicin	Actinomadura verrucosospora
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.62	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.62	PKS	FR901512	fungal sp. No.14919
BGC0001160.5	0.61	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000056.3	0.62	PKS	esperamicin	Actinomadura verrucosospora
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.62	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.62	PKS	FR901512	fungal sp. No.14919
BGC0001160.5	0.61	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Similar known clusters

No significant matches found.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 8564:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg338_1: mal - mal

PKS_AT (615..905): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 228.1
inactive: 111.1
Methoxymalonyl-CoA: 66.2
Methylmalonyl-CoA: 61.8
Isobutyryl-CoA: 38.7
Propionyl-CoA: 36.0
2-Methylbutyryl-CoA: 24.0
Ethylmalonyl-CoA: 23.6
Acetyl-CoA: 22.5
Benzoyl-CoA: 21.9
CHC-CoA: 13.3
fatty_acid: 11.0
trans-1,2-CPDA: 9.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (2163..2457): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 244.2
inactive: 123.3
Methoxymalonyl-CoA: 78.1
Methylmalonyl-CoA: 77.6
Propionyl-CoA: 41.2
Isobutyryl-CoA: 39.0
2-Methylbutyryl-CoA: 29.2
Benzoyl-CoA: 29.1
Acetyl-CoA: 26.4
Ethylmalonyl-CoA: 25.9
CHC-CoA: 23.4
fatty_acid: 19.5
trans-1,2-CPDA: 12.6
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

LATD01000439.1 - Region 1 - ectoine

Download region GenBank file

Download region SVG

Location: 1 - 6,981 nt. (total: 6,981 nt) Show pHMM detection rules used

Region on contig edge.

ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

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Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

ctg378_4: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Transferases: aminotransferase

ctg378_1: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: hydrolase

ctg378_6: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.79	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.78	other (ectoine)	ectoine	Streptomyces sp.
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000859.3	0.65	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000855.3	0.65	other (other)	ectoine	Methylomicrobium kenyense
BGC0000856.3	0.65	other (other)	ectoine	Methylophaga thalassica
BGC0000860.3	0.63	other (other)	ectoine	Methylarcula marina
BGC0000857.3	0.63	other (other)	ectoine	Methylophaga alcalica
BGC0000854.3	0.61	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.79	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.78	other (ectoine)	ectoine	Streptomyces sp.
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000859.3	0.65	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000855.3	0.65	other (other)	ectoine	Methylomicrobium kenyense
BGC0000856.3	0.65	other (other)	ectoine	Methylophaga thalassica
BGC0000860.3	0.63	other (other)	ectoine	Methylarcula marina
BGC0000857.3	0.63	other (other)	ectoine	Methylophaga alcalica
BGC0000854.3	0.61	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

LATD01000044.1 - Region 1 - NRP-metallophore,NRPS

Download region GenBank file

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Location: 1 - 27,359 nt. (total: 27,359 nt) Show pHMM detection rules used

Region on contig edge.

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

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regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

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TFBS Finder

NRPS/PKS modules

Pfam domains

TIGRFAM domains

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

ctg379_11: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

ctg379_6: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

Transferases: formyltransferase glycosyltransferase

ctg379_15: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

ctg379_5: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

Lyases: hydratase

ctg379_16: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

ctg379_17: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

Ligases: ligase

ctg379_1: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.59	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000307.4	0.59	NRPS	AbT1	Aureobasidium pullulans
BGC0002135.2	0.59	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.59	NRPS	AM-toxin	Alternaria alternata
BGC0001166.5	0.58	NRPS	HC-toxin	Alternaria jesenskae
BGC0000342.4	0.58	NRPS	enniatin	Fusarium equiseti
BGC0000357.5	0.58	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001240.4	0.58	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002164.2	0.56	NRPS	peramine	Epichloe festucae
BGC0001833.4	0.56	NRPS	icosalide A, icosalide B	Burkholderia gladioli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.63	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.63	NRPS	AM-toxin	Alternaria alternata
BGC0001166.5	0.63	NRPS	HC-toxin	Alternaria jesenskae
BGC0000342.4	0.63	NRPS	enniatin	Fusarium equiseti
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001240.4	0.62	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002164.2	0.62	NRPS	peramine	Epichloe festucae
BGC0001833.4	0.61	NRPS	icosalide A, icosalide B	Burkholderia gladioli

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (2):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.57 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 26.03 out of 36.53

Confidence: weak

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 27359:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NMe-Fo-OH-Orn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg379_1: Fo-OH-Orn - Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (248..651): Fo-OH-Orn

nrpys: Fo-OH-Orn

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVWILGATNK
Nearest Stachelhaus code(s):: Fo-OH-Orn DVWILGATNK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1712..2117): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLVDK
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description

LATD01000497.1 - Region 1 - terpene

Download region GenBank file

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Location: 1 - 8,527 nt. (total: 8,527 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Pfam domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

ctg442_1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000660.5	0.52	terpene	albaflavenone	Streptomyces coelicolor A3(2)
BGC0001911.3	0.48	terpene	raimonol	Streptomyces anulatus
BGC0001910.4	0.46	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000675.5	0.41	terpene	(+)-T-muurolol	Streptomyces clavuligerus ATCC 27064
BGC0000677.5	0.38	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000286.3	0.35	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0000678.5	0.29	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002347.3	0.28	other (other)	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus caeruleus WH1-2216-6
BGC0002293.2	0.26	NRPS	ohmyungsamycin A, ohmyungsamycin B	Streptomyces sp.
BGC0000603.5	0.26	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000660.5	0.52	terpene	albaflavenone	Streptomyces coelicolor A3(2)
BGC0001911.3	0.48	terpene	raimonol	Streptomyces anulatus
BGC0001910.4	0.46	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000675.5	0.41	terpene	(+)-T-muurolol	Streptomyces clavuligerus ATCC 27064
BGC0000677.5	0.38	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000286.3	0.35	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0000678.5	0.29	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002347.3	0.28	other (other)	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus caeruleus WH1-2216-6
BGC0002293.2	0.26	NRPS	ohmyungsamycin A, ohmyungsamycin B	Streptomyces sp.
BGC0000603.5	0.26	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
diterpene			C20	C6-C11 + C10-C15	PP

Genes with terpene domains:

ctg442_2: T2TS

Domain 1 (1 - 216): Type 2 terpene synthase

Subtype: Diterpene synthase

Reactions:: GGPP → diterpene_C6-C11/C10-C15_PP

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (4):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.98 out of 30.22

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.04 out of 29.65

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.33 out of 23.43

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Terpene

TFBS Finder

Glossary

Acronym	Full name
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description

LATD01000500.1 - Region 1 - RiPP-like

Download region GenBank file

Download region SVG

Location: 1 - 8,039 nt. (total: 8,039 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

ClusterBlast

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SubClusterBlast

TFBS Finder

Pfam domains

TIGRFAM domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: hydratase

ctg447_7: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.40	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000486.4	0.40	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001887.3	0.40	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001743.3	0.39	ribosomal	plantaricyclin	Lactobacillus plantarum
BGC0000626.3	0.36	ribosomal	thuricin	Bacillus thuringiensis
BGC0000563.4	0.36	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000538.3	0.36	ribosomal	nisin Z	Lactococcus lactis
BGC0000551.5	0.36	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0001210.5	0.36	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.40	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000486.4	0.40	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001887.3	0.40	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001743.3	0.39	ribosomal	plantaricyclin	Lactobacillus plantarum
BGC0000626.3	0.36	ribosomal	thuricin	Bacillus thuringiensis
BGC0000563.4	0.36	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000538.3	0.36	ribosomal	nisin Z	Lactococcus lactis
BGC0000551.5	0.36	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0001210.5	0.36	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Similar known clusters

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.68 out of 19.52

Confidence: medium

Additional weak hits (1):

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.80 out of 32.93

Confidence: weak

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production

LATD01000054.1 - Region 1 - T3PKS

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Location: 9,945 - 50,928 nt. (total: 40,984 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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Pfam domains

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Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase reductase

ctg490_41: oxidoreductase

smcogs: SMCOG1161: oxidoreductase

ctg490_47: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

ctg490_48: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

Transferases: kinase methyltransferase

ctg490_40: Methylation

MITE: MITE0000155Methylation (identity: 78.50%)
smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

ctg490_49: glycerol kinase

smcogs: SMCOG1210: glycerol kinase

Ligases: synthase

ctg490_39: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Translocases: permease

ctg490_51: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.83	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.53	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001077.4	0.46	PKS	6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone	Actinoplanes missouriensis 431
BGC0002362.3	0.45	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0000908.3	0.43	other (other)	melanin	Streptomyces avermitilis
BGC0000551.5	0.43	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000519.4	0.41	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0001964.2	0.41	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0000626.3	0.40	ribosomal	thuricin	Bacillus thuringiensis
BGC0001647.3	0.39	PKS	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.83	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.53	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001077.4	0.46	PKS	6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone	Actinoplanes missouriensis 431
BGC0002362.3	0.45	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0000908.3	0.43	other (other)	melanin	Streptomyces avermitilis
BGC0000551.5	0.43	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000519.4	0.41	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0001964.2	0.41	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0000626.3	0.40	ribosomal	thuricin	Bacillus thuringiensis
BGC0001647.3	0.39	PKS	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 22.05 out of 22.40

Confidence: strong

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.05 out of 26.85

Confidence: medium

Additional weak hits (9):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.96 out of 20.97

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.04 out of 21.55

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.17 out of 21.55

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.92 out of 26.33

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.86 out of 21.55

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.01 out of 30.11

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.30 out of 32.74

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.52 out of 29.65

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.16 out of 30.98

Confidence: weak

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

TFBS Finder

TFBS definitions

Regulator	Description
HypR	L-hydroxyproline utilization repressor
RutR	Regulator of the pyrimidine and purine metabolism

LATD01000059.1 - Region 1 - T1PKS,phenazine

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Location: 1 - 48,671 nt. (total: 48,671 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
phenazine: phzB

Legend:

core biosynthetic genes

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NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

ctg545_10: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

ctg545_11: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

ctg545_22: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

Transferases: aminotransferase methyltransferase

ctg545_12: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

ctg545_4: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: esterase

ctg545_17: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: synthase

ctg545_5: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ctg545_6: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ctg545_7: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001244.3	0.72	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.72	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.72	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001276.3	0.60	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002191.2	0.59	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001164.3	0.58	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.58	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001284.4	0.57	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002175.3	0.56	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002192.3	0.56	PKS	FR901512	fungal sp. No.14919

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.74	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.74	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.74	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001257.3	0.64	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.37 out of 20.47

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

Additional weak hits (14):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.43 out of 30.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.55 out of 27.78

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.07 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.54 out of 28.14

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.75 out of 20.97

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 17.35 out of 36.54

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.39 out of 30.22

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.95 out of 30.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 14.59 out of 27.78

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.05 out of 27.04

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.86 out of 19.52

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.87 out of 30.97

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.88 out of 30.25

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.58 out of 29.65

Confidence: weak

Module view

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 48671:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ccmal - ccmal) + (ohmal) + (ccmal)
Non-colinear ordering:: ctg545_7 + ctg545_6 + ctg545_5

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg545_5: mal

PKS_AT (563..857): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 213.6
inactive: 108.5
Methoxymalonyl-CoA: 74.7
Methylmalonyl-CoA: 66.0
Isobutyryl-CoA: 48.5
Propionyl-CoA: 29.6
Ethylmalonyl-CoA: 27.3
Acetyl-CoA: 26.5
2-Methylbutyryl-CoA: 14.4
Benzoyl-CoA: 14.2
fatty_acid: 11.5
CHC-CoA: 9.1
3-Methylbutyryl-CoA: 8.7
trans-1,2-CPDA: 0.0

ctg545_6: mal

PKS_AT (560..854): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.3
inactive: 101.9
Methoxymalonyl-CoA: 76.4
Methylmalonyl-CoA: 65.2
Isobutyryl-CoA: 42.1
Propionyl-CoA: 33.9
Ethylmalonyl-CoA: 28.4
Acetyl-CoA: 26.0
Benzoyl-CoA: 14.4
2-Methylbutyryl-CoA: 12.8
trans-1,2-CPDA: 9.2
CHC-CoA: 8.6
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

ctg545_7: mal - mal - mal

PKS_AT (569..861): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.9
inactive: 91.1
Methoxymalonyl-CoA: 56.3
Methylmalonyl-CoA: 54.2
Propionyl-CoA: 29.7
Acetyl-CoA: 24.2
2-Methylbutyryl-CoA: 24.2
trans-1,2-CPDA: 23.5
Benzoyl-CoA: 22.6
Isobutyryl-CoA: 20.9
Ethylmalonyl-CoA: 17.9
CHC-CoA: 15.9
fatty_acid: 11.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (1558..1855): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 190.8
inactive: 85.9
Methoxymalonyl-CoA: 66.3
Methylmalonyl-CoA: 60.7
Isobutyryl-CoA: 39.0
Propionyl-CoA: 31.1
Ethylmalonyl-CoA: 26.5
2-Methylbutyryl-CoA: 21.1
Acetyl-CoA: 17.9
fatty_acid: 16.1
trans-1,2-CPDA: 9.0
Benzoyl-CoA: 5.9
CHC-CoA: 5.3
3-Methylbutyryl-CoA: 3.1

PKS_AT (3302..3606): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.4
inactive: 113.1
Methoxymalonyl-CoA: 69.1
Methylmalonyl-CoA: 55.2
Propionyl-CoA: 40.1
Isobutyryl-CoA: 36.2
Ethylmalonyl-CoA: 22.9
2-Methylbutyryl-CoA: 13.1
Acetyl-CoA: 12.3
Benzoyl-CoA: 10.8
fatty_acid: 8.9
trans-1,2-CPDA: 7.2
CHC-CoA: 4.7
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
VqsM	Regulator of quorum-sensing signalling systems

LATD01000625.1 - Region 1 - terpene

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Location: 1 - 1,612 nt. (total: 1,612 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

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Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

ctg585_1: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Similar gene clusters

Analysis type:

Reference	terpene	Similarity score	Type	Compound(s)	Organism
BGC0001181.4		0.81	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0002554.2		0.26	other (other)	carquinostatin A, carquinostatin B	Streptomyces exfoliatus

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0001181.4		0.81	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0002554.2		0.26	other (other)	carquinostatin A, carquinostatin B	Streptomyces exfoliatus

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene		geosmin	C12	C1-C10	OH

Genes with terpene domains:

ctg585_1: T1TS

Domain 1 (14 - 379): Type 1 terpene synthase

Subtype: Geosmin synthase, C terminal domain

Reactions:: germacradienol → geosmin

Detailed Pfam domain annotation

Selected features only

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Terpene

Glossary

No acronyms to display

LATD01000089.1 - Region 1 - lanthipeptide-class-iii

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Location: 4,880 - 27,624 nt. (total: 22,745 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

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Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

ctg637_18: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000551.5	0.82	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000496.5	0.69	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000513.3	0.61	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000501.3	0.61	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000519.4	0.60	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000553.3	0.58	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000518.3	0.55	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0002698.2	0.52	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002700.2	0.51	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0002111.3	0.48	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000551.5	0.82	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000496.5	0.69	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000513.3	0.61	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000501.3	0.61	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000519.4	0.60	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000553.3	0.58	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000518.3	0.55	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0002698.2	0.52	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002700.2	0.51	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0002111.3	0.48	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139

Similar known clusters

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for ctg637_11

ctg637_12

Leader:

MNLLDLQSLEIPKEEAAGDVAT

Core:

GSRASLLLCGDSSLSVVTCN

Core with dehydrations:

GDhaRADhaLLLCysGDDhaDhaLDhaVVDhbCysN

antiSMASH-DB 4.0 matches for ctg637_12

95.0%

NZ_CP077658.1:

Lanthipeptides: KQY30_RS33045_lanthipeptide

1

GSRASLLLCGDSSLSVVTCN

20

SRASLLLCGDSSLSVVTCN

1

ASRASLLLCGDSSLSVVTCN

20

90.5%

NC_018750.1and 88 others:

NC_018750.1 Lanthipeptides: SVEN_RS32110_lanthipeptideNZ_BBNO01000003.1 Lanthipeptides: TU31_RS37940_lanthipeptideNZ_BMSV01000002.1 Lanthipeptides: IE106_RS06150_lanthipeptideNZ_BMTO01000007.1 Lanthipeptides: IE136_RS15615_lanthipeptideNZ_BMTP01000009.1 Lanthipeptides: IE109_RS18470_lanthipeptideNZ_BMTU01000009.1 Lanthipeptides: IE118_RS22890_lanthipeptideNZ_BMUN01000001.1 Lanthipeptides: IE238_RS00740_lanthipeptideNZ_CP007699.2 Lanthipeptides: T261_RS39185_lanthipeptideNZ_CP009754.1 Lanthipeptides: NI25_RS05015_lanthipeptideNZ_CP015866.1 Lanthipeptides: Spa2297_RS27800_lanthipeptideNZ_CP017157.1 Lanthipeptides: SL103_RS15895_lanthipeptideNZ_CP019457.1 Lanthipeptides: BXT88_RS03410_lanthipeptideNZ_CP019724.1 Lanthipeptides: B1H29_RS35355_lanthipeptideNZ_CP019779.1 Lanthipeptides: STRMOE7_RS03775_lanthipeptideNZ_CP020042.1 Lanthipeptides: B4U46_RS32710_lanthipeptideNZ_CP023202.1 Lanthipeptides: SXIN_RS23100_lanthipeptideNZ_CP023691.1 Lanthipeptides: CP981_RS03050_lanthipeptideNZ_CP023692.1 Lanthipeptides: CP980_RS04735_lanthipeptideNZ_CP023700.1 Lanthipeptides: CP969_RS04700_lanthipeptideNZ_CP027299.1 Lanthipeptides: C1N79_RS34970_lanthipeptideNZ_CP028158.1 Lanthipeptides: C6361_RS04660_lanthipeptideNZ_CP028159.1 Lanthipeptides: C6W10_RS01185_lanthipeptideNZ_CP029042.1 Lanthipeptides: DDE74_RS03525_lanthipeptideNZ_CP029195.1 Lanthipeptides: DEJ45_RS04995_lanthipeptideNZ_CP029195.1 Lanthipeptides: DEJ45_RS04995_lanthipeptideNZ_CP029196.1 Lanthipeptides: DEJ44_RS30395_lanthipeptideNZ_CP029196.1 Lanthipeptides: DEJ44_RS30395_lanthipeptideNZ_CP029541.1 Lanthipeptides: DKG71_RS05245_lanthipeptideNZ_CP034279.1 Lanthipeptides: EIZ62_RS28660_lanthipeptideNZ_CP034353.1 Lanthipeptides: D1J63_RS04900_lanthipeptideNZ_CP039123.1 Lanthipeptides: E5N77_RS35250_lanthipeptideNZ_CP043317.1 Lanthipeptides: FYC74_RS09720_lanthipeptideNZ_CP046905.1 Lanthipeptides: GPZ77_RS32930_lanthipeptideNZ_CP047140.1 Lanthipeptides: GLX30_RS11420_lanthipeptideNZ_CP050976.1 Lanthipeptides: HEP86_RS04470_lanthipeptideNZ_CP054920.1 Lanthipeptides: HUT15_RS04615_lanthipeptideNZ_CP060825.1 Lanthipeptides: IAG43_RS32355_lanthipeptideNZ_CP074111.1 Lanthipeptides: KE639_RS31630_lanthipeptideNZ_CP084681.1 Lanthipeptides: KI385_RS00885_lanthipeptideNZ_CP085300.1 Lanthipeptides: LJA35_RS05220_lanthipeptideNZ_CP086217.1 Lanthipeptides: LJ741_RS03435_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS09690_lanthipeptideNZ_CP098437.1 Lanthipeptides: NCG97_RS34740_lanthipeptideNZ_CP099468.1 Lanthipeptides: NFX46_RS16770_lanthipeptideNZ_CP101137.1 Lanthipeptides: M6G08_RS24535_lanthipeptideNZ_CP102332.1 Lanthipeptides: NRO40_RS01140_lanthipeptideNZ_CP102609.1 Lanthipeptides: NUT86_RS03980_lanthipeptideNZ_CP104697.1 Lanthipeptides: N6Q81_RS33560_lanthipeptideNZ_CP114202.1 Lanthipeptides: STRLI_RS35870_lanthipeptideNZ_CP114203.1 Lanthipeptides: STRNI_RS37360_lanthipeptideNZ_CP114205.1 Lanthipeptides: STRTU_RS33380_lanthipeptideNZ_FNHI01000003.1 Lanthipeptides: BLT82_RS06465_lanthipeptideNZ_JACHJE010000006.1 Lanthipeptides: FHS32_RS15850_lanthipeptideNZ_JACHJI010000005.1 Lanthipeptides: FHS37_RS15430_lanthipeptideNZ_JACSCH020000032.1 Lanthipeptides: E0F75_RS38565_lanthipeptideNZ_JACSCH020000032.1 Lanthipeptides: E0F75_RS38565_lanthipeptideNZ_JACSCH020000032.1 Lanthipeptides: E0F75_RS38565_lanthipeptideNZ_JACWAA010000001.1 Lanthipeptides: ICA23_RS00800_lanthipeptideNZ_JADMLH010000003.1 Lanthipeptides: IT780_RS09875_lanthipeptideNZ_JAFEJA010000002.1 Lanthipeptides: JE024_RS34830_lanthipeptideNZ_JAGGOI010000031.1 Lanthipeptides: J7E87_RS22160_lanthipeptideNZ_JAGPXX010000007.1 Lanthipeptides: KBZ10_RS10785_lanthipeptideNZ_JAGPYC010000033.1 Lanthipeptides: KBZ00_RS31440_lanthipeptideNZ_JAHLXF010000022.1 Lanthipeptides: KQY13_RS30555_lanthipeptideNZ_JAIHBQ010000001.1 Lanthipeptides: K4902_RS04515_lanthipeptideNZ_JAJJMU010000026.1 Lanthipeptides: LOC25_RS31275_lanthipeptideNZ_JAJNOJ010000002.1 Lanthipeptides: MBT42_RS06255_lanthipeptideNZ_JAJNOJ010000002.1 Lanthipeptides: MBT42_RS06255_lanthipeptideNZ_JAMGSL010000004.1 Lanthipeptides: M5362_RS09920_lanthipeptideNZ_JAMGSL010000004.1 Lanthipeptides: M5362_RS09920_lanthipeptideNZ_JAPKNL010000004.1 Lanthipeptides: OSI21_RS07750_lanthipeptideNZ_JAPNLM010000003.1 Lanthipeptides: OTB16_RS07305_lanthipeptideNZ_JH993790.1 Lanthipeptides: STRVIR_RS0131905_lanthipeptideNZ_KN039948.1 Lanthipeptides: FM21_RS29525_lanthipeptideNZ_LIPF01000004.1 Lanthipeptides: AMK11_RS16660_lanthipeptideNZ_LIVQ01000005.1 Lanthipeptides: AMK16_RS35205_lanthipeptideNZ_LIVQ01000005.1 Lanthipeptides: AMK16_RS35205_lanthipeptideNZ_LIVV01000002.1 Lanthipeptides: AMK27_RS08700_lanthipeptideNZ_LIVV01000002.1 Lanthipeptides: AMK27_RS08700_lanthipeptideNZ_LIVX01000004.1 Lanthipeptides: AMK29_RS15650_lanthipeptideNZ_LIWB01000010.1 Lanthipeptides: AMK33_RS24360_lanthipeptideNZ_LIYH01000004.1 Lanthipeptides: AMK26_RS17765_lanthipeptideNZ_MPOH02000012.1 Lanthipeptides: BM536_RS17150_lanthipeptideNZ_NBCN01000003.1 Lanthipeptides: BKD26_RS06570_lanthipeptideNZ_NNBP01000011.1 Lanthipeptides: CG747_RS19290_lanthipeptideNZ_NNBP01000011.1 Lanthipeptides: CG747_RS19290_lanthipeptideNZ_RAIF01000032.1 Lanthipeptides: EBH09_RS35480_lanthipeptideNZ_SOPG01000008.1 Lanthipeptides: E0I08_RS17090_lanthipeptide

Lanthipeptides: SVEN_RS32110_lanthipeptide

1

GSRASLLLCGDSSLSVVTCN

20

GSRASLLLCGDSSLSV TCN

2

GSRASLLLCGDSSLSVTTCN

21

90.5%

NZ_BNCA01000002.1and 1 other:

NZ_CP049782.1 Lanthipeptides: G7Z12_RS34445_lanthipeptide

Lanthipeptides: IE314_RS02760_lanthipeptide

1

GSRASLLLCGDSSLSVVTCN

20

GSRASLLLCGDSSLSV TCN

2

GSRASLLLCGDSSLSVSTCN

21

with 70 more sequence matches

Only the first 10 are displayed here.

85.7%

NZ_BBOK01000011.1and 45 others:

NZ_BEWD01000001.1 Lanthipeptides: Sru02f_RS01660_lanthipeptideNZ_BMSL01000016.1 Lanthipeptides: IE215_RS23330_lanthipeptideNZ_BMUC01000023.1 Lanthipeptides: IE172_RS32210_lanthipeptideNZ_BMVE01000003.1 Lanthipeptides: IE248_RS10435_lanthipeptideNZ_BMVL01000005.1 Lanthipeptides: IE257_RS16230_lanthipeptideNZ_BMVQ01000005.1 Lanthipeptides: IE283_RS17035_lanthipeptideNZ_BMWI01000025.1 Lanthipeptides: IE253_RS33945_lanthipeptideNZ_CM002280.1 Lanthipeptides: M877_RS44575_lanthipeptideNZ_CP011664.1 Lanthipeptides: M444_RS30240_lanthipeptideNZ_CP012382.1 Lanthipeptides: SAM23877_RS30085_lanthipeptideNZ_CP012949.1 Lanthipeptides: SAM40697_RS29010_lanthipeptideNZ_CP018047.1 Lanthipeptides: BBN63_RS03065_lanthipeptideNZ_CP020039.1 Lanthipeptides: B4U39_RS34445_lanthipeptideNZ_CP020555.1 Lanthipeptides: B6R96_RS03515_lanthipeptideNZ_CP023701.1 Lanthipeptides: CP968_RS29065_lanthipeptideNZ_CP029189.1 Lanthipeptides: DEJ51_RS31910_lanthipeptideNZ_CP033581.1 Lanthipeptides: EES41_RS31595_lanthipeptideNZ_CP034350.1 Lanthipeptides: D1J60_RS32970_lanthipeptideNZ_CP042324.1 Lanthipeptides: FQ762_RS34495_lanthipeptideNZ_CP043638.1 Lanthipeptides: F1D59_RS34930_lanthipeptideNZ_CP043959.1 Lanthipeptides: F3L20_RS19105_lanthipeptideNZ_CP045547.1 Lanthipeptides: GEV49_RS05730_lanthipeptideNZ_CP048397.1 Lanthipeptides: SSPS47_RS31455_lanthipeptideNZ_CP054939.1 Lanthipeptides: HUT14_RS29815_lanthipeptideNZ_CP094918.1 Lanthipeptides: MTR79_RS16715_lanthipeptideNZ_CP115936.1 Lanthipeptides: PET44_RS28650_lanthipeptideNZ_CP116355.1 Lanthipeptides: KPP03845_RS32700_lanthipeptideNZ_GG657756.1 Lanthipeptides: SSPG_RS05020_lanthipeptideNZ_GG657758.1 Lanthipeptides: SSRG_RS03855_lanthipeptideNZ_JAAIFS010000001.1 Lanthipeptides: GUR47_RS02255_lanthipeptideNZ_JACHEM010000005.1 Lanthipeptides: HNQ79_RS11445_lanthipeptideNZ_JAFLQY010000003.1 Lanthipeptides: J0X20_RS29030_lanthipeptideNZ_KZ195574.1 Lanthipeptides: B9W62_RS05695_lanthipeptideNZ_LIVP01000027.1 Lanthipeptides: AMK15_RS28680_lanthipeptideNZ_LT629768.1 Lanthipeptides: BLU60_RS34110_lanthipeptideNZ_LWLD01000038.1 Lanthipeptides: A6A28_RS28600_lanthipeptideNZ_ML123038.1 Lanthipeptides: EES37_RS30340_lanthipeptideNZ_MQUH01000025.1 Lanthipeptides: BSZ07_RS33280_lanthipeptideNZ_NNBM01000002.1 Lanthipeptides: CG724_RS07855_lanthipeptideNZ_RAII01000001.1 Lanthipeptides: EBH12_RS10360_lanthipeptideNZ_RSEG01000006.1 Lanthipeptides: EIA57_RS12710_lanthipeptideNZ_SOAV01000001.1 Lanthipeptides: EV562_RS04520_lanthipeptideNZ_VIUV01000020.1 Lanthipeptides: FB570_RS34060_lanthipeptideNZ_WHZR01000001.1 Lanthipeptides: STPH1_RS04005_lanthipeptideNZ_WXVT01000001.1 Lanthipeptides: STPH2_RS03995_lanthipeptide

Lanthipeptides: APK71_RS25550_lanthipeptide

1

GSRASLLLCGDSSLSVVTCN

20

GSRASLLLCGDSSLS+ TCN

2

GSRASLLLCGDSSLSITTCN

21

85.7%

NZ_CP048835.1:

Lanthipeptides: C8250_RS00390_lanthipeptide

1

GSRASLLLCGDSSLSVVTCN

20

GSRASLLLCG+SSLSV TCN

2

GSRASLLLCGNSSLSVTTCN

21

85.7%

NZ_QGGR01000008.1:

Lanthipeptides: BC793_RS19230_lanthipeptide

1

GSRASLLLCGDSSLSVVTCN

20

GS+ASLLLCGDSSLSV TCN

2

GSQASLLLCGDSSLSVTTCN

21

85.0%

NZ_CP092183.1:

Lanthipeptides: COUCH_RS09775_lanthipeptide

3

RASLLLCGDSSLSVVTCN

20

RASLLLCGDSSLSV TCN

1

RASLLLCGDSSLSVTTCN

18

83.3%

NZ_JACHJG010000001.1:

Lanthipeptides: FHS38_RS02665_lanthipeptide

1

GSRASLLLCGDSSLSVVTCN

20

GSRASLLLCGDSSLSVVTCN

5

GSRASLLLCGDSSLSVVTCN

24

81.0%

NZ_CP036455.1:

Lanthipeptides: EKD16_RS17975_lanthipeptide

1

GSRASLLLCGDSSLSVVTCN

20

GS ASLLLCGDSSLS+ TCN

2

GSEASLLLCGDSSLSLTTCN

21

81.0%

NZ_FOET01000001.1and 2 others:

NZ_FOSG01000005.1 Lanthipeptides: BM237_RS08435_lanthipeptideNZ_PDKQ02000044.1 Lanthipeptides: BFM75_RS16855_lanthipeptide

Lanthipeptides: BMY40_RS02540_lanthipeptide

1

GSRASLLLCGDSSLSVVTCN

20

GS ASLLLCGDSSLSV TC

2

GSEASLLLCGDSSLSVTTCR

21

80.0%

NC_015434.1and 26 others:

NZ_CP045309.1 Lanthipeptides: GCE86_RS12520_lanthipeptideNZ_CP046104.1 Lanthipeptides: GKC29_RS19975_lanthipeptideNZ_CP059322.1 Lanthipeptides: H1D33_RS20095_lanthipeptideNZ_CP059322.1 Lanthipeptides: H1D33_RS20090_lanthipeptideNZ_FMCR01000005.1 Lanthipeptides: GA0070561_RS23835_lanthipeptideNZ_FMCS01000001.1 Lanthipeptides: GA0070214_RS02345_lanthipeptideNZ_FMCU01000002.1 Lanthipeptides: GA0070216_RS07020_lanthipeptideNZ_FMCU01000002.1 Lanthipeptides: GA0070216_RS07015_lanthipeptideNZ_FMCU01000002.1 Lanthipeptides: GA0070216_RS07010_lanthipeptideNZ_FMDM01000002.1 Lanthipeptides: GA0070213_RS04970_lanthipeptideNZ_HF570108.1 Lanthipeptides: MILUP08_RS22425_lanthipeptideNZ_JADMLH010000003.1 Lanthipeptides: IT780_RS09870_lanthipeptideNZ_JAFEUO010000005.1 Lanthipeptides: JQN84_RS18770_lanthipeptideNZ_JAFEUO010000005.1 Lanthipeptides: JQN84_RS18765_lanthipeptideNZ_JAGFWR010000037.1 Lanthipeptides: JQN83_RS31375_lanthipeptideNZ_JAGFWR010000037.1 Lanthipeptides: JQN83_RS31370_lanthipeptideNZ_JAGPXN010000015.1 Lanthipeptides: KBX06_RS19685_lanthipeptideNZ_JAGPXN010000015.1 Lanthipeptides: KBX06_RS19680_lanthipeptideNZ_JAGPXW010000002.1 Lanthipeptides: KBX71_RS04195_lanthipeptideNZ_LT607409.1 Lanthipeptides: GA0070612_RS21605_lanthipeptideNZ_LT607733.1 Lanthipeptides: GA0070610_RS13855_lanthipeptideNZ_LT607733.1 Lanthipeptides: GA0070610_RS13850_lanthipeptideNZ_LT607752.1 Lanthipeptides: GA0070623_RS04340_lanthipeptideNZ_LT607752.1 Lanthipeptides: GA0070623_RS04335_lanthipeptideNZ_LT607752.1 Lanthipeptides: GA0070623_RS04330_lanthipeptideNZ_RBAK01000011.1 Lanthipeptides: D7223_RS24620_lanthipeptide

Lanthipeptides: VAB18032_RS17930_lanthipeptide

4

ASLLLCGDSSLSVVTCN

20

ASLLLCGDSSLSV TCN

1

ASLLLCGDSSLSVTTCN

17

80.0%

NZ_BMXJ01000002.1and 3 others:

NZ_CP099837.1 Lanthipeptides: NE857_RS18075_lanthipeptideNZ_KI911536.1 Lanthipeptides: B042_RS0117070_lanthipeptideNZ_VWVU01000023.1 Lanthipeptides: FYX01_RS21045_lanthipeptide

Lanthipeptides: IE195_RS04480_lanthipeptide

2

SRASLLLCGDSSLSVVTC

19

S ASLLLCGDSSLSV TC

2

STASLLLCGDSSLSVTTC

19

75.0%

NZ_BBOL01000008.1and 7 others:

NZ_BBOL01000008.1 Lanthipeptides: LPU61_RS25375_lanthipeptideNZ_CP058322.1 Lanthipeptides: HXZ27_RS14120_lanthipeptideNZ_CP058322.1 Lanthipeptides: HXZ27_RS14115_lanthipeptideNZ_FMCT01000009.1 Lanthipeptides: GA0070563_RS21095_lanthipeptideNZ_FMCT01000009.1 Lanthipeptides: GA0070563_RS21090_lanthipeptideNZ_FMCW01000007.1 Lanthipeptides: GA0070558_RS08825_lanthipeptideNZ_FMCW01000007.1 Lanthipeptides: GA0070558_RS08820_lanthipeptide

Lanthipeptides: LPU61_RS25380_lanthipeptide

4

ASLLLCGDSSLSVVTCN

20

ASLLLCGDS LSV TCN

1

ASLLLCGDSGLSVTTCN

17

MIBiG 4.0 matches for ctg637_12

59.1%

BGC0000553.3 (SSGG_RS09925):

Lanthipeptide: SRO15-2212

1

GSRASLLLCGDSSLSVVTCN

20

GS+ SLL+C SSLSVV C

2

GSQVSLLVCEYSSLSVVLCT

21

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.62 out of 30.11

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 25.19 out of 30.11

Confidence: medium

Additional weak hits (2):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.79 out of 29.65

Confidence: weak

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Lanthipeptides

TFBS Finder

Core peptide predictions

ctg637_12 - Class III

Cleavage pHMM score: 27.20

RODEO score: 0

Monoisotopic mass: 1873.0 Da

Molecular weight: 1874.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 1892.1 Da N = 1; 1910.2 Da N = 2; 1928.2 Da N = 3; 1946.2 Da N = 4

TFBS definitions

Regulator	Description
CelR	Cellobiose uptake repressor